Lewis Acid Activation of Fragment-Coupling Reactions of Tertiary Carbon Radicals Promoted by Visible-Light Irradiation of EDA Complexes
The addition of tertiary carbon radicals generated from N-(acyloxy)phthalimide esters to cyclic α,β-unsaturated ketones and lactones is markedly enhanced by the addition of substoichiometric amounts of a Ln(OTf)3. The reaction is accomplished by irradiation with visible light in the absence of a p...
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| Veröffentlicht in: | Organic letters 2021-02, Vol.23 (3), p.1103-1106 |
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| container_title | Organic letters |
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| creator | Pitre, Spencer P Allred, Tyler K Overman, Larry E |
| description | The addition of tertiary carbon radicals generated from N-(acyloxy)phthalimide esters to cyclic α,β-unsaturated ketones and lactones is markedly enhanced by the addition of substoichiometric amounts of a Ln(OTf)3. The reaction is accomplished by irradiation with visible light in the absence of a photosensitizer and is suggested to proceed by excitation of a ternary electron donor–acceptor complex between the NHPI ester, Hantzsch ester, and a Ln(OTf)3. |
| doi_str_mv | 10.1021/acs.orglett.1c00023 |
| format | Article |
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| ispartof | Organic letters, 2021-02, Vol.23 (3), p.1103-1106 |
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| language | eng |
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| source | American Chemical Society Journals |
| title | Lewis Acid Activation of Fragment-Coupling Reactions of Tertiary Carbon Radicals Promoted by Visible-Light Irradiation of EDA Complexes |
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