The role of pleural fluid thiol/disulphide homoeostasis in the differentiation between transudative and exudative pleural effusions
Objective In the present study, we aimed to differentiate between transudative and exudative pleural effusions using thiol sulphide homoeostasis, an oxidative stress marker. Design This was a prospective study. Setting Emergency Department of Ankara City Hospital, between 1 January 2020 and 15 May 2...
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| Veröffentlicht in: | International journal of clinical practice (Esher) 2021-04, Vol.75 (4), p.e14051-n/a |
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| creator | Gormeli Kurt, Nazli Gokhan, Servan Erel, Ozcan Gunes, Celal Kahraman, Ahmet Fatih Ozhasenekler, Ayhan |
| description | Objective
In the present study, we aimed to differentiate between transudative and exudative pleural effusions using thiol sulphide homoeostasis, an oxidative stress marker.
Design
This was a prospective study.
Setting
Emergency Department of Ankara City Hospital, between 1 January 2020 and 15 May 2020.
Subjects
Patients who were diagnosed with pleural effusion and underwent thoracentesis to make a differentiation between transudative and exudative pleural effusions. The patients were divided into two groups as those who have transudative pleural effusion and those who have exudative pleural effusion. These two groups were assessed with respect to demographic features and oxidative stress parameters.
Main Outcome Measures
Oxidative stress parameters (The native thiol (NT), total thiol (TT), and disulphide (D) levels and their ratios to one another were calculated (index 1: D/NT, index 2:D/TT, index 3: NT/TT).
Results
This study enrolled a total of 50 patients with pleural effusion. Twenty patients (40%) were men, and 30 patients (60%) were women. In the transudative pleural effusion group, 14 patients (56%) had decompensated heart failure, 9 patients (36%) had hepatic cirrhosis, and 2 patients (8%) had hypoalbuminemia. In the exudative pleural effusion group, 17 patients (68%) had malignancy, 7 patients (28%) had parapneumonic effusion, and 1 patient (4%) had pulmonary embolism. TT (P |
| doi_str_mv | 10.1111/ijcp.14051 |
| format | Article |
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In the present study, we aimed to differentiate between transudative and exudative pleural effusions using thiol sulphide homoeostasis, an oxidative stress marker.
Design
This was a prospective study.
Setting
Emergency Department of Ankara City Hospital, between 1 January 2020 and 15 May 2020.
Subjects
Patients who were diagnosed with pleural effusion and underwent thoracentesis to make a differentiation between transudative and exudative pleural effusions. The patients were divided into two groups as those who have transudative pleural effusion and those who have exudative pleural effusion. These two groups were assessed with respect to demographic features and oxidative stress parameters.
Main Outcome Measures
Oxidative stress parameters (The native thiol (NT), total thiol (TT), and disulphide (D) levels and their ratios to one another were calculated (index 1: D/NT, index 2:D/TT, index 3: NT/TT).
Results
This study enrolled a total of 50 patients with pleural effusion. Twenty patients (40%) were men, and 30 patients (60%) were women. In the transudative pleural effusion group, 14 patients (56%) had decompensated heart failure, 9 patients (36%) had hepatic cirrhosis, and 2 patients (8%) had hypoalbuminemia. In the exudative pleural effusion group, 17 patients (68%) had malignancy, 7 patients (28%) had parapneumonic effusion, and 1 patient (4%) had pulmonary embolism. TT (P < .001) and NT (P = .001) values were significantly lower in the transudative pleural effusion group compared with the exudative pleural effusion group whereas there was no significant difference between the two groups with respect to D (P = .489), index 1 (P = .07), index 2 (P = .064), and index 3 (P = .063) values.
Conclusion
We believe that a differentiation can be made between transudative and exudative pleural fluids by using thiol sulphide homoeostasis, an oxidative stress marker.</description><identifier>ISSN: 1368-5031</identifier><identifier>EISSN: 1742-1241</identifier><identifier>DOI: 10.1111/ijcp.14051</identifier><identifier>PMID: 33492739</identifier><language>eng</language><publisher>England: Hindawi Limited</publisher><subject>Cirrhosis ; Congestive heart failure ; Diagnosis, Differential ; Disulfides ; Embolism ; Emergency medical care ; Female ; Homeostasis ; Humans ; Liver cirrhosis ; Male ; Malignancy ; Oxidative stress ; Pleural Effusion ; Pleural fluid ; Prospective Studies ; Sulfhydryl Compounds</subject><ispartof>International journal of clinical practice (Esher), 2021-04, Vol.75 (4), p.e14051-n/a</ispartof><rights>2021 John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3161-a2cb1a69c2c0e6d78b755ab64f6b08a73f1c0b04ce4c1c1e767f2b6e11183f0c3</cites><orcidid>0000-0003-4504-1503 ; 0000-0002-1758-3383 ; 0000-0001-8002-0404 ; 0000-0003-1757-9488 ; 0000-0002-2996-3236 ; 0000-0002-2707-4099</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijcp.14051$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijcp.14051$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33492739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gormeli Kurt, Nazli</creatorcontrib><creatorcontrib>Gokhan, Servan</creatorcontrib><creatorcontrib>Erel, Ozcan</creatorcontrib><creatorcontrib>Gunes, Celal</creatorcontrib><creatorcontrib>Kahraman, Ahmet Fatih</creatorcontrib><creatorcontrib>Ozhasenekler, Ayhan</creatorcontrib><title>The role of pleural fluid thiol/disulphide homoeostasis in the differentiation between transudative and exudative pleural effusions</title><title>International journal of clinical practice (Esher)</title><addtitle>Int J Clin Pract</addtitle><description>Objective
In the present study, we aimed to differentiate between transudative and exudative pleural effusions using thiol sulphide homoeostasis, an oxidative stress marker.
Design
This was a prospective study.
Setting
Emergency Department of Ankara City Hospital, between 1 January 2020 and 15 May 2020.
Subjects
Patients who were diagnosed with pleural effusion and underwent thoracentesis to make a differentiation between transudative and exudative pleural effusions. The patients were divided into two groups as those who have transudative pleural effusion and those who have exudative pleural effusion. These two groups were assessed with respect to demographic features and oxidative stress parameters.
Main Outcome Measures
Oxidative stress parameters (The native thiol (NT), total thiol (TT), and disulphide (D) levels and their ratios to one another were calculated (index 1: D/NT, index 2:D/TT, index 3: NT/TT).
Results
This study enrolled a total of 50 patients with pleural effusion. Twenty patients (40%) were men, and 30 patients (60%) were women. In the transudative pleural effusion group, 14 patients (56%) had decompensated heart failure, 9 patients (36%) had hepatic cirrhosis, and 2 patients (8%) had hypoalbuminemia. In the exudative pleural effusion group, 17 patients (68%) had malignancy, 7 patients (28%) had parapneumonic effusion, and 1 patient (4%) had pulmonary embolism. TT (P < .001) and NT (P = .001) values were significantly lower in the transudative pleural effusion group compared with the exudative pleural effusion group whereas there was no significant difference between the two groups with respect to D (P = .489), index 1 (P = .07), index 2 (P = .064), and index 3 (P = .063) values.
Conclusion
We believe that a differentiation can be made between transudative and exudative pleural fluids by using thiol sulphide homoeostasis, an oxidative stress marker.</description><subject>Cirrhosis</subject><subject>Congestive heart failure</subject><subject>Diagnosis, Differential</subject><subject>Disulfides</subject><subject>Embolism</subject><subject>Emergency medical care</subject><subject>Female</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Liver cirrhosis</subject><subject>Male</subject><subject>Malignancy</subject><subject>Oxidative stress</subject><subject>Pleural Effusion</subject><subject>Pleural fluid</subject><subject>Prospective Studies</subject><subject>Sulfhydryl Compounds</subject><issn>1368-5031</issn><issn>1742-1241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kT1vHCEQhlGUKHacNPkBFlKayNLaDCz7UVqn-COylBROjVh20HHiljUscVz7jxvnfC5SZJoZhod3RryEfAZ2CiXO3MbMp1AzCW_IIbQ1r4DX8LbUoukqyQQckA8pbRjjUnbsPTkQou55K_pD8ni7RhqDRxosnT3mqD21PruRLmsX_NnoUvbz2o1I12EbMKRFJ5eomwqAdHTWYsRpcXpxYaIDLveI5S7qKeWxNH8j1dNI8c_-tJ-C1uZU3qSP5J3VPuGnl3xEfl18u11dVTc_Lq9X5zeVEdBApbkZQDe94YZhM7bd0Eqph6a2zcA63QoLhg2sNlgbMIBt01o-NFi-qBOWGXFEvu505xjuMqZFbV0y6L2eMOSkeN2xVgrZy4J--QfdhBynsp3ikvVccA59oU52lIkhpYhWzdFtdXxQwNSzNerZGvXXmgIfv0jmYYvjK7r3ogCwA-6dx4f_SKnr76ufO9EnI6eb3g</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Gormeli Kurt, Nazli</creator><creator>Gokhan, Servan</creator><creator>Erel, Ozcan</creator><creator>Gunes, Celal</creator><creator>Kahraman, Ahmet Fatih</creator><creator>Ozhasenekler, Ayhan</creator><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4504-1503</orcidid><orcidid>https://orcid.org/0000-0002-1758-3383</orcidid><orcidid>https://orcid.org/0000-0001-8002-0404</orcidid><orcidid>https://orcid.org/0000-0003-1757-9488</orcidid><orcidid>https://orcid.org/0000-0002-2996-3236</orcidid><orcidid>https://orcid.org/0000-0002-2707-4099</orcidid></search><sort><creationdate>202104</creationdate><title>The role of pleural fluid thiol/disulphide homoeostasis in the differentiation between transudative and exudative pleural effusions</title><author>Gormeli Kurt, Nazli ; Gokhan, Servan ; Erel, Ozcan ; Gunes, Celal ; Kahraman, Ahmet Fatih ; Ozhasenekler, Ayhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3161-a2cb1a69c2c0e6d78b755ab64f6b08a73f1c0b04ce4c1c1e767f2b6e11183f0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cirrhosis</topic><topic>Congestive heart failure</topic><topic>Diagnosis, Differential</topic><topic>Disulfides</topic><topic>Embolism</topic><topic>Emergency medical care</topic><topic>Female</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Liver cirrhosis</topic><topic>Male</topic><topic>Malignancy</topic><topic>Oxidative stress</topic><topic>Pleural Effusion</topic><topic>Pleural fluid</topic><topic>Prospective Studies</topic><topic>Sulfhydryl Compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gormeli Kurt, Nazli</creatorcontrib><creatorcontrib>Gokhan, Servan</creatorcontrib><creatorcontrib>Erel, Ozcan</creatorcontrib><creatorcontrib>Gunes, Celal</creatorcontrib><creatorcontrib>Kahraman, Ahmet Fatih</creatorcontrib><creatorcontrib>Ozhasenekler, Ayhan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical practice (Esher)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gormeli Kurt, Nazli</au><au>Gokhan, Servan</au><au>Erel, Ozcan</au><au>Gunes, Celal</au><au>Kahraman, Ahmet Fatih</au><au>Ozhasenekler, Ayhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of pleural fluid thiol/disulphide homoeostasis in the differentiation between transudative and exudative pleural effusions</atitle><jtitle>International journal of clinical practice (Esher)</jtitle><addtitle>Int J Clin Pract</addtitle><date>2021-04</date><risdate>2021</risdate><volume>75</volume><issue>4</issue><spage>e14051</spage><epage>n/a</epage><pages>e14051-n/a</pages><issn>1368-5031</issn><eissn>1742-1241</eissn><abstract>Objective
In the present study, we aimed to differentiate between transudative and exudative pleural effusions using thiol sulphide homoeostasis, an oxidative stress marker.
Design
This was a prospective study.
Setting
Emergency Department of Ankara City Hospital, between 1 January 2020 and 15 May 2020.
Subjects
Patients who were diagnosed with pleural effusion and underwent thoracentesis to make a differentiation between transudative and exudative pleural effusions. The patients were divided into two groups as those who have transudative pleural effusion and those who have exudative pleural effusion. These two groups were assessed with respect to demographic features and oxidative stress parameters.
Main Outcome Measures
Oxidative stress parameters (The native thiol (NT), total thiol (TT), and disulphide (D) levels and their ratios to one another were calculated (index 1: D/NT, index 2:D/TT, index 3: NT/TT).
Results
This study enrolled a total of 50 patients with pleural effusion. Twenty patients (40%) were men, and 30 patients (60%) were women. In the transudative pleural effusion group, 14 patients (56%) had decompensated heart failure, 9 patients (36%) had hepatic cirrhosis, and 2 patients (8%) had hypoalbuminemia. In the exudative pleural effusion group, 17 patients (68%) had malignancy, 7 patients (28%) had parapneumonic effusion, and 1 patient (4%) had pulmonary embolism. TT (P < .001) and NT (P = .001) values were significantly lower in the transudative pleural effusion group compared with the exudative pleural effusion group whereas there was no significant difference between the two groups with respect to D (P = .489), index 1 (P = .07), index 2 (P = .064), and index 3 (P = .063) values.
Conclusion
We believe that a differentiation can be made between transudative and exudative pleural fluids by using thiol sulphide homoeostasis, an oxidative stress marker.</abstract><cop>England</cop><pub>Hindawi Limited</pub><pmid>33492739</pmid><doi>10.1111/ijcp.14051</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-4504-1503</orcidid><orcidid>https://orcid.org/0000-0002-1758-3383</orcidid><orcidid>https://orcid.org/0000-0001-8002-0404</orcidid><orcidid>https://orcid.org/0000-0003-1757-9488</orcidid><orcidid>https://orcid.org/0000-0002-2996-3236</orcidid><orcidid>https://orcid.org/0000-0002-2707-4099</orcidid></addata></record> |
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| issn | 1368-5031 1742-1241 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Cirrhosis Congestive heart failure Diagnosis, Differential Disulfides Embolism Emergency medical care Female Homeostasis Humans Liver cirrhosis Male Malignancy Oxidative stress Pleural Effusion Pleural fluid Prospective Studies Sulfhydryl Compounds |
| title | The role of pleural fluid thiol/disulphide homoeostasis in the differentiation between transudative and exudative pleural effusions |
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