Hydrogen as a Potential Therapeutic in Obesity: Targeting the Brain

Clinical applications of molecular hydrogen (H2) seem to favorably affect obesity-related metabolic biomarkers in peripheral tissues, yet whether H2 directly tackles obesity pathways in the brain remains elusive. I summarize here several molecular targets in the hypothalamus and beyond that could be...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2021-04, Vol.32 (4), p.191-193
1. Verfasser:	Ostojic, Sergej M.
Format:	Artikel
Sprache:	eng
Schlagworte:	brain-derived neurotropic factor Humans hydrogen Hydrogen - pharmacology Hydrogen - therapeutic use hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism obesity Obesity - drug therapy Obesity - physiopathology pro-opiomelanocortin synaptophysin
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Zusammenfassung:	Clinical applications of molecular hydrogen (H2) seem to favorably affect obesity-related metabolic biomarkers in peripheral tissues, yet whether H2 directly tackles obesity pathways in the brain remains elusive. I summarize here several molecular targets in the hypothalamus and beyond that could be altered by H2 gas in obesity.
ISSN:	1043-2760 1879-3061
DOI:	10.1016/j.tem.2021.01.002