Coronary artery disease and heart failure in patients with idiopathic pulmonary fibrosis
The aim of this study was to investigate the prevalence and prognostic value of coronary artery disease (CAD) and heart failure (HF) in patients with idiopathic pulmonary fibrosis (IPF). Thirteen hundred and fifty-eight patients with interstitial lung disease [851 (62%) males, mean age: 68 ± 10 year...
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| Veröffentlicht in: | Heart and vessels 2021-08, Vol.36 (8), p.1151-1158 |
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| creator | Kato, Shingo Kitamura, Hideya Hayakawa, Keigo Fukui, Kazuki Tabata, Erina Otoshi, Ryota Iwasawa, Tae Utsunomiya, Daisuke Kimura, Kazuo Tamura, Kouichi Ogura, Takashi |
| description | The aim of this study was to investigate the prevalence and prognostic value of coronary artery disease (CAD) and heart failure (HF) in patients with idiopathic pulmonary fibrosis (IPF). Thirteen hundred and fifty-eight patients with interstitial lung disease [851 (62%) males, mean age: 68 ± 10 years] were retrospectively analyzed. CAD was defined as (1) the presence of a clinical diagnosis of angina pectoris, (2) clinical diagnosis of a myocardial infarction, and (3) coronary angiography showing ≥ 1 vessel with a stenosis of > 75%. The definition of HF was made according to the modified Framingham criteria. Compared to the non-IPF group (
n
= 790), the IPF group (
n
= 568) had a significantly higher prevalence of CAD (9.3% vs. 4.4%,
p
|
| doi_str_mv | 10.1007/s00380-021-01787-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2480747622</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2548930687</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-67e063f2b21ca7060666dc3cb9e12b6870ec2db9f0e6cdc384fbdec7ddb23d013</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMoun78AQ8S8OKlOknapD3K4hcIXhS8hTSZulm67Zq0iP_eaFcFD54GZp55552XkGMG5wxAXUQAUUIGnGXAVKkytkVmTLIi44US22QGFYOsFFztkf0YlwCsqFi1S_aEyEtZFPmMPM_70HcmvFMTBkzF-YgmIjWdowtMTdoY344Bqe_o2gweuyHSNz8sqHe-T52Ft3Q9tqtJpvF16KOPh2SnMW3Eo009IE_XV4_z2-z-4eZufnmfWVFVQyYVghQNrzmzRoEEKaWzwtYVMl7LUgFa7uqqAZQ2Dcq8qR1a5VzNhQMmDsjZpLsO_euIcdArHy22remwH6PmeQkqV5LzhJ7-QZf9GLrkTvMiLysB6V6i-ETZ9EcM2Oh18Kv0mmagP3PXU-465a6_ctefLk420mO9Qvez8h10AsQExDTqXjD83v5H9gMVf47R</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2548930687</pqid></control><display><type>article</type><title>Coronary artery disease and heart failure in patients with idiopathic pulmonary fibrosis</title><source>SpringerLink Journals</source><creator>Kato, Shingo ; Kitamura, Hideya ; Hayakawa, Keigo ; Fukui, Kazuki ; Tabata, Erina ; Otoshi, Ryota ; Iwasawa, Tae ; Utsunomiya, Daisuke ; Kimura, Kazuo ; Tamura, Kouichi ; Ogura, Takashi</creator><creatorcontrib>Kato, Shingo ; Kitamura, Hideya ; Hayakawa, Keigo ; Fukui, Kazuki ; Tabata, Erina ; Otoshi, Ryota ; Iwasawa, Tae ; Utsunomiya, Daisuke ; Kimura, Kazuo ; Tamura, Kouichi ; Ogura, Takashi</creatorcontrib><description>The aim of this study was to investigate the prevalence and prognostic value of coronary artery disease (CAD) and heart failure (HF) in patients with idiopathic pulmonary fibrosis (IPF). Thirteen hundred and fifty-eight patients with interstitial lung disease [851 (62%) males, mean age: 68 ± 10 years] were retrospectively analyzed. CAD was defined as (1) the presence of a clinical diagnosis of angina pectoris, (2) clinical diagnosis of a myocardial infarction, and (3) coronary angiography showing ≥ 1 vessel with a stenosis of > 75%. The definition of HF was made according to the modified Framingham criteria. Compared to the non-IPF group (
n
= 790), the IPF group (
n
= 568) had a significantly higher prevalence of CAD (9.3% vs. 4.4%,
p
< 0.001) and HF (8.2% vs. 3.7%,
p
< 0.001). During a median follow-up of 1.6 years, 152 deaths were identified. The patients with HF had a significantly worse prognosis than those without HF both in the non-IPF group and IPF group (both
p
< 0.05). However, the prognosis did not significantly differ between the patients with CAD and those without CAD both in the non-IPF group and IPF group. The presence of HF was an independent predictor of death in the IPF [hazard ratio (HR) 3.67, 95% confidence interval (CI) 1.57–8.56,
p
= 0.0025] and non-IPF (HR 5.07, 95% CI 1.44–17.86,
p
= 0.011) patients. The prevalence of CAD and HF was significantly higher in IPF than non-IPF patients. In addition, the presence of HF was a significant prognostic factor for both IPF and non-IPF patients. These results indicated that the importance of HF as a comorbidity for patients with ILD.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-021-01787-1</identifier><identifier>PMID: 33486554</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Angina ; Angina pectoris ; Angiography ; Biomedical Engineering and Bioengineering ; Blood vessels ; Cardiac Surgery ; Cardiology ; Cardiovascular disease ; Confidence intervals ; Congestive heart failure ; Coronary artery ; Coronary artery disease ; Coronary vessels ; Diagnosis ; Fibrosis ; Heart failure ; Lung diseases ; Medicine ; Medicine & Public Health ; Myocardial infarction ; Original Article ; Prognosis ; Pulmonary fibrosis ; Stenosis ; Vascular Surgery</subject><ispartof>Heart and vessels, 2021-08, Vol.36 (8), p.1151-1158</ispartof><rights>Springer Japan KK, part of Springer Nature 2021</rights><rights>Springer Japan KK, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-67e063f2b21ca7060666dc3cb9e12b6870ec2db9f0e6cdc384fbdec7ddb23d013</citedby><cites>FETCH-LOGICAL-c399t-67e063f2b21ca7060666dc3cb9e12b6870ec2db9f0e6cdc384fbdec7ddb23d013</cites><orcidid>0000-0002-7545-0669</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-021-01787-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-021-01787-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33486554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kato, Shingo</creatorcontrib><creatorcontrib>Kitamura, Hideya</creatorcontrib><creatorcontrib>Hayakawa, Keigo</creatorcontrib><creatorcontrib>Fukui, Kazuki</creatorcontrib><creatorcontrib>Tabata, Erina</creatorcontrib><creatorcontrib>Otoshi, Ryota</creatorcontrib><creatorcontrib>Iwasawa, Tae</creatorcontrib><creatorcontrib>Utsunomiya, Daisuke</creatorcontrib><creatorcontrib>Kimura, Kazuo</creatorcontrib><creatorcontrib>Tamura, Kouichi</creatorcontrib><creatorcontrib>Ogura, Takashi</creatorcontrib><title>Coronary artery disease and heart failure in patients with idiopathic pulmonary fibrosis</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>The aim of this study was to investigate the prevalence and prognostic value of coronary artery disease (CAD) and heart failure (HF) in patients with idiopathic pulmonary fibrosis (IPF). Thirteen hundred and fifty-eight patients with interstitial lung disease [851 (62%) males, mean age: 68 ± 10 years] were retrospectively analyzed. CAD was defined as (1) the presence of a clinical diagnosis of angina pectoris, (2) clinical diagnosis of a myocardial infarction, and (3) coronary angiography showing ≥ 1 vessel with a stenosis of > 75%. The definition of HF was made according to the modified Framingham criteria. Compared to the non-IPF group (
n
= 790), the IPF group (
n
= 568) had a significantly higher prevalence of CAD (9.3% vs. 4.4%,
p
< 0.001) and HF (8.2% vs. 3.7%,
p
< 0.001). During a median follow-up of 1.6 years, 152 deaths were identified. The patients with HF had a significantly worse prognosis than those without HF both in the non-IPF group and IPF group (both
p
< 0.05). However, the prognosis did not significantly differ between the patients with CAD and those without CAD both in the non-IPF group and IPF group. The presence of HF was an independent predictor of death in the IPF [hazard ratio (HR) 3.67, 95% confidence interval (CI) 1.57–8.56,
p
= 0.0025] and non-IPF (HR 5.07, 95% CI 1.44–17.86,
p
= 0.011) patients. The prevalence of CAD and HF was significantly higher in IPF than non-IPF patients. In addition, the presence of HF was a significant prognostic factor for both IPF and non-IPF patients. These results indicated that the importance of HF as a comorbidity for patients with ILD.</description><subject>Angina</subject><subject>Angina pectoris</subject><subject>Angiography</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Blood vessels</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Confidence intervals</subject><subject>Congestive heart failure</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary vessels</subject><subject>Diagnosis</subject><subject>Fibrosis</subject><subject>Heart failure</subject><subject>Lung diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Myocardial infarction</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Pulmonary fibrosis</subject><subject>Stenosis</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMoun78AQ8S8OKlOknapD3K4hcIXhS8hTSZulm67Zq0iP_eaFcFD54GZp55552XkGMG5wxAXUQAUUIGnGXAVKkytkVmTLIi44US22QGFYOsFFztkf0YlwCsqFi1S_aEyEtZFPmMPM_70HcmvFMTBkzF-YgmIjWdowtMTdoY344Bqe_o2gweuyHSNz8sqHe-T52Ft3Q9tqtJpvF16KOPh2SnMW3Eo009IE_XV4_z2-z-4eZufnmfWVFVQyYVghQNrzmzRoEEKaWzwtYVMl7LUgFa7uqqAZQ2Dcq8qR1a5VzNhQMmDsjZpLsO_euIcdArHy22remwH6PmeQkqV5LzhJ7-QZf9GLrkTvMiLysB6V6i-ETZ9EcM2Oh18Kv0mmagP3PXU-465a6_ctefLk420mO9Qvez8h10AsQExDTqXjD83v5H9gMVf47R</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Kato, Shingo</creator><creator>Kitamura, Hideya</creator><creator>Hayakawa, Keigo</creator><creator>Fukui, Kazuki</creator><creator>Tabata, Erina</creator><creator>Otoshi, Ryota</creator><creator>Iwasawa, Tae</creator><creator>Utsunomiya, Daisuke</creator><creator>Kimura, Kazuo</creator><creator>Tamura, Kouichi</creator><creator>Ogura, Takashi</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7545-0669</orcidid></search><sort><creationdate>20210801</creationdate><title>Coronary artery disease and heart failure in patients with idiopathic pulmonary fibrosis</title><author>Kato, Shingo ; Kitamura, Hideya ; Hayakawa, Keigo ; Fukui, Kazuki ; Tabata, Erina ; Otoshi, Ryota ; Iwasawa, Tae ; Utsunomiya, Daisuke ; Kimura, Kazuo ; Tamura, Kouichi ; Ogura, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-67e063f2b21ca7060666dc3cb9e12b6870ec2db9f0e6cdc384fbdec7ddb23d013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Angina</topic><topic>Angina pectoris</topic><topic>Angiography</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Blood vessels</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Confidence intervals</topic><topic>Congestive heart failure</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary vessels</topic><topic>Diagnosis</topic><topic>Fibrosis</topic><topic>Heart failure</topic><topic>Lung diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Myocardial infarction</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Pulmonary fibrosis</topic><topic>Stenosis</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kato, Shingo</creatorcontrib><creatorcontrib>Kitamura, Hideya</creatorcontrib><creatorcontrib>Hayakawa, Keigo</creatorcontrib><creatorcontrib>Fukui, Kazuki</creatorcontrib><creatorcontrib>Tabata, Erina</creatorcontrib><creatorcontrib>Otoshi, Ryota</creatorcontrib><creatorcontrib>Iwasawa, Tae</creatorcontrib><creatorcontrib>Utsunomiya, Daisuke</creatorcontrib><creatorcontrib>Kimura, Kazuo</creatorcontrib><creatorcontrib>Tamura, Kouichi</creatorcontrib><creatorcontrib>Ogura, Takashi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kato, Shingo</au><au>Kitamura, Hideya</au><au>Hayakawa, Keigo</au><au>Fukui, Kazuki</au><au>Tabata, Erina</au><au>Otoshi, Ryota</au><au>Iwasawa, Tae</au><au>Utsunomiya, Daisuke</au><au>Kimura, Kazuo</au><au>Tamura, Kouichi</au><au>Ogura, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary artery disease and heart failure in patients with idiopathic pulmonary fibrosis</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>36</volume><issue>8</issue><spage>1151</spage><epage>1158</epage><pages>1151-1158</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><abstract>The aim of this study was to investigate the prevalence and prognostic value of coronary artery disease (CAD) and heart failure (HF) in patients with idiopathic pulmonary fibrosis (IPF). Thirteen hundred and fifty-eight patients with interstitial lung disease [851 (62%) males, mean age: 68 ± 10 years] were retrospectively analyzed. CAD was defined as (1) the presence of a clinical diagnosis of angina pectoris, (2) clinical diagnosis of a myocardial infarction, and (3) coronary angiography showing ≥ 1 vessel with a stenosis of > 75%. The definition of HF was made according to the modified Framingham criteria. Compared to the non-IPF group (
n
= 790), the IPF group (
n
= 568) had a significantly higher prevalence of CAD (9.3% vs. 4.4%,
p
< 0.001) and HF (8.2% vs. 3.7%,
p
< 0.001). During a median follow-up of 1.6 years, 152 deaths were identified. The patients with HF had a significantly worse prognosis than those without HF both in the non-IPF group and IPF group (both
p
< 0.05). However, the prognosis did not significantly differ between the patients with CAD and those without CAD both in the non-IPF group and IPF group. The presence of HF was an independent predictor of death in the IPF [hazard ratio (HR) 3.67, 95% confidence interval (CI) 1.57–8.56,
p
= 0.0025] and non-IPF (HR 5.07, 95% CI 1.44–17.86,
p
= 0.011) patients. The prevalence of CAD and HF was significantly higher in IPF than non-IPF patients. In addition, the presence of HF was a significant prognostic factor for both IPF and non-IPF patients. These results indicated that the importance of HF as a comorbidity for patients with ILD.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>33486554</pmid><doi>10.1007/s00380-021-01787-1</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7545-0669</orcidid></addata></record> |
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| subjects | Angina Angina pectoris Angiography Biomedical Engineering and Bioengineering Blood vessels Cardiac Surgery Cardiology Cardiovascular disease Confidence intervals Congestive heart failure Coronary artery Coronary artery disease Coronary vessels Diagnosis Fibrosis Heart failure Lung diseases Medicine Medicine & Public Health Myocardial infarction Original Article Prognosis Pulmonary fibrosis Stenosis Vascular Surgery |
| title | Coronary artery disease and heart failure in patients with idiopathic pulmonary fibrosis |
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