The systemic inflammation response index predicts the survival of patients with clinical T1‐2N0 oral squamous cell carcinoma
Objective The systemic inflammation response index (SIRI) is an independent prognostic factor for many malignant tumors. However, the value of this factor in patients with clinical T1‐2N0 (cT1‐2N0) oral squamous cell carcinoma (OSCC) is still unclear. Methods We calculated SIRI of 235 cT1‐2N0 OSCC p...
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| Veröffentlicht in: | Oral diseases 2022-04, Vol.28 (3), p.600-610 |
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| creator | Song, Fan Cai, Hongshi Liao, Yan Huang, Shuojin Jiang, Yaoqi Liang, Jianfeng Xie, Nan Hou, Jinsong |
| description | Objective
The systemic inflammation response index (SIRI) is an independent prognostic factor for many malignant tumors. However, the value of this factor in patients with clinical T1‐2N0 (cT1‐2N0) oral squamous cell carcinoma (OSCC) is still unclear.
Methods
We calculated SIRI of 235 cT1‐2N0 OSCC patients from 2013 to 2017. Multivariate cox regression analysis was applied to verify the prognostic significance of SIRI. Kaplan–Meier curves were plotted to analyze the overall survival (OS) and disease‐specific survival (DSS) for cT1‐2N0 OSCC patients.
Results
According to the optimal cutoff point of SIRI, we divided cT1‐2N0 OSCC patients into high SIRI group (SIRI ≥ 1.3) and low SIRI group (SIRI |
| doi_str_mv | 10.1111/odi.13782 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2480735542</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2636215386</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-c38917653c3bfaef6210b745b82a76bb0b012f786a293e2c388069ff3de1823</originalsourceid><addsrcrecordid>eNp1kc9OHSEUxkljU_-0i75AQ-KmLq4CZ2C4S2Nta2LqonfRHWGYQ8TMDCPMaO-m8RH6jD6J3F7bhUlZAIfz4ztf8hHynrNjXtZJbMMxh1qLV2SPK8YXTAu5U-4gq4UU8GOX7Od8wxivlyDekF2ASisNsEd-ra6R5nWesA-OhsF3tu_tFOJAE-YxDhnLa4s_6ZiwDW7KdNr8mNNduLMdjZ6OBcehNO7DdE1dF4bgSmfFHx9-i2-MxlSqfDvbPs6ZOuw66mxyYYi9fUtee9tlfPd8HpDvn89XZ18Xl1dfLs5OLxcOJIiy6yWvlQQHjbfoleCsqSvZaGFr1TSsYVz4WisrloCi4JqppffQItcCDsjHreqY4u2MeTJ9yBsjdsDiyYhKsxqkrDbo4Qv0Js5pKN6MUFDmStCqUEdbyqWYc0JvxhR6m9aGM7OJxJRIzJ9ICvvhWXFuemz_kX8zKMDJFrgPHa7_r2SuPl1sJZ8A8ySW7g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2636215386</pqid></control><display><type>article</type><title>The systemic inflammation response index predicts the survival of patients with clinical T1‐2N0 oral squamous cell carcinoma</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Song, Fan ; Cai, Hongshi ; Liao, Yan ; Huang, Shuojin ; Jiang, Yaoqi ; Liang, Jianfeng ; Xie, Nan ; Hou, Jinsong</creator><creatorcontrib>Song, Fan ; Cai, Hongshi ; Liao, Yan ; Huang, Shuojin ; Jiang, Yaoqi ; Liang, Jianfeng ; Xie, Nan ; Hou, Jinsong</creatorcontrib><description>Objective
The systemic inflammation response index (SIRI) is an independent prognostic factor for many malignant tumors. However, the value of this factor in patients with clinical T1‐2N0 (cT1‐2N0) oral squamous cell carcinoma (OSCC) is still unclear.
Methods
We calculated SIRI of 235 cT1‐2N0 OSCC patients from 2013 to 2017. Multivariate cox regression analysis was applied to verify the prognostic significance of SIRI. Kaplan–Meier curves were plotted to analyze the overall survival (OS) and disease‐specific survival (DSS) for cT1‐2N0 OSCC patients.
Results
According to the optimal cutoff point of SIRI, we divided cT1‐2N0 OSCC patients into high SIRI group (SIRI ≥ 1.3) and low SIRI group (SIRI < 1.3). SIRI was an independent prognostic indicator for OS (HR = 2.87; 95% CI = 1.35–6.10; p = .006) and DSS (HR = 2.17; 95% CI = 1.10–4.27; p = .025). High SIRI had a significantly poorer OS (p = .001) and DSS (p = .007) in survival analysis than the low SIRI. Moreover, the prognostic value of SIRI was significantly stronger than neutrophil‐to‐lymphocyte ratio (NLR) and monocyte‐to‐lymphocyte ratio (MLR).
Conclusions
Preoperative SIRI can be regarded as a meaningful indicator for poor survival of cT1‐2N0 OSCC patients, and it is a promising tool to formulate the best individualized treatment for high‐risk patients.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.13782</identifier><identifier>PMID: 33486833</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Carcinoma, Squamous Cell ; Head and Neck Neoplasms ; Humans ; Inflammation ; Inflammation - pathology ; Leukocytes (neutrophilic) ; Lymphocytes ; Monocytes ; monocyte‐to‐lymphocyte ratio ; Mouth Neoplasms ; neutrophil‐to‐lymphocyte ratio ; Oral cancer ; Oral carcinoma ; Oral squamous cell carcinoma ; Patients ; Prognosis ; Retrospective Studies ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck ; survival ; Survival analysis ; systemic inflammation response index ; Tumors</subject><ispartof>Oral diseases, 2022-04, Vol.28 (3), p.600-610</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><rights>2022 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-c38917653c3bfaef6210b745b82a76bb0b012f786a293e2c388069ff3de1823</citedby><cites>FETCH-LOGICAL-c3532-c38917653c3bfaef6210b745b82a76bb0b012f786a293e2c388069ff3de1823</cites><orcidid>0000-0001-5330-9528</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.13782$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.13782$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33486833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Fan</creatorcontrib><creatorcontrib>Cai, Hongshi</creatorcontrib><creatorcontrib>Liao, Yan</creatorcontrib><creatorcontrib>Huang, Shuojin</creatorcontrib><creatorcontrib>Jiang, Yaoqi</creatorcontrib><creatorcontrib>Liang, Jianfeng</creatorcontrib><creatorcontrib>Xie, Nan</creatorcontrib><creatorcontrib>Hou, Jinsong</creatorcontrib><title>The systemic inflammation response index predicts the survival of patients with clinical T1‐2N0 oral squamous cell carcinoma</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objective
The systemic inflammation response index (SIRI) is an independent prognostic factor for many malignant tumors. However, the value of this factor in patients with clinical T1‐2N0 (cT1‐2N0) oral squamous cell carcinoma (OSCC) is still unclear.
Methods
We calculated SIRI of 235 cT1‐2N0 OSCC patients from 2013 to 2017. Multivariate cox regression analysis was applied to verify the prognostic significance of SIRI. Kaplan–Meier curves were plotted to analyze the overall survival (OS) and disease‐specific survival (DSS) for cT1‐2N0 OSCC patients.
Results
According to the optimal cutoff point of SIRI, we divided cT1‐2N0 OSCC patients into high SIRI group (SIRI ≥ 1.3) and low SIRI group (SIRI < 1.3). SIRI was an independent prognostic indicator for OS (HR = 2.87; 95% CI = 1.35–6.10; p = .006) and DSS (HR = 2.17; 95% CI = 1.10–4.27; p = .025). High SIRI had a significantly poorer OS (p = .001) and DSS (p = .007) in survival analysis than the low SIRI. Moreover, the prognostic value of SIRI was significantly stronger than neutrophil‐to‐lymphocyte ratio (NLR) and monocyte‐to‐lymphocyte ratio (MLR).
Conclusions
Preoperative SIRI can be regarded as a meaningful indicator for poor survival of cT1‐2N0 OSCC patients, and it is a promising tool to formulate the best individualized treatment for high‐risk patients.</description><subject>Carcinoma, Squamous Cell</subject><subject>Head and Neck Neoplasms</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - pathology</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes</subject><subject>Monocytes</subject><subject>monocyte‐to‐lymphocyte ratio</subject><subject>Mouth Neoplasms</subject><subject>neutrophil‐to‐lymphocyte ratio</subject><subject>Oral cancer</subject><subject>Oral carcinoma</subject><subject>Oral squamous cell carcinoma</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Squamous cell carcinoma</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>survival</subject><subject>Survival analysis</subject><subject>systemic inflammation response index</subject><subject>Tumors</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9OHSEUxkljU_-0i75AQ-KmLq4CZ2C4S2Nta2LqonfRHWGYQ8TMDCPMaO-m8RH6jD6J3F7bhUlZAIfz4ztf8hHynrNjXtZJbMMxh1qLV2SPK8YXTAu5U-4gq4UU8GOX7Od8wxivlyDekF2ASisNsEd-ra6R5nWesA-OhsF3tu_tFOJAE-YxDhnLa4s_6ZiwDW7KdNr8mNNduLMdjZ6OBcehNO7DdE1dF4bgSmfFHx9-i2-MxlSqfDvbPs6ZOuw66mxyYYi9fUtee9tlfPd8HpDvn89XZ18Xl1dfLs5OLxcOJIiy6yWvlQQHjbfoleCsqSvZaGFr1TSsYVz4WisrloCi4JqppffQItcCDsjHreqY4u2MeTJ9yBsjdsDiyYhKsxqkrDbo4Qv0Js5pKN6MUFDmStCqUEdbyqWYc0JvxhR6m9aGM7OJxJRIzJ9ICvvhWXFuemz_kX8zKMDJFrgPHa7_r2SuPl1sJZ8A8ySW7g</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Song, Fan</creator><creator>Cai, Hongshi</creator><creator>Liao, Yan</creator><creator>Huang, Shuojin</creator><creator>Jiang, Yaoqi</creator><creator>Liang, Jianfeng</creator><creator>Xie, Nan</creator><creator>Hou, Jinsong</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5330-9528</orcidid></search><sort><creationdate>202204</creationdate><title>The systemic inflammation response index predicts the survival of patients with clinical T1‐2N0 oral squamous cell carcinoma</title><author>Song, Fan ; Cai, Hongshi ; Liao, Yan ; Huang, Shuojin ; Jiang, Yaoqi ; Liang, Jianfeng ; Xie, Nan ; Hou, Jinsong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-c38917653c3bfaef6210b745b82a76bb0b012f786a293e2c388069ff3de1823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Carcinoma, Squamous Cell</topic><topic>Head and Neck Neoplasms</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - pathology</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocytes</topic><topic>Monocytes</topic><topic>monocyte‐to‐lymphocyte ratio</topic><topic>Mouth Neoplasms</topic><topic>neutrophil‐to‐lymphocyte ratio</topic><topic>Oral cancer</topic><topic>Oral carcinoma</topic><topic>Oral squamous cell carcinoma</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Squamous cell carcinoma</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>survival</topic><topic>Survival analysis</topic><topic>systemic inflammation response index</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Fan</creatorcontrib><creatorcontrib>Cai, Hongshi</creatorcontrib><creatorcontrib>Liao, Yan</creatorcontrib><creatorcontrib>Huang, Shuojin</creatorcontrib><creatorcontrib>Jiang, Yaoqi</creatorcontrib><creatorcontrib>Liang, Jianfeng</creatorcontrib><creatorcontrib>Xie, Nan</creatorcontrib><creatorcontrib>Hou, Jinsong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Fan</au><au>Cai, Hongshi</au><au>Liao, Yan</au><au>Huang, Shuojin</au><au>Jiang, Yaoqi</au><au>Liang, Jianfeng</au><au>Xie, Nan</au><au>Hou, Jinsong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The systemic inflammation response index predicts the survival of patients with clinical T1‐2N0 oral squamous cell carcinoma</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2022-04</date><risdate>2022</risdate><volume>28</volume><issue>3</issue><spage>600</spage><epage>610</epage><pages>600-610</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Objective
The systemic inflammation response index (SIRI) is an independent prognostic factor for many malignant tumors. However, the value of this factor in patients with clinical T1‐2N0 (cT1‐2N0) oral squamous cell carcinoma (OSCC) is still unclear.
Methods
We calculated SIRI of 235 cT1‐2N0 OSCC patients from 2013 to 2017. Multivariate cox regression analysis was applied to verify the prognostic significance of SIRI. Kaplan–Meier curves were plotted to analyze the overall survival (OS) and disease‐specific survival (DSS) for cT1‐2N0 OSCC patients.
Results
According to the optimal cutoff point of SIRI, we divided cT1‐2N0 OSCC patients into high SIRI group (SIRI ≥ 1.3) and low SIRI group (SIRI < 1.3). SIRI was an independent prognostic indicator for OS (HR = 2.87; 95% CI = 1.35–6.10; p = .006) and DSS (HR = 2.17; 95% CI = 1.10–4.27; p = .025). High SIRI had a significantly poorer OS (p = .001) and DSS (p = .007) in survival analysis than the low SIRI. Moreover, the prognostic value of SIRI was significantly stronger than neutrophil‐to‐lymphocyte ratio (NLR) and monocyte‐to‐lymphocyte ratio (MLR).
Conclusions
Preoperative SIRI can be regarded as a meaningful indicator for poor survival of cT1‐2N0 OSCC patients, and it is a promising tool to formulate the best individualized treatment for high‐risk patients.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33486833</pmid><doi>10.1111/odi.13782</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5330-9528</orcidid></addata></record> |
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| ispartof | Oral diseases, 2022-04, Vol.28 (3), p.600-610 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Carcinoma, Squamous Cell Head and Neck Neoplasms Humans Inflammation Inflammation - pathology Leukocytes (neutrophilic) Lymphocytes Monocytes monocyte‐to‐lymphocyte ratio Mouth Neoplasms neutrophil‐to‐lymphocyte ratio Oral cancer Oral carcinoma Oral squamous cell carcinoma Patients Prognosis Retrospective Studies Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck survival Survival analysis systemic inflammation response index Tumors |
| title | The systemic inflammation response index predicts the survival of patients with clinical T1‐2N0 oral squamous cell carcinoma |
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