Upregulation of KIF11 in TP53 Mutant Glioma Promotes Tumor Stemness and Drug Resistance

Glioma is the most common type of primary brain malignancy with high morbidity and mortality, but little is known about its pathological mechanisms. Kinesin family member 11 (KIF11) is a key driver of malignancy in glioblastoma, a grade IV glioma, but its involvement in glioma chemoresistance remain...

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Veröffentlicht in:	Cellular and molecular neurobiology 2022-07, Vol.42 (5), p.1477-1485
Hauptverfasser:	Liu, Bin, Zhang, Gang, Cui, Shukun, Du, Guoliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain tumors Cell Biology Cell cycle Cell proliferation Chemoresistance Drug Resistance Glioblastoma Glioma - drug therapy Glioma - genetics Glioma - metabolism Glioma cells Humans Kinesin Kinesins - genetics Morbidity Neoplastic Stem Cells Neurobiology Neurosciences Original Research Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Up-Regulation - genetics
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