Calycosin modulates inflammation via suppressing TLR4/NF‐κB pathway and promotes bone formation to ameliorate glucocorticoid‐induced osteonecrosis of the femoral head in rat

Glucocorticoid (GC) administration is one of the main causes of osteonecrosis of the femoral head (ONFH). Inflammation, especially the TLR4/NF‐κB pathway, has been demonstrated to play a pivotal role in the pathogenesis of GC‐induced ONFH. Calycosin, the main bioactive extract of Astragali Radix, co...

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Veröffentlicht in:	Phytotherapy research 2021-05, Vol.35 (5), p.2824-2835
Hauptverfasser:	Zhu, Daoyu, Yu, Hongping, Liu, Pei, Yang, Qianhao, Chen, Yixuan, Luo, Pengbo, Zhang, Changqing, Gao, Youshui
Format:	Artikel
Sprache:	eng
Schlagworte:	Alizarin Alkaline phosphatase Biomedical materials Bone growth calycosin Cytokines Differentiation (biology) Femur glucocorticoid Glucocorticoids In vivo methods and tests Inflammation Mesenchyme Methylprednisolone Morbidity Osteogenesis Osteonecrosis osteonecrosis of the femoral head Pathogenesis Stem cell transplantation Stem cells TLR4 protein TLR4/NF‐κB pathway Toll-like receptors
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