Circular RNA circNINL promotes breast cancer progression through activating β-catenin signaling via miR-921/ADAM9 axis

Circular RNA circNINL promotes breast cancer progression through activating β-catenin signaling via miR-921/ADAM9 axis

Abstract We investigated the expression and functions of circular RNA (circRNA) circNINL and miR-921 in breast cancer (BC) in this study. We found that the expression of circNINL increased while the expression of miR-921 decreased in BC tissues and cell lines, and their anomalous expressions were as...

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Veröffentlicht in:Journal of biochemistry (Tokyo) 2021-06, Vol.169 (6), p.693-700
Hauptverfasser: Xu, Chuanbo, Yu, Haitao, Yin, Xianghua, Zhang, Jishi, Liu, Chunlin, Qi, Hong, Liu, Peng
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container_end_page 700
container_issue 6
container_start_page 693
container_title Journal of biochemistry (Tokyo)
container_volume 169
creator Xu, Chuanbo
Yu, Haitao
Yin, Xianghua
Zhang, Jishi
Liu, Chunlin
Qi, Hong
Liu, Peng
description Abstract We investigated the expression and functions of circular RNA (circRNA) circNINL and miR-921 in breast cancer (BC) in this study. We found that the expression of circNINL increased while the expression of miR-921 decreased in BC tissues and cell lines, and their anomalous expressions were associated with malignant features and poor prognostic of BC. Then, we demonstrated that circNINL could interact with miR-921 and facilitate BC cells malignant process including proliferation acceleration, migration enhancement and apoptosis evasion via sponging miR-921 in vitro. Further investigations revealed that circNINL/miR-921 axis could mediate the expression of ADAM9 which was a direct target of miR-921. In addition, we exhibited that ADAM9 may activate β-catenin signaling by interacting with E-cadherin. We presented the vital roles of circNINL/miR-921/ADAM9/β-catenin signaling in the progression of BC. Graphical Abstract
doi_str_mv 10.1093/jb/mvab005
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title Circular RNA circNINL promotes breast cancer progression through activating β-catenin signaling via miR-921/ADAM9 axis
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