Breaking the cycle: Targeting of NDRG1 to inhibit bi‐directional oncogenic cross‐talk between pancreatic cancer and stroma

Pancreatic cancer (PaCa) is characterized by dense stroma that hinders treatment efficacy, with pancreatic stellate cells (PSCs) being a major contributor to this stromal barrier and PaCa progression. Activated PSCs release hepatocyte growth factor (HGF) and insulin‐like growth factor (IGF‐1) that i...

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Veröffentlicht in:	The FASEB journal 2021-02, Vol.35 (2), p.e21347-n/a
Hauptverfasser:	Geleta, Bekesho, Park, Kyung Chan, Jansson, Patric J., Sahni, Sumit, Maleki, Sanaz, Xu, Zhihong, Murakami, Takashi, Pajic, Marina, Apte, Minoti V., Richardson, Des R., Kovacevic, Zaklina
Format:	Artikel
Sprache:	eng
Schlagworte:	DpC NDRG1 pancreatic cancer stellate cells stroma
Online-Zugang:	Volltext
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