Optimization of Initial Cation Concentrations for L-Lactic Acid Production from Fructose by Lactobacillus pentosus Cells
In this study, Box-Behnken design was applied to optimize the initial concentrations of 4 cations for L-lactic acid production from fructose by homologous batch fermentation of Lactobacillus pentosus cells. The optimum initial cation concentrations were obtained as 6.542 mM Mg 2+ , 3.765 mM Mn 2+ ,...
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| Veröffentlicht in: | Applied biochemistry and biotechnology 2021-05, Vol.193 (5), p.1496-1512 |
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| creator | Wang, Jianfei Jiang, Shaoming Huang, Jiaqi Guo, Huanyu Bi, Xudong Hou, Maolin Chen, Xingyu Hou, Shibo Lin, Hebei Lu, Yuming Lv, Hujie Qiao, Jinyue Yang, Ruiyi Liu, Shijie |
| description | In this study, Box-Behnken design was applied to optimize the initial concentrations of 4 cations for L-lactic acid production from fructose by homologous batch fermentation of
Lactobacillus pentosus
cells. The optimum initial cation concentrations were obtained as 6.542 mM Mg
2+
, 3.765 mM Mn
2+
, 2.397 mM Cu
2+
, and 3.912 mM Fe
2+
, respectively. The highest L-lactic acid yield and productivity were obtained as 0.935 ± 0.005 g/g fructose and 1.363 ± 0.021 g/(L × h), respectively, with a maximum biomass concentration of 7.97 ± 0.17 g/L. The effectiveness of the optimization by Box-Behnken design was confirmed based on the small errors between predicted results and experimental results shown as 0.3%, − 0.2%, and − 1.2%, respectively. The quadratic models with high accuracy and reliability can be applied to mathematically forecasted the fermentation performance. After the optimization, the lactic acid yield and productivity were significantly improved by 3.7% and 21.0%, respectively. |
| doi_str_mv | 10.1007/s12010-021-03492-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2480326115</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2480326115</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-b40f6eada30c65728da12a9d14238d5b8ab0e4202575a6e777a47c85fe98e9b33</originalsourceid><addsrcrecordid>eNp9kcFu1DAQhi0EotvCC3BAlrhwCXjG9to-VlELlVYqBzhbjuMgV0m82IlE-_S4mwISB3wZz8w3_4z0E_IG2AdgTH0sgAxYwxAaxoXBBp6RHUhpasnAc7JjqHiDqM0ZOS_ljjFALdVLcsa50KK-Hfl5e1ziFB_cEtNM00Bv5rhEN9J2q7Rp9mFe8ikrdEiZHpqD80v09NLHnn7JqV_9iR1ymuh1rlkqgXb39JFLnfNxHNdCj1UnlfppwziWV-TF4MYSXj_FC_Lt-upr-7k53H66aS8PjReAS9MJNuyD6x1nfi8V6t4BOtODQK572WnXsSCQoVTS7YNSygnltRyC0cF0nF-Q95vuMacfayiLnWLx9QI3h7QWi0IzjnsAWdF3_6B3ac1zvc6iBFO3I5hK4Ub5nErJYbDHHCeX7y0w--iL3Xyx1Rd78sVCHXr7JL12U-j_jPw2ogJ8A0ptzd9D_rv7P7K_AOIWmN4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2519572219</pqid></control><display><type>article</type><title>Optimization of Initial Cation Concentrations for L-Lactic Acid Production from Fructose by Lactobacillus pentosus Cells</title><source>SpringerNature Journals</source><creator>Wang, Jianfei ; Jiang, Shaoming ; Huang, Jiaqi ; Guo, Huanyu ; Bi, Xudong ; Hou, Maolin ; Chen, Xingyu ; Hou, Shibo ; Lin, Hebei ; Lu, Yuming ; Lv, Hujie ; Qiao, Jinyue ; Yang, Ruiyi ; Liu, Shijie</creator><creatorcontrib>Wang, Jianfei ; Jiang, Shaoming ; Huang, Jiaqi ; Guo, Huanyu ; Bi, Xudong ; Hou, Maolin ; Chen, Xingyu ; Hou, Shibo ; Lin, Hebei ; Lu, Yuming ; Lv, Hujie ; Qiao, Jinyue ; Yang, Ruiyi ; Liu, Shijie</creatorcontrib><description>In this study, Box-Behnken design was applied to optimize the initial concentrations of 4 cations for L-lactic acid production from fructose by homologous batch fermentation of
Lactobacillus pentosus
cells. The optimum initial cation concentrations were obtained as 6.542 mM Mg
2+
, 3.765 mM Mn
2+
, 2.397 mM Cu
2+
, and 3.912 mM Fe
2+
, respectively. The highest L-lactic acid yield and productivity were obtained as 0.935 ± 0.005 g/g fructose and 1.363 ± 0.021 g/(L × h), respectively, with a maximum biomass concentration of 7.97 ± 0.17 g/L. The effectiveness of the optimization by Box-Behnken design was confirmed based on the small errors between predicted results and experimental results shown as 0.3%, − 0.2%, and − 1.2%, respectively. The quadratic models with high accuracy and reliability can be applied to mathematically forecasted the fermentation performance. After the optimization, the lactic acid yield and productivity were significantly improved by 3.7% and 21.0%, respectively.</description><identifier>ISSN: 0273-2289</identifier><identifier>EISSN: 1559-0291</identifier><identifier>DOI: 10.1007/s12010-021-03492-1</identifier><identifier>PMID: 33484444</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acid production ; Acids ; Biochemistry ; Biotechnology ; Cations ; Chemistry ; Chemistry and Materials Science ; Copper ; Design optimization ; Fermentation ; Fructose ; Homology ; Iron ; Lactic acid ; Lactobacillus pentosus ; Magnesium ; Mathematical models ; Model accuracy ; Optimization ; Original Article ; Productivity</subject><ispartof>Applied biochemistry and biotechnology, 2021-05, Vol.193 (5), p.1496-1512</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-b40f6eada30c65728da12a9d14238d5b8ab0e4202575a6e777a47c85fe98e9b33</citedby><cites>FETCH-LOGICAL-c412t-b40f6eada30c65728da12a9d14238d5b8ab0e4202575a6e777a47c85fe98e9b33</cites><orcidid>0000-0001-9259-1642</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12010-021-03492-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12010-021-03492-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33484444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jianfei</creatorcontrib><creatorcontrib>Jiang, Shaoming</creatorcontrib><creatorcontrib>Huang, Jiaqi</creatorcontrib><creatorcontrib>Guo, Huanyu</creatorcontrib><creatorcontrib>Bi, Xudong</creatorcontrib><creatorcontrib>Hou, Maolin</creatorcontrib><creatorcontrib>Chen, Xingyu</creatorcontrib><creatorcontrib>Hou, Shibo</creatorcontrib><creatorcontrib>Lin, Hebei</creatorcontrib><creatorcontrib>Lu, Yuming</creatorcontrib><creatorcontrib>Lv, Hujie</creatorcontrib><creatorcontrib>Qiao, Jinyue</creatorcontrib><creatorcontrib>Yang, Ruiyi</creatorcontrib><creatorcontrib>Liu, Shijie</creatorcontrib><title>Optimization of Initial Cation Concentrations for L-Lactic Acid Production from Fructose by Lactobacillus pentosus Cells</title><title>Applied biochemistry and biotechnology</title><addtitle>Appl Biochem Biotechnol</addtitle><addtitle>Appl Biochem Biotechnol</addtitle><description>In this study, Box-Behnken design was applied to optimize the initial concentrations of 4 cations for L-lactic acid production from fructose by homologous batch fermentation of
Lactobacillus pentosus
cells. The optimum initial cation concentrations were obtained as 6.542 mM Mg
2+
, 3.765 mM Mn
2+
, 2.397 mM Cu
2+
, and 3.912 mM Fe
2+
, respectively. The highest L-lactic acid yield and productivity were obtained as 0.935 ± 0.005 g/g fructose and 1.363 ± 0.021 g/(L × h), respectively, with a maximum biomass concentration of 7.97 ± 0.17 g/L. The effectiveness of the optimization by Box-Behnken design was confirmed based on the small errors between predicted results and experimental results shown as 0.3%, − 0.2%, and − 1.2%, respectively. The quadratic models with high accuracy and reliability can be applied to mathematically forecasted the fermentation performance. After the optimization, the lactic acid yield and productivity were significantly improved by 3.7% and 21.0%, respectively.</description><subject>Acid production</subject><subject>Acids</subject><subject>Biochemistry</subject><subject>Biotechnology</subject><subject>Cations</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Copper</subject><subject>Design optimization</subject><subject>Fermentation</subject><subject>Fructose</subject><subject>Homology</subject><subject>Iron</subject><subject>Lactic acid</subject><subject>Lactobacillus pentosus</subject><subject>Magnesium</subject><subject>Mathematical models</subject><subject>Model accuracy</subject><subject>Optimization</subject><subject>Original 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Cation Concentrations for L-Lactic Acid Production from Fructose by Lactobacillus pentosus Cells</atitle><jtitle>Applied biochemistry and biotechnology</jtitle><stitle>Appl Biochem Biotechnol</stitle><addtitle>Appl Biochem Biotechnol</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>193</volume><issue>5</issue><spage>1496</spage><epage>1512</epage><pages>1496-1512</pages><issn>0273-2289</issn><eissn>1559-0291</eissn><abstract>In this study, Box-Behnken design was applied to optimize the initial concentrations of 4 cations for L-lactic acid production from fructose by homologous batch fermentation of
Lactobacillus pentosus
cells. The optimum initial cation concentrations were obtained as 6.542 mM Mg
2+
, 3.765 mM Mn
2+
, 2.397 mM Cu
2+
, and 3.912 mM Fe
2+
, respectively. The highest L-lactic acid yield and productivity were obtained as 0.935 ± 0.005 g/g fructose and 1.363 ± 0.021 g/(L × h), respectively, with a maximum biomass concentration of 7.97 ± 0.17 g/L. The effectiveness of the optimization by Box-Behnken design was confirmed based on the small errors between predicted results and experimental results shown as 0.3%, − 0.2%, and − 1.2%, respectively. The quadratic models with high accuracy and reliability can be applied to mathematically forecasted the fermentation performance. After the optimization, the lactic acid yield and productivity were significantly improved by 3.7% and 21.0%, respectively.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33484444</pmid><doi>10.1007/s12010-021-03492-1</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0001-9259-1642</orcidid></addata></record> |
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| subjects | Acid production Acids Biochemistry Biotechnology Cations Chemistry Chemistry and Materials Science Copper Design optimization Fermentation Fructose Homology Iron Lactic acid Lactobacillus pentosus Magnesium Mathematical models Model accuracy Optimization Original Article Productivity |
| title | Optimization of Initial Cation Concentrations for L-Lactic Acid Production from Fructose by Lactobacillus pentosus Cells |
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