Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system

G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for maintaining resting membrane potential, cell excitability and inhibitory neurotransmission. Coupled to numerous G protein-coupled receptors (GPCRs), they mediate the effects of many neurotransmitters, neuromodulator...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 2021-07, Vol.223, p.107808-107808, Article 107808
Hauptverfasser:	Jeremic, Danko, Sanchez-Rodriguez, Irene, Jimenez-Diaz, Lydia, Navarro-Lopez, Juan D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Central Nervous System - physiology Central Nervous System Diseases - drug therapy G Protein-Coupled Inwardly-Rectifying Potassium Channels - pharmacology G Protein-Coupled Inwardly-Rectifying Potassium Channels - physiology G protein-coupled receptor GirK/Kir3 channels Humans Molecular Targeted Therapy Neurological and psychiatric diseases Neuronal excitability New therapeutic targets Signaling
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!