Astragaloside IV protects against podocyte apoptosis by inhibiting oxidative stress via activating PPARγ-Klotho-FoxO1 axis in diabetic nephropathy

Podocyte apoptosis plays an important role in the pathogenesis of diabetic nephropathy (DN). Astragaloside IV (AS-IV) has been shown to protect against podocyte apoptosis. Here we aim to investigate the mechanism responsible for the protective effects of AS-IV. Diabetic db/db mice and high glucose (...

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Veröffentlicht in:	Life sciences (1973) 2021-03, Vol.269, p.119068-119068, Article 119068
Hauptverfasser:	Xing, Lina, Fang, Ji, Zhu, Bingbing, Wang, Li, Chen, Junliang, Wang, Yunman, Huang, Jiebo, Wang, Hao, Yao, Xingmei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Antioxidants Apoptosis Astragaloside IV Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetic Nephropathies - etiology Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic Nephropathies - prevention & control Diabetic nephropathy Evaluation Flow cytometry Forkhead Box Protein O1 - genetics Forkhead Box Protein O1 - metabolism Forkhead protein FoxO1 FOXO1 protein Gene expression Gene Expression Regulation Glucose - metabolism Glucuronidase - genetics Glucuronidase - metabolism Immunofluorescence Inhibitors Klotho Klotho protein Male Mice Mice, Inbred C57BL Mitochondria Molecular modelling Nephropathy Oxidative stress Pathogenesis Podocyte apoptosis Podocytes - drug effects Podocytes - metabolism Podocytes - pathology PPAR gamma - genetics PPAR gamma - metabolism PPARγ Protective Agents Renal function Saponins - pharmacology Signal Transduction siRNA Superoxide Triterpenes - pharmacology
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