Small animal jet injection technique results in enhanced immunogenicity of hantavirus DNA vaccines

DNA vaccine evaluation in small animals is hampered by low immunogenicity when the vaccines are delivered using a needle and syringe. To overcome this technical hurdle we tested the possibility that a device developed for human intradermal medicine delivery might be adapted to successfully deliver a...

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Veröffentlicht in:	Vaccine 2021-02, Vol.39 (7), p.1101-1110
Hauptverfasser:	Brocato, Rebecca L., Kwilas, Steven A., Josleyn, Matthew D., Long, Simon, Zeng, Xiankun, Perley, Casey C., Principe, Lucia M., Somerville, Brandon, Cohen, Melanie V., Hooper, Jay W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Animals Antibodies Antigens Commercialization Cricetinae Deoxyribonucleic acid Dermis DNA DNA vaccine DNA vaccines Fatalities Gene expression Gene guns Hamster, hantavirus Hamsters Hantavirus Hantavirus - genetics Hantavirus Infections - prevention & control Immunization Immunogenicity Immunogenicity, Vaccine Injection Injections, Jet Jet injection Laboratories mRNA stability Muscles Nucleic acids Optimization Plasmids RNA polymerase Syringes Tropis Vaccination - methods Vaccines Vaccines, DNA - administration & dosage Viral Vaccines - administration & dosage Viruses
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