Prediction Model for Screening Patients at Risk of Malnutrition After Gastric Cancer Surgery
Background Malnutrition after gastrectomy is associated with a poor prognosis; however, no accurate model for predicting post-gastrectomy malnutrition exists. Hence, we conducted a retrospective study to develop a prediction model identifying gastric cancer patients at high risk of malnutrition afte...
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| Veröffentlicht in: | Annals of surgical oncology 2021-08, Vol.28 (8), p.4471-4481 |
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| container_title | Annals of surgical oncology |
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| creator | Park, Ji-Hyeon Kim, Eunjung Seol, Eun-Mi Kong, Seong-Ho Park, Do Joong Yang, Han-Kwang Choi, Jong-Ho Park, Shin-Hoo Choe, Hwi-Nyeong Kweon, Meera Park, Jiwon Choi, Yunhee Lee, Hyuk-Joon |
| description | Background
Malnutrition after gastrectomy is associated with a poor prognosis; however, no accurate model for predicting post-gastrectomy malnutrition exists. Hence, we conducted a retrospective study to develop a prediction model identifying gastric cancer patients at high risk of malnutrition after gastrectomy.
Method
Gastric cancer patients who underwent curative gastrectomy with more than one weight measurement during a 3-year follow-up period were included. Malnutrition was defined as body mass index (BMI) |
| doi_str_mv | 10.1245/s10434-020-09559-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2480299651</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2547772851</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-5ef0d56cc081eca2350d911eec90a1fb3dc4863b53b10e7cc94ccab3450265213</originalsourceid><addsrcrecordid>eNp9kMlOwzAQhi0EgrK8AAdkiQuXwHjLcqwqKEggKgo3JMtxJiiQOmAnh749bssiceBke_zNP_ZHyDGDc8aluggMpJAJcEigUKpIxBYZMRVLMs3ZdtxDmicFT9Ue2Q_hFYBlAtQu2RNC5ixmjMjzzGPV2L7pHL3rKmxp3Xk6tx7RNe6FzkzfoOsDNT19aMIb7Wp6Z1o39L5ZN43rHj2dmhALlk6Ms_E4H_wL-uUh2alNG_Doaz0gT1eXj5Pr5PZ-ejMZ3yZWZKpPFNZQqdRayBlaw4WCqmAM0RZgWF2Kyso8FaUSJQPMrC2ktaYUUkH8G2figJxtct999zFg6PWiCRbb1jjshqC5zIEXRapW6Okf9LUbvIuv01zJLMt4vqb4hrK-C8Fjrd99szB-qRnolXu9ca-je712r0VsOvmKHsoFVj8t37IjIDZAiFcuCvqd_U_sJ4TWjnY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2547772851</pqid></control><display><type>article</type><title>Prediction Model for Screening Patients at Risk of Malnutrition After Gastric Cancer Surgery</title><source>SpringerLink Journals</source><creator>Park, Ji-Hyeon ; Kim, Eunjung ; Seol, Eun-Mi ; Kong, Seong-Ho ; Park, Do Joong ; Yang, Han-Kwang ; Choi, Jong-Ho ; Park, Shin-Hoo ; Choe, Hwi-Nyeong ; Kweon, Meera ; Park, Jiwon ; Choi, Yunhee ; Lee, Hyuk-Joon</creator><creatorcontrib>Park, Ji-Hyeon ; Kim, Eunjung ; Seol, Eun-Mi ; Kong, Seong-Ho ; Park, Do Joong ; Yang, Han-Kwang ; Choi, Jong-Ho ; Park, Shin-Hoo ; Choe, Hwi-Nyeong ; Kweon, Meera ; Park, Jiwon ; Choi, Yunhee ; Lee, Hyuk-Joon</creatorcontrib><description>Background
Malnutrition after gastrectomy is associated with a poor prognosis; however, no accurate model for predicting post-gastrectomy malnutrition exists. Hence, we conducted a retrospective study to develop a prediction model identifying gastric cancer patients at high risk of malnutrition after gastrectomy.
Method
Gastric cancer patients who underwent curative gastrectomy with more than one weight measurement during a 3-year follow-up period were included. Malnutrition was defined as body mass index (BMI) < 18.5 kg/m
2
according to the European Society of Clinical Nutrition and Metabolism diagnostic criteria. BMI-loss pattern was analyzed using a group-based trajectory model. A prediction model for malnutrition 6 months after gastrectomy was developed based on significant risk factors, and then validated.
Results
Overall, 1421 patients were examined. The BMI-loss trajectory model showed significant BMI loss at 6 months after gastrectomy. Severe BMI loss (mean 21.5%;
n
= 109) was significantly associated with the elderly, female sex, higher preoperative BMI, advanced cancer stage, open surgery, total gastrectomy, Roux-en-Y reconstruction, chemotherapy, and postoperative complications (all
p
< 0.05). Malnutrition 6 months after gastrectomy was observed in 152 (11.9%) of 1281 patients. Preoperative BMI, sex, and type of operation were included in the final prediction model as predictive factors (
p <
0.05). The C-index of the developmental set and bootstrap validation of the prediction model was 0.91 (95% confidence interval 0.89–0.94) and 0.91, respectively.
Conclusion
The prediction model for the risk of malnutrition 6 months after gastrectomy was accurately developed, with three independent risk factors: low preoperative BMI, female sex, and total or proximal gastrectomy.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-020-09559-3</identifier><identifier>PMID: 33481124</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Body mass index ; Chemotherapy ; Gastrectomy ; Gastric cancer ; Gastrointestinal Oncology ; Gastrointestinal surgery ; Malnutrition ; Medicine ; Medicine & Public Health ; Nutrition therapy ; Oncology ; Patients ; Prediction models ; Risk factors ; Sex ; Surgery ; Surgical Oncology</subject><ispartof>Annals of surgical oncology, 2021-08, Vol.28 (8), p.4471-4481</ispartof><rights>Society of Surgical Oncology 2021</rights><rights>Society of Surgical Oncology 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-5ef0d56cc081eca2350d911eec90a1fb3dc4863b53b10e7cc94ccab3450265213</citedby><cites>FETCH-LOGICAL-c375t-5ef0d56cc081eca2350d911eec90a1fb3dc4863b53b10e7cc94ccab3450265213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-020-09559-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-020-09559-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33481124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Ji-Hyeon</creatorcontrib><creatorcontrib>Kim, Eunjung</creatorcontrib><creatorcontrib>Seol, Eun-Mi</creatorcontrib><creatorcontrib>Kong, Seong-Ho</creatorcontrib><creatorcontrib>Park, Do Joong</creatorcontrib><creatorcontrib>Yang, Han-Kwang</creatorcontrib><creatorcontrib>Choi, Jong-Ho</creatorcontrib><creatorcontrib>Park, Shin-Hoo</creatorcontrib><creatorcontrib>Choe, Hwi-Nyeong</creatorcontrib><creatorcontrib>Kweon, Meera</creatorcontrib><creatorcontrib>Park, Jiwon</creatorcontrib><creatorcontrib>Choi, Yunhee</creatorcontrib><creatorcontrib>Lee, Hyuk-Joon</creatorcontrib><title>Prediction Model for Screening Patients at Risk of Malnutrition After Gastric Cancer Surgery</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Malnutrition after gastrectomy is associated with a poor prognosis; however, no accurate model for predicting post-gastrectomy malnutrition exists. Hence, we conducted a retrospective study to develop a prediction model identifying gastric cancer patients at high risk of malnutrition after gastrectomy.
Method
Gastric cancer patients who underwent curative gastrectomy with more than one weight measurement during a 3-year follow-up period were included. Malnutrition was defined as body mass index (BMI) < 18.5 kg/m
2
according to the European Society of Clinical Nutrition and Metabolism diagnostic criteria. BMI-loss pattern was analyzed using a group-based trajectory model. A prediction model for malnutrition 6 months after gastrectomy was developed based on significant risk factors, and then validated.
Results
Overall, 1421 patients were examined. The BMI-loss trajectory model showed significant BMI loss at 6 months after gastrectomy. Severe BMI loss (mean 21.5%;
n
= 109) was significantly associated with the elderly, female sex, higher preoperative BMI, advanced cancer stage, open surgery, total gastrectomy, Roux-en-Y reconstruction, chemotherapy, and postoperative complications (all
p
< 0.05). Malnutrition 6 months after gastrectomy was observed in 152 (11.9%) of 1281 patients. Preoperative BMI, sex, and type of operation were included in the final prediction model as predictive factors (
p <
0.05). The C-index of the developmental set and bootstrap validation of the prediction model was 0.91 (95% confidence interval 0.89–0.94) and 0.91, respectively.
Conclusion
The prediction model for the risk of malnutrition 6 months after gastrectomy was accurately developed, with three independent risk factors: low preoperative BMI, female sex, and total or proximal gastrectomy.</description><subject>Body mass index</subject><subject>Chemotherapy</subject><subject>Gastrectomy</subject><subject>Gastric cancer</subject><subject>Gastrointestinal Oncology</subject><subject>Gastrointestinal surgery</subject><subject>Malnutrition</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nutrition therapy</subject><subject>Oncology</subject><subject>Patients</subject><subject>Prediction models</subject><subject>Risk factors</subject><subject>Sex</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kMlOwzAQhi0EgrK8AAdkiQuXwHjLcqwqKEggKgo3JMtxJiiQOmAnh749bssiceBke_zNP_ZHyDGDc8aluggMpJAJcEigUKpIxBYZMRVLMs3ZdtxDmicFT9Ue2Q_hFYBlAtQu2RNC5ixmjMjzzGPV2L7pHL3rKmxp3Xk6tx7RNe6FzkzfoOsDNT19aMIb7Wp6Z1o39L5ZN43rHj2dmhALlk6Ms_E4H_wL-uUh2alNG_Doaz0gT1eXj5Pr5PZ-ejMZ3yZWZKpPFNZQqdRayBlaw4WCqmAM0RZgWF2Kyso8FaUSJQPMrC2ktaYUUkH8G2figJxtct999zFg6PWiCRbb1jjshqC5zIEXRapW6Okf9LUbvIuv01zJLMt4vqb4hrK-C8Fjrd99szB-qRnolXu9ca-je712r0VsOvmKHsoFVj8t37IjIDZAiFcuCvqd_U_sJ4TWjnY</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Park, Ji-Hyeon</creator><creator>Kim, Eunjung</creator><creator>Seol, Eun-Mi</creator><creator>Kong, Seong-Ho</creator><creator>Park, Do Joong</creator><creator>Yang, Han-Kwang</creator><creator>Choi, Jong-Ho</creator><creator>Park, Shin-Hoo</creator><creator>Choe, Hwi-Nyeong</creator><creator>Kweon, Meera</creator><creator>Park, Jiwon</creator><creator>Choi, Yunhee</creator><creator>Lee, Hyuk-Joon</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210801</creationdate><title>Prediction Model for Screening Patients at Risk of Malnutrition After Gastric Cancer Surgery</title><author>Park, Ji-Hyeon ; Kim, Eunjung ; Seol, Eun-Mi ; Kong, Seong-Ho ; Park, Do Joong ; Yang, Han-Kwang ; Choi, Jong-Ho ; Park, Shin-Hoo ; Choe, Hwi-Nyeong ; Kweon, Meera ; Park, Jiwon ; Choi, Yunhee ; Lee, Hyuk-Joon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-5ef0d56cc081eca2350d911eec90a1fb3dc4863b53b10e7cc94ccab3450265213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Body mass index</topic><topic>Chemotherapy</topic><topic>Gastrectomy</topic><topic>Gastric cancer</topic><topic>Gastrointestinal Oncology</topic><topic>Gastrointestinal surgery</topic><topic>Malnutrition</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nutrition therapy</topic><topic>Oncology</topic><topic>Patients</topic><topic>Prediction models</topic><topic>Risk factors</topic><topic>Sex</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Ji-Hyeon</creatorcontrib><creatorcontrib>Kim, Eunjung</creatorcontrib><creatorcontrib>Seol, Eun-Mi</creatorcontrib><creatorcontrib>Kong, Seong-Ho</creatorcontrib><creatorcontrib>Park, Do Joong</creatorcontrib><creatorcontrib>Yang, Han-Kwang</creatorcontrib><creatorcontrib>Choi, Jong-Ho</creatorcontrib><creatorcontrib>Park, Shin-Hoo</creatorcontrib><creatorcontrib>Choe, Hwi-Nyeong</creatorcontrib><creatorcontrib>Kweon, Meera</creatorcontrib><creatorcontrib>Park, Jiwon</creatorcontrib><creatorcontrib>Choi, Yunhee</creatorcontrib><creatorcontrib>Lee, Hyuk-Joon</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Ji-Hyeon</au><au>Kim, Eunjung</au><au>Seol, Eun-Mi</au><au>Kong, Seong-Ho</au><au>Park, Do Joong</au><au>Yang, Han-Kwang</au><au>Choi, Jong-Ho</au><au>Park, Shin-Hoo</au><au>Choe, Hwi-Nyeong</au><au>Kweon, Meera</au><au>Park, Jiwon</au><au>Choi, Yunhee</au><au>Lee, Hyuk-Joon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction Model for Screening Patients at Risk of Malnutrition After Gastric Cancer Surgery</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>28</volume><issue>8</issue><spage>4471</spage><epage>4481</epage><pages>4471-4481</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Malnutrition after gastrectomy is associated with a poor prognosis; however, no accurate model for predicting post-gastrectomy malnutrition exists. Hence, we conducted a retrospective study to develop a prediction model identifying gastric cancer patients at high risk of malnutrition after gastrectomy.
Method
Gastric cancer patients who underwent curative gastrectomy with more than one weight measurement during a 3-year follow-up period were included. Malnutrition was defined as body mass index (BMI) < 18.5 kg/m
2
according to the European Society of Clinical Nutrition and Metabolism diagnostic criteria. BMI-loss pattern was analyzed using a group-based trajectory model. A prediction model for malnutrition 6 months after gastrectomy was developed based on significant risk factors, and then validated.
Results
Overall, 1421 patients were examined. The BMI-loss trajectory model showed significant BMI loss at 6 months after gastrectomy. Severe BMI loss (mean 21.5%;
n
= 109) was significantly associated with the elderly, female sex, higher preoperative BMI, advanced cancer stage, open surgery, total gastrectomy, Roux-en-Y reconstruction, chemotherapy, and postoperative complications (all
p
< 0.05). Malnutrition 6 months after gastrectomy was observed in 152 (11.9%) of 1281 patients. Preoperative BMI, sex, and type of operation were included in the final prediction model as predictive factors (
p <
0.05). The C-index of the developmental set and bootstrap validation of the prediction model was 0.91 (95% confidence interval 0.89–0.94) and 0.91, respectively.
Conclusion
The prediction model for the risk of malnutrition 6 months after gastrectomy was accurately developed, with three independent risk factors: low preoperative BMI, female sex, and total or proximal gastrectomy.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33481124</pmid><doi>10.1245/s10434-020-09559-3</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2021-08, Vol.28 (8), p.4471-4481 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2480299651 |
| source | SpringerLink Journals |
| subjects | Body mass index Chemotherapy Gastrectomy Gastric cancer Gastrointestinal Oncology Gastrointestinal surgery Malnutrition Medicine Medicine & Public Health Nutrition therapy Oncology Patients Prediction models Risk factors Sex Surgery Surgical Oncology |
| title | Prediction Model for Screening Patients at Risk of Malnutrition After Gastric Cancer Surgery |
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