Methionine controls insulin/mammalian target of rapamycin complex 1 activity by modulating tuberous sclerosis complex 2 stability

Tuberous sclerosis complex 2 (TSC2) is a tumor-suppressor protein that is partially regulated by insulin, energy, oxygen, and growth factors. Mutations in the TSC2 gene and loss of TSC2 promote cell growth by the mammalian target of rapamycin complex 1 (mTORC1) activation. Furthermore, S-adenosylmet...

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Veröffentlicht in:	Biochemical and biophysical research communications 2021-02, Vol.541, p.84-89
Hauptverfasser:	Gen, Seishu, Matsumoto, Yu, Suzuki, Tsukasa, Inoue, Jun, Yamamoto, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT Amino acid Mammalian target of rapamycin complex 1 Methionine S-adenosylmethionine Tuberous sclerosis complex 2
Online-Zugang:	Volltext
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