Phloridzin attenuates lipopolysaccharide-induced cognitive impairment via antioxidant, anti-inflammatory and neuromodulatory activities

[Display omitted] •Lipopolysaccharide (LPS) administration in mice causes memory impairment.•LPS reduces antioxidants and neurotropic factors in the brain.•LPS increases inflammatory markers and cholinesterase activity in the brain.•Phloridzin reverses the biochemical changes induced by LPS.•Phlorid...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2021-03, Vol.139, p.155408-155408, Article 155408
Hauptverfasser:	Kamdi, Sandesh P., Raval, Amit, Nakhate, Kartik T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Antioxidants - metabolism Cognitive Dysfunction - chemically induced Cognitive Dysfunction - drug therapy Cognitive Dysfunction - metabolism Cytokines Disease Models, Animal Glutathione - metabolism Hippocampus - drug effects Hippocampus - metabolism Lipopolysaccharides - pharmacology Male Maze Learning - drug effects Memory Memory - drug effects Memory Disorders - drug therapy Memory Disorders - metabolism Mice Neuroinflammation Neuroinflammatory Diseases - chemically induced Neuroinflammatory Diseases - drug therapy Neuroinflammatory Diseases - metabolism Neuroprotective Agents - pharmacology Neurotransmitter Agents - metabolism Oxidative Stress - drug effects Phlorhizin - pharmacology Phloridzin Superoxide Dismutase - metabolism Tumor Necrosis Factor-alpha - metabolism
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