Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements

Many genes are regulated by multiple enhancers that often simultaneously activate their target gene. However, how individual enhancers collaborate to activate transcription is not well understood. Here, we dissect the functions and interdependencies of five enhancer elements that together activate F...

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Veröffentlicht in:	Molecular cell 2021-03, Vol.81 (5), p.969-982.e13
Hauptverfasser:	Thomas, Henry F., Kotova, Elena, Jayaram, Swathi, Pilz, Axel, Romeike, Merrit, Lackner, Andreas, Penz, Thomas, Bock, Christoph, Leeb, Martin, Halbritter, Florian, Wysocka, Joanna, Buecker, Christa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Nucleus - genetics Cell Nucleus - metabolism differentiation Drosophila melanogaster - genetics Drosophila melanogaster - metabolism enhancer Enhancer Elements, Genetic Exons Fibroblast Growth Factor 5 - genetics Fibroblast Growth Factor 5 - metabolism Gene Expression Regulation, Developmental Gene Knockout Techniques Genes, Reporter Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Histones - genetics Histones - metabolism Introns Luminescent Proteins - genetics Luminescent Proteins - metabolism Mice Mouse Embryonic Stem Cells - cytology Mouse Embryonic Stem Cells - metabolism pluripotency Promoter Regions, Genetic Red Fluorescent Protein RNA Pol II RNA Polymerase II - genetics RNA Polymerase II - metabolism Sequence Analysis, RNA Signal Transduction Single-Cell Analysis super-enhancer transcription Transcription, Genetic
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