Impaired antibacterial response of liver sinusoidal Vγ9+Vδ2+ T cells in patients with chronic liver disease

ObjectiveThe liver acts as a frontline barrier against diverse gut-derived pathogens, and the sinusoid is the primary site of liver immune surveillance. However, little is known about liver sinusoidal immune cells in the context of chronic liver disease (CLD). Here, we investigated the antibacterial...

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Veröffentlicht in:	Gut 2022-03, Vol.71 (3), p.605-615
Hauptverfasser:	Rha, Min-Seok, Han, Ji Won, Koh, June-Young, Lee, Ha Seok, Kim, Jong Hoon, Cho, Kyungjoo, Kim, Soon Il, Kim, Myoung Soo, Lee, Jae Geun, Park, Su-Hyung, Joo, Dong Jin, Park, Jun Yong, Shin, Eui-Cheol
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Apoptosis Bacteria Bacterial infections bacterial translocation Case-Control Studies Chronic Disease chronic liver disease Cirrhosis Endotoxins - blood Escherichia coli Escherichia coli - physiology Female Flow cytometry gamma-delta cells Genotype & phenotype Hepatitis Hepatocellular carcinoma Hepatocytes Hepatology Humans Immunology Immunosurveillance Lactic acid Lactic Acid - blood Liver cirrhosis Liver diseases Liver Diseases - blood Liver Diseases - immunology Liver Diseases - pathology liver immunology Liver Transplantation Lymphocytes Lymphocytes T Male Pathogens Phenotypes Plasma levels T-Lymphocytes - physiology Transcriptomics Tumor necrosis factor-TNF γ-Interferon
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