Silver-Catalyzed Radical Cascade Sulfonation/Cycloaddition for the Construction of Multifunctional Succimides Containing Separable Z/E‑Isomers

Silver-Catalyzed Radical Cascade Sulfonation/Cycloaddition for the Construction of Multifunctional Succimides Containing Separable Z/E‑Isomers

A silver-catalyzed cascade cycloaddition of aza-1,6-enynes, affording multifunctional succimide frameworks initiated by the arylsulfonyl radical addition, has been developed. This process shows mild reaction conditions, excellent structural selectivity, and broad functional group tolerance. In addit...

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Veröffentlicht in:Journal of organic chemistry 2021-02, Vol.86 (3), p.2173-2183
Hauptverfasser: Gu, Yan, Dai, Lei, Zhang, Jinghang, Lu, Xinchi, Liu, Xiaoqin, Wang, Chang, Zhang, Jinpeng, Rong, Liangce
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container_issue 3
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container_title Journal of organic chemistry
container_volume 86
creator Gu, Yan
Dai, Lei
Zhang, Jinghang
Lu, Xinchi
Liu, Xiaoqin
Wang, Chang
Zhang, Jinpeng
Rong, Liangce
description A silver-catalyzed cascade cycloaddition of aza-1,6-enynes, affording multifunctional succimide frameworks initiated by the arylsulfonyl radical addition, has been developed. This process shows mild reaction conditions, excellent structural selectivity, and broad functional group tolerance. In addition, the Z/E-isomers can be easily separated, which provides an efficient method for obtaining pure Z/E-configuration products.
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title Silver-Catalyzed Radical Cascade Sulfonation/Cycloaddition for the Construction of Multifunctional Succimides Containing Separable Z/E‑Isomers
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