Incidence of ocular inflammation among patients with active tuberculosis or nontuberculous mycobacterial infections in a tertiary hospital in Japan
Purpose This study aimed to elucidate the incidence of ocular involvement among patients with active tuberculosis (TB) or nontuberculous mycobacterial (NTM) infection in a hospital in Japan. Methods Patients with active TB or NTM infection at Yoshijima Hospital from April 2017 to July 2018 were incl...
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| Veröffentlicht in: | International ophthalmology 2021-04, Vol.41 (4), p.1427-1436 |
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| creator | Ohara, Hiromi Harada, Yosuke Hiyama, Tomona Yamane, Ken Higaki, Maria Kobayashi, Takayuki Ikegami, Yasuhiko Yuasa, Yuki Kiuchi, Yoshiaki |
| description | Purpose
This study aimed to elucidate the incidence of ocular involvement among patients with active tuberculosis (TB) or nontuberculous mycobacterial (NTM) infection in a hospital in Japan.
Methods
Patients with active TB or NTM infection at Yoshijima Hospital from April 2017 to July 2018 were included in this retrospective study. All patients underwent ophthalmic examinations, including fundus evaluation under pupil dilation, before initiation of antibiotic therapy. Patients with ocular inflammation were regularly followed up by ophthalmologists.
Results
In total, 101 patients with active TB and 27 patients with active NTM infection underwent ophthalmic examinations during the study period. Seven patients with TB (6.9%) had ocular inflammation; four had bilateral involvement. In these seven patients, ocular inflammation comprised anterior uveitis (
n
= 2), intermediate uveitis (
n
= 1), posterior uveitis (
n
= 4). Choroidal tubercles were observed in two patients with posterior uveitis. Female sex was associated with higher incidence of ocular inflammation among patients with TB. Conversely, no patients with NTM infection had ocular inflammation.
Conclusion
Ocular inflammation was present in approximately 7% of patients with active TB. Although TB choroiditis is presumed to be rare in Japan, approximately 30% of the patients with ocular inflammation exhibited choroidal lesions in this study. In contrast, no ocular inflammation was observed among patients with systemic NTM infection. |
| doi_str_mv | 10.1007/s10792-021-01718-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2479709601</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2510493692</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-7d12b911f80a86908a69759ab75550d0174e666869153b2ab20b1e37d1837ff13</originalsourceid><addsrcrecordid>eNp9kcFuFSEUhonR2Gv1BVwYEjduRg9wgWFpGm1rmrjRNWG4TEszAyMwNu1r-MKe21tr4sIVcPj-n3P4CXnN4D0D0B8qA214B5x1wDTru7snZMOkFh1XAp6SDTAlO6mBHZEXtV4DgNFGPSdHQmy1NNBvyK_z5OMuJB9oHmn26-QKjWmc3Dy7FnOibs7pki54CKlVehPbFXW-xZ-BtnUIBSW5xkpzoSmnx9Ja6Xzr84BoKNFNe9Pg944Vt9RRLLfoyi29ynWJ7Z6gX9zi0kvybHRTDa8e1mPy_fOnbydn3cXX0_OTjxedF1y1Tu8YHwxjYw-uVziNUwancoOWUsIOv2QblFJ4xaQYuBs4DCwIlPVCjyMTx-TdwXcp-ccaarNzrD5Mk0sB-7d8q40Go2CPvv0Hvc5rSdid5ZLB1ghlOFL8QPmSay1htEuJM85oGdh9ZPYQmcXI7H1k9g5Fbx6s12EOu0fJn4wQEAeg4lW6DOXv2_-x_Q1lf6Q_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2510493692</pqid></control><display><type>article</type><title>Incidence of ocular inflammation among patients with active tuberculosis or nontuberculous mycobacterial infections in a tertiary hospital in Japan</title><source>SpringerLink Journals - AutoHoldings</source><creator>Ohara, Hiromi ; Harada, Yosuke ; Hiyama, Tomona ; Yamane, Ken ; Higaki, Maria ; Kobayashi, Takayuki ; Ikegami, Yasuhiko ; Yuasa, Yuki ; Kiuchi, Yoshiaki</creator><creatorcontrib>Ohara, Hiromi ; Harada, Yosuke ; Hiyama, Tomona ; Yamane, Ken ; Higaki, Maria ; Kobayashi, Takayuki ; Ikegami, Yasuhiko ; Yuasa, Yuki ; Kiuchi, Yoshiaki</creatorcontrib><description>Purpose
This study aimed to elucidate the incidence of ocular involvement among patients with active tuberculosis (TB) or nontuberculous mycobacterial (NTM) infection in a hospital in Japan.
Methods
Patients with active TB or NTM infection at Yoshijima Hospital from April 2017 to July 2018 were included in this retrospective study. All patients underwent ophthalmic examinations, including fundus evaluation under pupil dilation, before initiation of antibiotic therapy. Patients with ocular inflammation were regularly followed up by ophthalmologists.
Results
In total, 101 patients with active TB and 27 patients with active NTM infection underwent ophthalmic examinations during the study period. Seven patients with TB (6.9%) had ocular inflammation; four had bilateral involvement. In these seven patients, ocular inflammation comprised anterior uveitis (
n
= 2), intermediate uveitis (
n
= 1), posterior uveitis (
n
= 4). Choroidal tubercles were observed in two patients with posterior uveitis. Female sex was associated with higher incidence of ocular inflammation among patients with TB. Conversely, no patients with NTM infection had ocular inflammation.
Conclusion
Ocular inflammation was present in approximately 7% of patients with active TB. Although TB choroiditis is presumed to be rare in Japan, approximately 30% of the patients with ocular inflammation exhibited choroidal lesions in this study. In contrast, no ocular inflammation was observed among patients with systemic NTM infection.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-021-01718-z</identifier><identifier>PMID: 33475908</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Antibiotics ; Choroiditis ; Infections ; Inflammation ; Medicine ; Medicine & Public Health ; Ophthalmology ; Original Paper ; Tuberculosis ; Uveitis</subject><ispartof>International ophthalmology, 2021-04, Vol.41 (4), p.1427-1436</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-7d12b911f80a86908a69759ab75550d0174e666869153b2ab20b1e37d1837ff13</cites><orcidid>0000-0001-9827-4963</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-021-01718-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-021-01718-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33475908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohara, Hiromi</creatorcontrib><creatorcontrib>Harada, Yosuke</creatorcontrib><creatorcontrib>Hiyama, Tomona</creatorcontrib><creatorcontrib>Yamane, Ken</creatorcontrib><creatorcontrib>Higaki, Maria</creatorcontrib><creatorcontrib>Kobayashi, Takayuki</creatorcontrib><creatorcontrib>Ikegami, Yasuhiko</creatorcontrib><creatorcontrib>Yuasa, Yuki</creatorcontrib><creatorcontrib>Kiuchi, Yoshiaki</creatorcontrib><title>Incidence of ocular inflammation among patients with active tuberculosis or nontuberculous mycobacterial infections in a tertiary hospital in Japan</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
This study aimed to elucidate the incidence of ocular involvement among patients with active tuberculosis (TB) or nontuberculous mycobacterial (NTM) infection in a hospital in Japan.
Methods
Patients with active TB or NTM infection at Yoshijima Hospital from April 2017 to July 2018 were included in this retrospective study. All patients underwent ophthalmic examinations, including fundus evaluation under pupil dilation, before initiation of antibiotic therapy. Patients with ocular inflammation were regularly followed up by ophthalmologists.
Results
In total, 101 patients with active TB and 27 patients with active NTM infection underwent ophthalmic examinations during the study period. Seven patients with TB (6.9%) had ocular inflammation; four had bilateral involvement. In these seven patients, ocular inflammation comprised anterior uveitis (
n
= 2), intermediate uveitis (
n
= 1), posterior uveitis (
n
= 4). Choroidal tubercles were observed in two patients with posterior uveitis. Female sex was associated with higher incidence of ocular inflammation among patients with TB. Conversely, no patients with NTM infection had ocular inflammation.
Conclusion
Ocular inflammation was present in approximately 7% of patients with active TB. Although TB choroiditis is presumed to be rare in Japan, approximately 30% of the patients with ocular inflammation exhibited choroidal lesions in this study. In contrast, no ocular inflammation was observed among patients with systemic NTM infection.</description><subject>Antibiotics</subject><subject>Choroiditis</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><subject>Tuberculosis</subject><subject>Uveitis</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kcFuFSEUhonR2Gv1BVwYEjduRg9wgWFpGm1rmrjRNWG4TEszAyMwNu1r-MKe21tr4sIVcPj-n3P4CXnN4D0D0B8qA214B5x1wDTru7snZMOkFh1XAp6SDTAlO6mBHZEXtV4DgNFGPSdHQmy1NNBvyK_z5OMuJB9oHmn26-QKjWmc3Dy7FnOibs7pki54CKlVehPbFXW-xZ-BtnUIBSW5xkpzoSmnx9Ja6Xzr84BoKNFNe9Pg944Vt9RRLLfoyi29ynWJ7Z6gX9zi0kvybHRTDa8e1mPy_fOnbydn3cXX0_OTjxedF1y1Tu8YHwxjYw-uVziNUwancoOWUsIOv2QblFJ4xaQYuBs4DCwIlPVCjyMTx-TdwXcp-ccaarNzrD5Mk0sB-7d8q40Go2CPvv0Hvc5rSdid5ZLB1ghlOFL8QPmSay1htEuJM85oGdh9ZPYQmcXI7H1k9g5Fbx6s12EOu0fJn4wQEAeg4lW6DOXv2_-x_Q1lf6Q_</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Ohara, Hiromi</creator><creator>Harada, Yosuke</creator><creator>Hiyama, Tomona</creator><creator>Yamane, Ken</creator><creator>Higaki, Maria</creator><creator>Kobayashi, Takayuki</creator><creator>Ikegami, Yasuhiko</creator><creator>Yuasa, Yuki</creator><creator>Kiuchi, Yoshiaki</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9827-4963</orcidid></search><sort><creationdate>20210401</creationdate><title>Incidence of ocular inflammation among patients with active tuberculosis or nontuberculous mycobacterial infections in a tertiary hospital in Japan</title><author>Ohara, Hiromi ; Harada, Yosuke ; Hiyama, Tomona ; Yamane, Ken ; Higaki, Maria ; Kobayashi, Takayuki ; Ikegami, Yasuhiko ; Yuasa, Yuki ; Kiuchi, Yoshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-7d12b911f80a86908a69759ab75550d0174e666869153b2ab20b1e37d1837ff13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antibiotics</topic><topic>Choroiditis</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><topic>Tuberculosis</topic><topic>Uveitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohara, Hiromi</creatorcontrib><creatorcontrib>Harada, Yosuke</creatorcontrib><creatorcontrib>Hiyama, Tomona</creatorcontrib><creatorcontrib>Yamane, Ken</creatorcontrib><creatorcontrib>Higaki, Maria</creatorcontrib><creatorcontrib>Kobayashi, Takayuki</creatorcontrib><creatorcontrib>Ikegami, Yasuhiko</creatorcontrib><creatorcontrib>Yuasa, Yuki</creatorcontrib><creatorcontrib>Kiuchi, Yoshiaki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohara, Hiromi</au><au>Harada, Yosuke</au><au>Hiyama, Tomona</au><au>Yamane, Ken</au><au>Higaki, Maria</au><au>Kobayashi, Takayuki</au><au>Ikegami, Yasuhiko</au><au>Yuasa, Yuki</au><au>Kiuchi, Yoshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of ocular inflammation among patients with active tuberculosis or nontuberculous mycobacterial infections in a tertiary hospital in Japan</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>41</volume><issue>4</issue><spage>1427</spage><epage>1436</epage><pages>1427-1436</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
This study aimed to elucidate the incidence of ocular involvement among patients with active tuberculosis (TB) or nontuberculous mycobacterial (NTM) infection in a hospital in Japan.
Methods
Patients with active TB or NTM infection at Yoshijima Hospital from April 2017 to July 2018 were included in this retrospective study. All patients underwent ophthalmic examinations, including fundus evaluation under pupil dilation, before initiation of antibiotic therapy. Patients with ocular inflammation were regularly followed up by ophthalmologists.
Results
In total, 101 patients with active TB and 27 patients with active NTM infection underwent ophthalmic examinations during the study period. Seven patients with TB (6.9%) had ocular inflammation; four had bilateral involvement. In these seven patients, ocular inflammation comprised anterior uveitis (
n
= 2), intermediate uveitis (
n
= 1), posterior uveitis (
n
= 4). Choroidal tubercles were observed in two patients with posterior uveitis. Female sex was associated with higher incidence of ocular inflammation among patients with TB. Conversely, no patients with NTM infection had ocular inflammation.
Conclusion
Ocular inflammation was present in approximately 7% of patients with active TB. Although TB choroiditis is presumed to be rare in Japan, approximately 30% of the patients with ocular inflammation exhibited choroidal lesions in this study. In contrast, no ocular inflammation was observed among patients with systemic NTM infection.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>33475908</pmid><doi>10.1007/s10792-021-01718-z</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9827-4963</orcidid></addata></record> |
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| ispartof | International ophthalmology, 2021-04, Vol.41 (4), p.1427-1436 |
| issn | 0165-5701 1573-2630 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Antibiotics Choroiditis Infections Inflammation Medicine Medicine & Public Health Ophthalmology Original Paper Tuberculosis Uveitis |
| title | Incidence of ocular inflammation among patients with active tuberculosis or nontuberculous mycobacterial infections in a tertiary hospital in Japan |
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