Do Near-Infrared Intra-Operative Findings Obtained Using Indocyanine Green Correlate with Post-Thyroidectomy Parathyroid Function? the Icgpredict Study
Postoperative hypoparathyroidism (hypoPT) still remains a significant complication after thyroidectomy. Intra-operative imaging modalities, such as near-infrared fluorescence using indocyanine green (ICG), may assist in identifying and preserving the parathyroid glands (PGs). The purpose of this stu...
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| Veröffentlicht in: | Endocrine practice 2020-09, Vol.26 (9), p.967-973 |
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| creator | Papavramidis, Theodosios S Anagnostis, Panagiotis Chorti, Angeliki Pliakos, Ioannis Panidis, Stavros Koutsoumparis, Dimitris Michalopoulos, Antonios |
| description | Postoperative hypoparathyroidism (hypoPT) still remains a significant complication after thyroidectomy. Intra-operative imaging modalities, such as near-infrared fluorescence using indocyanine green (ICG), may assist in identifying and preserving the parathyroid glands (PGs). The purpose of this study was to test the association between the intra-operative ICG staining scoring system and 24-hour postoperative parathyroid hormone (PTH) levels, as well as its capability for intra-operative PG identification.
This was a prospective study, recruiting patients scheduled for total thyroidectomy by the same surgical team, from December 2018 to April 2019. Intra-operative angiography was performed after infusion of ICG solution (5 mg). Two minutes later, images were acquired using the near-infrared system.
Sixty patients fulfilled the eligibility criteria. The percentage of temporary postoperative hypoPT (defined as PTH |
| doi_str_mv | 10.4158/EP-2020-0119 |
| format | Article |
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This was a prospective study, recruiting patients scheduled for total thyroidectomy by the same surgical team, from December 2018 to April 2019. Intra-operative angiography was performed after infusion of ICG solution (5 mg). Two minutes later, images were acquired using the near-infrared system.
Sixty patients fulfilled the eligibility criteria. The percentage of temporary postoperative hypoPT (defined as PTH <14 pg/mL) was 11.66%. No association between intra-operative ICG staining score (expressed as the number of PGs scoring <2 per patient) and 24-hour postoperative PTH (r = 0.011; P = .933) or serum calcium concentrations (r = 0.127; P = .335) was observed. There was also no correlation between the location of PGs scoring ≤2 and postoperative PTH (P = .257) or serum calcium levels (P = .950). Moreover, with regard to secondary endpoint, ICG correctly identified PGs in 98.3% of cases. ICG score was not affected by age, gender, duration of operation, or thyroid gland pathology. No allergic reactions attributed to ICG administration were observed.
The intra-operative ICG staining scoring system did not predict 24-hour postoperative PTH and serum calcium levels. However, this modality may assist in intra-operative PG identification during a total thyroidectomy.</description><identifier>ISSN: 1530-891X</identifier><identifier>EISSN: 1934-2403</identifier><identifier>DOI: 10.4158/EP-2020-0119</identifier><identifier>PMID: 33471701</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Age ; Gender ; Humans ; Hypoparathyroidism - etiology ; Indocyanine Green ; Medical imaging ; Parathyroid Glands - diagnostic imaging ; Parathyroid Glands - surgery ; Parathyroid Hormone ; Pathology ; Patients ; Postoperative Complications ; Prospective Studies ; Regression analysis ; Surgeons ; Thyroid diseases ; Thyroidectomy ; Thyroidectomy - adverse effects</subject><ispartof>Endocrine practice, 2020-09, Vol.26 (9), p.967-973</ispartof><rights>2020 American Association of Clinical Endocrinologists. Published by Elsevier, Inc. All rights reserved.</rights><rights>Copyright Allen Press Publishing Services Sep 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c234t-6a87b66f842ae52a7a7e574d7612ee9728c96a3df8fcd03c60481b1859ea6d9a3</citedby><cites>FETCH-LOGICAL-c234t-6a87b66f842ae52a7a7e574d7612ee9728c96a3df8fcd03c60481b1859ea6d9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2447280676?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72341</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33471701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papavramidis, Theodosios S</creatorcontrib><creatorcontrib>Anagnostis, Panagiotis</creatorcontrib><creatorcontrib>Chorti, Angeliki</creatorcontrib><creatorcontrib>Pliakos, Ioannis</creatorcontrib><creatorcontrib>Panidis, Stavros</creatorcontrib><creatorcontrib>Koutsoumparis, Dimitris</creatorcontrib><creatorcontrib>Michalopoulos, Antonios</creatorcontrib><title>Do Near-Infrared Intra-Operative Findings Obtained Using Indocyanine Green Correlate with Post-Thyroidectomy Parathyroid Function? the Icgpredict Study</title><title>Endocrine practice</title><addtitle>Endocr Pract</addtitle><description>Postoperative hypoparathyroidism (hypoPT) still remains a significant complication after thyroidectomy. Intra-operative imaging modalities, such as near-infrared fluorescence using indocyanine green (ICG), may assist in identifying and preserving the parathyroid glands (PGs). The purpose of this study was to test the association between the intra-operative ICG staining scoring system and 24-hour postoperative parathyroid hormone (PTH) levels, as well as its capability for intra-operative PG identification.
This was a prospective study, recruiting patients scheduled for total thyroidectomy by the same surgical team, from December 2018 to April 2019. Intra-operative angiography was performed after infusion of ICG solution (5 mg). Two minutes later, images were acquired using the near-infrared system.
Sixty patients fulfilled the eligibility criteria. The percentage of temporary postoperative hypoPT (defined as PTH <14 pg/mL) was 11.66%. No association between intra-operative ICG staining score (expressed as the number of PGs scoring <2 per patient) and 24-hour postoperative PTH (r = 0.011; P = .933) or serum calcium concentrations (r = 0.127; P = .335) was observed. There was also no correlation between the location of PGs scoring ≤2 and postoperative PTH (P = .257) or serum calcium levels (P = .950). Moreover, with regard to secondary endpoint, ICG correctly identified PGs in 98.3% of cases. ICG score was not affected by age, gender, duration of operation, or thyroid gland pathology. No allergic reactions attributed to ICG administration were observed.
The intra-operative ICG staining scoring system did not predict 24-hour postoperative PTH and serum calcium levels. However, this modality may assist in intra-operative PG identification during a total thyroidectomy.</description><subject>Age</subject><subject>Gender</subject><subject>Humans</subject><subject>Hypoparathyroidism - etiology</subject><subject>Indocyanine Green</subject><subject>Medical imaging</subject><subject>Parathyroid Glands - diagnostic imaging</subject><subject>Parathyroid Glands - surgery</subject><subject>Parathyroid Hormone</subject><subject>Pathology</subject><subject>Patients</subject><subject>Postoperative Complications</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Surgeons</subject><subject>Thyroid diseases</subject><subject>Thyroidectomy</subject><subject>Thyroidectomy - adverse effects</subject><issn>1530-891X</issn><issn>1934-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0UFvFCEYBmBiNLZWb54NiRcPRWFgBjgZs-7WTRp3E9vE24SFb7o0u7AFxmZ-iX9XNls9eAK-PHk_kheht4x-FKxVn-Zr0tCGEsqYfobOmeaCNILy5_XeckqUZj_P0Kuc72llmqmX6IxzIZmk7Bz9_hrxdzCJLMOQTAKHl6EkQ1YHSKb4X4AXPjgf7jJebYrxoYrbXN_VuWgnE-oIXyWAgGcxJdiZAvjRly1ex1zIzXZK0TuwJe4nvDY19DTBizHY4mP4jMsW8NLeHep2bwv-UUY3vUYvBrPL8ObpvEC3i_nN7Bu5Xl0tZ1-uiW24KKQzSm66blCiMdA2RhoJrRROdqwB0LJRVneGu0EN1lFuOyoU2zDVajCd04ZfoA-n3EOKDyPk0u99trDbmQBxzH0jpJZUt0JU-v4_eh_HFOrvqhJ1Fe1kV9XlSdkUc04w9Ifk9yZNPaP9sbB-vu6PhfXHwip_9xQ6bvbg_uG_DfE_bgaSIg</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Papavramidis, Theodosios S</creator><creator>Anagnostis, Panagiotis</creator><creator>Chorti, Angeliki</creator><creator>Pliakos, Ioannis</creator><creator>Panidis, Stavros</creator><creator>Koutsoumparis, Dimitris</creator><creator>Michalopoulos, Antonios</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>202009</creationdate><title>Do Near-Infrared Intra-Operative Findings Obtained Using Indocyanine Green Correlate with Post-Thyroidectomy Parathyroid Function? the Icgpredict Study</title><author>Papavramidis, Theodosios S ; Anagnostis, Panagiotis ; Chorti, Angeliki ; Pliakos, Ioannis ; Panidis, Stavros ; Koutsoumparis, Dimitris ; Michalopoulos, Antonios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c234t-6a87b66f842ae52a7a7e574d7612ee9728c96a3df8fcd03c60481b1859ea6d9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Gender</topic><topic>Humans</topic><topic>Hypoparathyroidism - etiology</topic><topic>Indocyanine Green</topic><topic>Medical imaging</topic><topic>Parathyroid Glands - diagnostic imaging</topic><topic>Parathyroid Glands - surgery</topic><topic>Parathyroid Hormone</topic><topic>Pathology</topic><topic>Patients</topic><topic>Postoperative Complications</topic><topic>Prospective Studies</topic><topic>Regression analysis</topic><topic>Surgeons</topic><topic>Thyroid diseases</topic><topic>Thyroidectomy</topic><topic>Thyroidectomy - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Papavramidis, Theodosios S</creatorcontrib><creatorcontrib>Anagnostis, Panagiotis</creatorcontrib><creatorcontrib>Chorti, Angeliki</creatorcontrib><creatorcontrib>Pliakos, Ioannis</creatorcontrib><creatorcontrib>Panidis, Stavros</creatorcontrib><creatorcontrib>Koutsoumparis, Dimitris</creatorcontrib><creatorcontrib>Michalopoulos, Antonios</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papavramidis, Theodosios S</au><au>Anagnostis, Panagiotis</au><au>Chorti, Angeliki</au><au>Pliakos, Ioannis</au><au>Panidis, Stavros</au><au>Koutsoumparis, Dimitris</au><au>Michalopoulos, Antonios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do Near-Infrared Intra-Operative Findings Obtained Using Indocyanine Green Correlate with Post-Thyroidectomy Parathyroid Function? the Icgpredict Study</atitle><jtitle>Endocrine practice</jtitle><addtitle>Endocr Pract</addtitle><date>2020-09</date><risdate>2020</risdate><volume>26</volume><issue>9</issue><spage>967</spage><epage>973</epage><pages>967-973</pages><issn>1530-891X</issn><eissn>1934-2403</eissn><abstract>Postoperative hypoparathyroidism (hypoPT) still remains a significant complication after thyroidectomy. Intra-operative imaging modalities, such as near-infrared fluorescence using indocyanine green (ICG), may assist in identifying and preserving the parathyroid glands (PGs). The purpose of this study was to test the association between the intra-operative ICG staining scoring system and 24-hour postoperative parathyroid hormone (PTH) levels, as well as its capability for intra-operative PG identification.
This was a prospective study, recruiting patients scheduled for total thyroidectomy by the same surgical team, from December 2018 to April 2019. Intra-operative angiography was performed after infusion of ICG solution (5 mg). Two minutes later, images were acquired using the near-infrared system.
Sixty patients fulfilled the eligibility criteria. The percentage of temporary postoperative hypoPT (defined as PTH <14 pg/mL) was 11.66%. No association between intra-operative ICG staining score (expressed as the number of PGs scoring <2 per patient) and 24-hour postoperative PTH (r = 0.011; P = .933) or serum calcium concentrations (r = 0.127; P = .335) was observed. There was also no correlation between the location of PGs scoring ≤2 and postoperative PTH (P = .257) or serum calcium levels (P = .950). Moreover, with regard to secondary endpoint, ICG correctly identified PGs in 98.3% of cases. ICG score was not affected by age, gender, duration of operation, or thyroid gland pathology. No allergic reactions attributed to ICG administration were observed.
The intra-operative ICG staining scoring system did not predict 24-hour postoperative PTH and serum calcium levels. However, this modality may assist in intra-operative PG identification during a total thyroidectomy.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>33471701</pmid><doi>10.4158/EP-2020-0119</doi><tpages>7</tpages></addata></record> |
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| subjects | Age Gender Humans Hypoparathyroidism - etiology Indocyanine Green Medical imaging Parathyroid Glands - diagnostic imaging Parathyroid Glands - surgery Parathyroid Hormone Pathology Patients Postoperative Complications Prospective Studies Regression analysis Surgeons Thyroid diseases Thyroidectomy Thyroidectomy - adverse effects |
| title | Do Near-Infrared Intra-Operative Findings Obtained Using Indocyanine Green Correlate with Post-Thyroidectomy Parathyroid Function? the Icgpredict Study |
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