Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells

IL-6 affects tissue protective/reparative and inflammatory properties of vascular endothelial cells (ECs). This cytokine can signal to cells through classic and trans-signaling mechanisms, which are differentiated based on the expression of IL-6 receptor (IL-6R) on the surface of target cells. The b...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2021-04, Vol.320 (4), p.C554-C565
Hauptverfasser:	Montgomery, Ashani, Tam, Franklin, Gursche, Chris, Cheneval, Catherine, Besler, Katrina, Enns, Winnie, Manku, Sukhkbir, Rey, Kevin, Hanson, Paul J, Rose-John, Stefan, McManus, Bruce M, Choy, Jonathan C
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adult Aged AKT protein Animals Aorta, Abdominal - drug effects Aorta, Abdominal - metabolism Aorta, Abdominal - pathology Aorta, Abdominal - transplantation Cell culture Cell death Cells, Cultured Coronary artery Cytokine Receptor gp130 - agonists Cytokine Receptor gp130 - metabolism Disease Models, Animal Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Endothelial Cells - transplantation Extracellular signal-regulated kinase Female Graft rejection Graft Rejection - metabolism Graft Rejection - pathology Graft Rejection - prevention & control Heart transplantation Humans Inflammation Inflammation Mediators - metabolism Interleukin 6 Interleukin 6 receptors Interleukin-6 - pharmacology Leukocytes (neutrophilic) Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Middle Aged Monocyte chemoattractant protein 1 Receptors, Interleukin-6 - agonists Receptors, Interleukin-6 - metabolism Signal Transduction Stat3 protein
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