Theaflavin protects chondrocytes against apoptosis and senescence via regulating Nrf2 and ameliorates murine osteoarthritis

Oxidative stress-mediated excessive apoptosis and senescence of chondrocytes are the main pathological alterations in the osteoarthritis (OA) development. The protective effects of theaflavin (TF), a common group of polyphenols in black tea, against many degenerative diseases by attenuating oxidativ...

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Veröffentlicht in:	Food & function 2021-03, Vol.12 (4), p.1590-1602
Hauptverfasser:	Xu, Xin-Xian, Zheng, Gang, Tang, Shang-Kun, Liu, Hai-Xiao, Hu, Yue-Zheng, Shang, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Arthritis Biomedical materials Black tea Butyl hydroperoxide Catabolism Chondrocytes Degenerative diseases Enzyme-linked immunosorbent assay Oral administration Osteoarthritis Oxidative stress Polyphenols Senescence Staining
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