Surprising impact of stromal TIL’s on immunotherapy efficacy in a real-world lung cancer study

•Real world datasets are needed to assess biomarker performances in daily routine practice.•The stromal CD8+TILs were found to be the strongest predictor for PFS and OS in advanced NSCLC on anti-PD-1 monotherapy.•The combination of stromal CD8+TILs, albumin and LDH best predicted OS. Immune checkpoi...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2021-03, Vol.153, p.81-89
Hauptverfasser:	Hashemi, S., Fransen, M.F., Niemeijer, A., Ben Taleb, N., Houda, I., Veltman, J., Becker- Commissaris, A., Daniels, H., Crombag, L., Radonic, T., Jongeneel, G., Tarasevych, S., Looysen, E., van Laren, M., Tiemessen, M., van Diepen, V., Maassen-van den Brink, K., Thunnissen, E., Bahce, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Checkpoint inhibitors Immunotherapy Non-small cell lung cancer Stroma TIL Tumor infiltrating lymphocytes
Online-Zugang:	Volltext
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