Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

Even though supplemental oxygen is used for the treatment of patients with hypoxemic respiratory failure, the most effective oxygenation targets are not known. In this randomized trial, a lower oxygenation target did not result in lower mortality than a higher target.

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Veröffentlicht in:	The New England journal of medicine 2021-04, Vol.384 (14), p.1301-1311
Hauptverfasser:	Schjørring, Olav L, Klitgaard, Thomas L, Perner, Anders, Wetterslev, Jørn, Lange, Theis, Siegemund, Martin, Bäcklund, Minna, Keus, Frederik, Laake, Jon H, Morgan, Matthew, Thormar, Katrin M, Rosborg, Søren A, Bisgaard, Jannie, Erntgaard, Annette E.S, Lynnerup, Anne-Sofie H, Pedersen, Rasmus L, Crescioli, Elena, Gielstrup, Theis C, Behzadi, Meike T, Poulsen, Lone M, Estrup, Stine, Laigaard, Jens P, Andersen, Cheme, Mortensen, Camilla B, Brand, Björn A, White, Jonathan, Jarnvig, Inge-Lise, Møller, Morten H, Quist, Lars, Bestle, Morten H, Schønemann-Lund, Martin, Kamper, Maj K, Hindborg, Mathias, Hollinger, Alexa, Gebhard, Caroline E, Zellweger, Núria, Meyhoff, Christian S, Hjort, Mathias, Bech, Laura K, Grøfte, Thorbjørn, Bundgaard, Helle, Østergaard, Lars H.M, Thyø, Maria A, Hildebrandt, Thomas, Uslu, Bülent, Sølling, Christoffer G, Møller-Nielsen, Nette, Brøchner, Anne C, Borup, Morten, Okkonen, Marjatta, Dieperink, Willem, Pedersen, Ulf G, Andreasen, Anne S, Buus, Lone, Aslam, Tayyba N, Winding, Robert R, Schefold, Joerg C, Thorup, Stine B, Iversen, Susanne A, Engstrøm, Janus, Kjær, Maj-Brit N, Rasmussen, Bodil S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Blood pressure Chronic obstructive pulmonary disease Clinical medicine Clinical trials Confidence intervals Consent Female Generalized linear models Humans Hypoxia - blood Hypoxia - etiology Hypoxia - therapy Intensive care Intensive Care Units Intestine Ischemia Kaplan-Meier Estimate Male Middle Aged Mortality Myocardial ischemia Oxygen Oxygen - administration & dosage Oxygen - blood Oxygen Inhalation Therapy - methods Oxygen saturation Oxygen therapy Oxygenation Patients Respiration, Artificial - methods Respiratory Distress Syndrome - blood Respiratory Distress Syndrome - mortality Respiratory Distress Syndrome - therapy Respiratory failure Respiratory Insufficiency - blood Respiratory Insufficiency - complications Respiratory Insufficiency - mortality Respiratory Insufficiency - therapy Ventilators
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Beschreibung
Zusammenfassung:	Even though supplemental oxygen is used for the treatment of patients with hypoxemic respiratory failure, the most effective oxygenation targets are not known. In this randomized trial, a lower oxygenation target did not result in lower mortality than a higher target.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2032510