Stromal DLK1 promotes proliferation and inhibits differentiation of the intestinal epithelium during development

The stem/progenitor cells of the developing intestine are biologically distinct from their adult counterparts. Here, we examine the microenvironmental cues that regulate the embryonic stem/progenitor population, focusing on the role of Notch pathway factor delta-like protein-1 (DLK1). mRNA-seq analy...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2021-04, Vol.320 (4), p.G506-G520
Hauptverfasser:	Ichinose, Mari, Suzuki, Nobumi, Wang, Tongtong, Wright, Josephine A, Lannagan, Tamsin R M, Vrbanac, Laura, Kobayashi, Hiroki, Gieniec, Krystyna A, Ng, Jia Q, Hayakawa, Yoku, García-Gallastegui, Patricia, Monsalve, Eva M, Bauer, Steven R, Laborda, Jorge, García-Ramírez, J J, Ibarretxe, Gaskon, Worthley, Daniel L, Woods, Susan L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Binding Proteins - deficiency Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cell Communication Cell Differentiation Cell Lineage Cell Proliferation Cells, Cultured Coculture Techniques Embryo cells Embryonic Stem Cells - enzymology Epithelial cells Epithelial Cells - enzymology Epithelium Gene Expression Regulation, Developmental Immunocytochemistry Immunohistochemistry Intestinal Mucosa - embryology Intestinal Mucosa - enzymology Intestine Mesenchyme Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Organoids Phenotypes Preadipocyte factor 1 Progenitor cells Secretory Pathway Signal Transduction siRNA Stem Cell Niche Stem cells Stroma Stromal Cells - enzymology Transcriptome
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