Cross‐talk Between Histone and DNA Methylation Mediates Bone Loss in Hind Limb Unloading

ABSTRACT Bone loss induced by mechanical unloading is a common skeletal disease, but the precise mechanism remains unclear. The current study investigated the role of histone methylation, a key epigenetic marker, and its cross‐talk with DNA methylation in bone loss induced by mechanical unloading. T...

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Veröffentlicht in:	Journal of bone and mineral research 2021-05, Vol.36 (5), p.956-967
Hauptverfasser:	Li, Bing, Zhao, Jie, Ma, Jianxiong, Chen, Weibo, Zhou, Ce, Wei, Wuzeng, Li, Shuai, Li, Guomin, Xin, Guosheng, Zhang, Yang, Liu, Jun, Wang, Yinsong, Ma, Xinlong
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone loss CROSS‐TALK Deoxyribonucleic acid DNA DNA METHYLATION DNMT1 protein EPIGENETIC MODIFICATION Epigenetics Gene expression Histone H3 HISTONE METHYLATION Histones LncH19 Lysine MECHANICAL UNLOADING Mineralization Ubiquitin
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