“Compassionate” Cases of the Jarvik 2015 Ventricular Assist Device
The Jarvik 2015 Ventricular Assist Device (VAD) (Jarvik Inc, New York, NY) is the first and currently only continuous-flow VAD specifically designed for small children, and it is being evaluated in the so-called Pump for Kids, Infants, and Neonates (PumpKIN) trial. Due to the strict inclusion criter...
Gespeichert in:
| Veröffentlicht in: | ASAIO journal (1992) 2021-09, Vol.67 (9), p.1036-1043 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1043 |
|---|---|
| container_issue | 9 |
| container_start_page | 1036 |
| container_title | ASAIO journal (1992) |
| container_volume | 67 |
| creator | Spinner, Joseph A. Tunuguntla, Hari P. Tume, Sebastian C. Elias, Barbara A. Mcmullen, Jason John, Rija Choudhry, Swati Price, Jack F. Denfield, Susan W. Dreyer, William J. Adachi, Iki |
| description | The Jarvik 2015 Ventricular Assist Device (VAD) (Jarvik Inc, New York, NY) is the first and currently only continuous-flow VAD specifically designed for small children, and it is being evaluated in the so-called Pump for Kids, Infants, and Neonates (PumpKIN) trial. Due to the strict inclusion criteria of the trial, there have been a group of patients who failed to meet the criteria and therefore received the Jarvik 2015 VAD under the designation of “compassionate use.” This is the same phenomenon seen previously during the Berlin Heart EXCOR trial. While we await the results of the PumpKIN trial, which will report the device performance in a strictly selected population, the compassionate use cases represent actual “real world” experiences. We describe herein our experience of two compassionate use cases. In particular, this report has a special emphasis on the power consumption and hemolysis and inflammatory lab profile of the Jarvik 2015 VAD as hemocompatibility was the primary focus of the developmental and the preclinical phases. |
| doi_str_mv | 10.1097/MAT.0000000000001351 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2479420249</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2479420249</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3522-b451b2c60e2d3112ca1093c21a5c6783674a20580d1935570058c6f113f8c24d3</originalsourceid><addsrcrecordid>eNpdUEtPAjEQboxGEP0HxvToZbHttPs4klV8BOMFjbemdLthZWGx3YV444fon-OXWAQfcS4zk3yPmQ-hU0q6lCTRxX1v2CV_ioKge6hNBcRBwuF5389ExAFLaNhCR869eIwAoIeoBcAjEgJvo_569Z5W07lyrqhmqjbr1QdOlTMOVzmuxwbfKbsoJph5Mn4ys9oWuimVxT3PcDW-NItCm2N0kKvSmZNd76DH_tUwvQkGD9e3aW8QaBCMBSMu6IjpkBiWAaVMK_8KaEaV0GEUQxhxxfzRJKMJCBERP-swpxTyWDOeQQedb3XntnptjKvltHDalKWamapxkvEo4Ywwnngo30K1rZyzJpdzW0yVfZOUyE2C0ico_yfoaWc7h2Y0NdkP6TuyX91lVdbGuknZLI2VY6PKevylx3hMAn-EN_FbsFFm8Am5_Hms</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2479420249</pqid></control><display><type>article</type><title>“Compassionate” Cases of the Jarvik 2015 Ventricular Assist Device</title><source>MEDLINE</source><source>Journals@Ovid LWW Legacy Archive</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Spinner, Joseph A. ; Tunuguntla, Hari P. ; Tume, Sebastian C. ; Elias, Barbara A. ; Mcmullen, Jason ; John, Rija ; Choudhry, Swati ; Price, Jack F. ; Denfield, Susan W. ; Dreyer, William J. ; Adachi, Iki</creator><creatorcontrib>Spinner, Joseph A. ; Tunuguntla, Hari P. ; Tume, Sebastian C. ; Elias, Barbara A. ; Mcmullen, Jason ; John, Rija ; Choudhry, Swati ; Price, Jack F. ; Denfield, Susan W. ; Dreyer, William J. ; Adachi, Iki</creatorcontrib><description>The Jarvik 2015 Ventricular Assist Device (VAD) (Jarvik Inc, New York, NY) is the first and currently only continuous-flow VAD specifically designed for small children, and it is being evaluated in the so-called Pump for Kids, Infants, and Neonates (PumpKIN) trial. Due to the strict inclusion criteria of the trial, there have been a group of patients who failed to meet the criteria and therefore received the Jarvik 2015 VAD under the designation of “compassionate use.” This is the same phenomenon seen previously during the Berlin Heart EXCOR trial. While we await the results of the PumpKIN trial, which will report the device performance in a strictly selected population, the compassionate use cases represent actual “real world” experiences. We describe herein our experience of two compassionate use cases. In particular, this report has a special emphasis on the power consumption and hemolysis and inflammatory lab profile of the Jarvik 2015 VAD as hemocompatibility was the primary focus of the developmental and the preclinical phases.</description><identifier>ISSN: 1058-2916</identifier><identifier>EISSN: 1538-943X</identifier><identifier>DOI: 10.1097/MAT.0000000000001351</identifier><identifier>PMID: 33470634</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Child ; Clinical Trials as Topic ; Heart Failure - surgery ; Heart-Assist Devices ; Hemolysis ; Humans ; Infant ; Infant, Newborn</subject><ispartof>ASAIO journal (1992), 2021-09, Vol.67 (9), p.1036-1043</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © ASAIO 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3522-b451b2c60e2d3112ca1093c21a5c6783674a20580d1935570058c6f113f8c24d3</citedby><cites>FETCH-LOGICAL-c3522-b451b2c60e2d3112ca1093c21a5c6783674a20580d1935570058c6f113f8c24d3</cites><orcidid>0000-0003-4206-7257 ; 0000-0002-8582-4759 ; 0000-0001-9539-6252 ; 0000-0003-1121-4461</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00002480-202109000-00012$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,778,782,4597,27907,27908,65214</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33470634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spinner, Joseph A.</creatorcontrib><creatorcontrib>Tunuguntla, Hari P.</creatorcontrib><creatorcontrib>Tume, Sebastian C.</creatorcontrib><creatorcontrib>Elias, Barbara A.</creatorcontrib><creatorcontrib>Mcmullen, Jason</creatorcontrib><creatorcontrib>John, Rija</creatorcontrib><creatorcontrib>Choudhry, Swati</creatorcontrib><creatorcontrib>Price, Jack F.</creatorcontrib><creatorcontrib>Denfield, Susan W.</creatorcontrib><creatorcontrib>Dreyer, William J.</creatorcontrib><creatorcontrib>Adachi, Iki</creatorcontrib><title>“Compassionate” Cases of the Jarvik 2015 Ventricular Assist Device</title><title>ASAIO journal (1992)</title><addtitle>ASAIO J</addtitle><description>The Jarvik 2015 Ventricular Assist Device (VAD) (Jarvik Inc, New York, NY) is the first and currently only continuous-flow VAD specifically designed for small children, and it is being evaluated in the so-called Pump for Kids, Infants, and Neonates (PumpKIN) trial. Due to the strict inclusion criteria of the trial, there have been a group of patients who failed to meet the criteria and therefore received the Jarvik 2015 VAD under the designation of “compassionate use.” This is the same phenomenon seen previously during the Berlin Heart EXCOR trial. While we await the results of the PumpKIN trial, which will report the device performance in a strictly selected population, the compassionate use cases represent actual “real world” experiences. We describe herein our experience of two compassionate use cases. In particular, this report has a special emphasis on the power consumption and hemolysis and inflammatory lab profile of the Jarvik 2015 VAD as hemocompatibility was the primary focus of the developmental and the preclinical phases.</description><subject>Child</subject><subject>Clinical Trials as Topic</subject><subject>Heart Failure - surgery</subject><subject>Heart-Assist Devices</subject><subject>Hemolysis</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><issn>1058-2916</issn><issn>1538-943X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUEtPAjEQboxGEP0HxvToZbHttPs4klV8BOMFjbemdLthZWGx3YV444fon-OXWAQfcS4zk3yPmQ-hU0q6lCTRxX1v2CV_ioKge6hNBcRBwuF5389ExAFLaNhCR869eIwAoIeoBcAjEgJvo_569Z5W07lyrqhmqjbr1QdOlTMOVzmuxwbfKbsoJph5Mn4ys9oWuimVxT3PcDW-NItCm2N0kKvSmZNd76DH_tUwvQkGD9e3aW8QaBCMBSMu6IjpkBiWAaVMK_8KaEaV0GEUQxhxxfzRJKMJCBERP-swpxTyWDOeQQedb3XntnptjKvltHDalKWamapxkvEo4Ywwnngo30K1rZyzJpdzW0yVfZOUyE2C0ico_yfoaWc7h2Y0NdkP6TuyX91lVdbGuknZLI2VY6PKevylx3hMAn-EN_FbsFFm8Am5_Hms</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Spinner, Joseph A.</creator><creator>Tunuguntla, Hari P.</creator><creator>Tume, Sebastian C.</creator><creator>Elias, Barbara A.</creator><creator>Mcmullen, Jason</creator><creator>John, Rija</creator><creator>Choudhry, Swati</creator><creator>Price, Jack F.</creator><creator>Denfield, Susan W.</creator><creator>Dreyer, William J.</creator><creator>Adachi, Iki</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4206-7257</orcidid><orcidid>https://orcid.org/0000-0002-8582-4759</orcidid><orcidid>https://orcid.org/0000-0001-9539-6252</orcidid><orcidid>https://orcid.org/0000-0003-1121-4461</orcidid></search><sort><creationdate>20210901</creationdate><title>“Compassionate” Cases of the Jarvik 2015 Ventricular Assist Device</title><author>Spinner, Joseph A. ; Tunuguntla, Hari P. ; Tume, Sebastian C. ; Elias, Barbara A. ; Mcmullen, Jason ; John, Rija ; Choudhry, Swati ; Price, Jack F. ; Denfield, Susan W. ; Dreyer, William J. ; Adachi, Iki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3522-b451b2c60e2d3112ca1093c21a5c6783674a20580d1935570058c6f113f8c24d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Child</topic><topic>Clinical Trials as Topic</topic><topic>Heart Failure - surgery</topic><topic>Heart-Assist Devices</topic><topic>Hemolysis</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spinner, Joseph A.</creatorcontrib><creatorcontrib>Tunuguntla, Hari P.</creatorcontrib><creatorcontrib>Tume, Sebastian C.</creatorcontrib><creatorcontrib>Elias, Barbara A.</creatorcontrib><creatorcontrib>Mcmullen, Jason</creatorcontrib><creatorcontrib>John, Rija</creatorcontrib><creatorcontrib>Choudhry, Swati</creatorcontrib><creatorcontrib>Price, Jack F.</creatorcontrib><creatorcontrib>Denfield, Susan W.</creatorcontrib><creatorcontrib>Dreyer, William J.</creatorcontrib><creatorcontrib>Adachi, Iki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ASAIO journal (1992)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spinner, Joseph A.</au><au>Tunuguntla, Hari P.</au><au>Tume, Sebastian C.</au><au>Elias, Barbara A.</au><au>Mcmullen, Jason</au><au>John, Rija</au><au>Choudhry, Swati</au><au>Price, Jack F.</au><au>Denfield, Susan W.</au><au>Dreyer, William J.</au><au>Adachi, Iki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>“Compassionate” Cases of the Jarvik 2015 Ventricular Assist Device</atitle><jtitle>ASAIO journal (1992)</jtitle><addtitle>ASAIO J</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>67</volume><issue>9</issue><spage>1036</spage><epage>1043</epage><pages>1036-1043</pages><issn>1058-2916</issn><eissn>1538-943X</eissn><abstract>The Jarvik 2015 Ventricular Assist Device (VAD) (Jarvik Inc, New York, NY) is the first and currently only continuous-flow VAD specifically designed for small children, and it is being evaluated in the so-called Pump for Kids, Infants, and Neonates (PumpKIN) trial. Due to the strict inclusion criteria of the trial, there have been a group of patients who failed to meet the criteria and therefore received the Jarvik 2015 VAD under the designation of “compassionate use.” This is the same phenomenon seen previously during the Berlin Heart EXCOR trial. While we await the results of the PumpKIN trial, which will report the device performance in a strictly selected population, the compassionate use cases represent actual “real world” experiences. We describe herein our experience of two compassionate use cases. In particular, this report has a special emphasis on the power consumption and hemolysis and inflammatory lab profile of the Jarvik 2015 VAD as hemocompatibility was the primary focus of the developmental and the preclinical phases.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>33470634</pmid><doi>10.1097/MAT.0000000000001351</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4206-7257</orcidid><orcidid>https://orcid.org/0000-0002-8582-4759</orcidid><orcidid>https://orcid.org/0000-0001-9539-6252</orcidid><orcidid>https://orcid.org/0000-0003-1121-4461</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-2916 |
| ispartof | ASAIO journal (1992), 2021-09, Vol.67 (9), p.1036-1043 |
| issn | 1058-2916 1538-943X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2479420249 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Child Clinical Trials as Topic Heart Failure - surgery Heart-Assist Devices Hemolysis Humans Infant Infant, Newborn |
| title | “Compassionate” Cases of the Jarvik 2015 Ventricular Assist Device |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T16%3A21%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=%E2%80%9CCompassionate%E2%80%9D%20Cases%20of%20the%20Jarvik%202015%20Ventricular%20Assist%20Device&rft.jtitle=ASAIO%20journal%20(1992)&rft.au=Spinner,%20Joseph%20A.&rft.date=2021-09-01&rft.volume=67&rft.issue=9&rft.spage=1036&rft.epage=1043&rft.pages=1036-1043&rft.issn=1058-2916&rft.eissn=1538-943X&rft_id=info:doi/10.1097/MAT.0000000000001351&rft_dat=%3Cproquest_cross%3E2479420249%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2479420249&rft_id=info:pmid/33470634&rfr_iscdi=true |