Excess mortality persists in patients with rheumatoid arthritis
Objectives To investigate the causes and risk of death in a large cohort of Korean patients with rheumatoid arthritis (RA). Methods Patients in the Hanyang BAE (Bae registry of Autoimmune diseases for Epidemiology) RA cohort who fulfilled the American College of Rheumatology criteria were analyzed....
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| Veröffentlicht in: | International journal of rheumatic diseases 2021-03, Vol.24 (3), p.364-372 |
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| container_title | International journal of rheumatic diseases |
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| creator | Lee, Yeon‐Kyung Ahn, Ga Young Lee, Jiyoung Shin, Jung‐Min Lee, Tae‐Han Park, Dae Jin Song, Yeo‐Jin Kim, Mi Kyung Bae, Sang‐Cheol |
| description | Objectives
To investigate the causes and risk of death in a large cohort of Korean patients with rheumatoid arthritis (RA).
Methods
Patients in the Hanyang BAE (Bae registry of Autoimmune diseases for Epidemiology) RA cohort who fulfilled the American College of Rheumatology criteria were analyzed. A total of 2355 patients were enrolled from October 2001 to December 2015. Mortality data were derived by linking with data from the Korean National Statistical Office. Standardized mortality ratio was estimated by dividing observed deaths by expected number of deaths in the general population.
Results
Over the observation period, 225 deaths were reported. Total age‐ and sex‐adjusted standardized mortality ratio was 1.65 (95% confidence interval 1.44‐1.87). The most common cause of death was malignancy (40 cases; 17.8%), followed by respiratory disease (38 cases; 16.9%) and cardiovascular disease (32 cases; 14.2%). Mortality rate and causes of death differed according to year and age of RA onset. Compared with survivors, individuals who died were more likely to be male, smokers, diagnosed with RA at an older age, and to have long disease duration, higher erythrocyte sedimentation rate and C‐reactive protein, higher rheumatoid factor positivity rate, more severe radiographic damage, and more comorbidities.
Conclusion
The mortality rate of patients with RA remains higher than that of the general population. Therefore, to improve the survival of patients with RA, attention should be paid to the management of comorbidities as well as to the RA itself. |
| doi_str_mv | 10.1111/1756-185X.14058 |
| format | Article |
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To investigate the causes and risk of death in a large cohort of Korean patients with rheumatoid arthritis (RA).
Methods
Patients in the Hanyang BAE (Bae registry of Autoimmune diseases for Epidemiology) RA cohort who fulfilled the American College of Rheumatology criteria were analyzed. A total of 2355 patients were enrolled from October 2001 to December 2015. Mortality data were derived by linking with data from the Korean National Statistical Office. Standardized mortality ratio was estimated by dividing observed deaths by expected number of deaths in the general population.
Results
Over the observation period, 225 deaths were reported. Total age‐ and sex‐adjusted standardized mortality ratio was 1.65 (95% confidence interval 1.44‐1.87). The most common cause of death was malignancy (40 cases; 17.8%), followed by respiratory disease (38 cases; 16.9%) and cardiovascular disease (32 cases; 14.2%). Mortality rate and causes of death differed according to year and age of RA onset. Compared with survivors, individuals who died were more likely to be male, smokers, diagnosed with RA at an older age, and to have long disease duration, higher erythrocyte sedimentation rate and C‐reactive protein, higher rheumatoid factor positivity rate, more severe radiographic damage, and more comorbidities.
Conclusion
The mortality rate of patients with RA remains higher than that of the general population. Therefore, to improve the survival of patients with RA, attention should be paid to the management of comorbidities as well as to the RA itself.</description><identifier>ISSN: 1756-1841</identifier><identifier>EISSN: 1756-185X</identifier><identifier>DOI: 10.1111/1756-185X.14058</identifier><identifier>PMID: 33463890</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Autoimmune diseases ; Cardiovascular diseases ; Cohort analysis ; cohort studies ; Death ; Disease ; Epidemiology ; Erythrocyte sedimentation rate ; Malignancy ; Mortality ; Respiratory diseases ; Rheumatoid arthritis ; Rheumatoid factor ; Sex ratio</subject><ispartof>International journal of rheumatic diseases, 2021-03, Vol.24 (3), p.364-372</ispartof><rights>2021 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd</rights><rights>2021 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.</rights><rights>International Journal of Rheumatic Diseases © 2021 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3718-922ac5514a881700473443f7b6d7160f9eabde4a777931f6fe628cf7d31bb0e43</citedby><cites>FETCH-LOGICAL-c3718-922ac5514a881700473443f7b6d7160f9eabde4a777931f6fe628cf7d31bb0e43</cites><orcidid>0000-0003-4658-1093</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1756-185X.14058$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1756-185X.14058$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33463890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Yeon‐Kyung</creatorcontrib><creatorcontrib>Ahn, Ga Young</creatorcontrib><creatorcontrib>Lee, Jiyoung</creatorcontrib><creatorcontrib>Shin, Jung‐Min</creatorcontrib><creatorcontrib>Lee, Tae‐Han</creatorcontrib><creatorcontrib>Park, Dae Jin</creatorcontrib><creatorcontrib>Song, Yeo‐Jin</creatorcontrib><creatorcontrib>Kim, Mi Kyung</creatorcontrib><creatorcontrib>Bae, Sang‐Cheol</creatorcontrib><title>Excess mortality persists in patients with rheumatoid arthritis</title><title>International journal of rheumatic diseases</title><addtitle>Int J Rheum Dis</addtitle><description>Objectives
To investigate the causes and risk of death in a large cohort of Korean patients with rheumatoid arthritis (RA).
Methods
Patients in the Hanyang BAE (Bae registry of Autoimmune diseases for Epidemiology) RA cohort who fulfilled the American College of Rheumatology criteria were analyzed. A total of 2355 patients were enrolled from October 2001 to December 2015. Mortality data were derived by linking with data from the Korean National Statistical Office. Standardized mortality ratio was estimated by dividing observed deaths by expected number of deaths in the general population.
Results
Over the observation period, 225 deaths were reported. Total age‐ and sex‐adjusted standardized mortality ratio was 1.65 (95% confidence interval 1.44‐1.87). The most common cause of death was malignancy (40 cases; 17.8%), followed by respiratory disease (38 cases; 16.9%) and cardiovascular disease (32 cases; 14.2%). Mortality rate and causes of death differed according to year and age of RA onset. Compared with survivors, individuals who died were more likely to be male, smokers, diagnosed with RA at an older age, and to have long disease duration, higher erythrocyte sedimentation rate and C‐reactive protein, higher rheumatoid factor positivity rate, more severe radiographic damage, and more comorbidities.
Conclusion
The mortality rate of patients with RA remains higher than that of the general population. Therefore, to improve the survival of patients with RA, attention should be paid to the management of comorbidities as well as to the RA itself.</description><subject>Autoimmune diseases</subject><subject>Cardiovascular diseases</subject><subject>Cohort analysis</subject><subject>cohort studies</subject><subject>Death</subject><subject>Disease</subject><subject>Epidemiology</subject><subject>Erythrocyte sedimentation rate</subject><subject>Malignancy</subject><subject>Mortality</subject><subject>Respiratory diseases</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><subject>Sex ratio</subject><issn>1756-1841</issn><issn>1756-185X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkM1LwzAYh4Mobk7P3qTgxUu3vM1Xe5Ix5gcM9KDgLaRtyjL6ZZIy99_b2bmDF3PJj_Dk9748CF0DnkJ_ZiAYDyFmH1OgmMUnaHx8OT1mCiN04dwGYw6Ei3M0IoRyEid4jO6XX5l2Lqga61Vp_C5otXXGeReYOmiVN7ru89b4dWDXuquUb0weKOvX1njjLtFZoUqnrw73BL0_LN8WT-Hq5fF5MV-FGREQh0kUqYwxoCqOQWBMBaGUFCLluQCOi0SrNNdUCSESAgUvNI_irBA5gTTFmpIJuht6W9t8dtp5WRmX6bJUtW46JyMqEkyBAevR2z_opuls3W8nI4YxIQnvx0_QbKAy2zhndSFbaypldxKw3LuVe3tyb1L-uO1_3Bx6u7TS-ZH_ldkDbAC2ptS7__rk_HU1FH8DZVuCow</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Lee, Yeon‐Kyung</creator><creator>Ahn, Ga Young</creator><creator>Lee, Jiyoung</creator><creator>Shin, Jung‐Min</creator><creator>Lee, Tae‐Han</creator><creator>Park, Dae Jin</creator><creator>Song, Yeo‐Jin</creator><creator>Kim, Mi Kyung</creator><creator>Bae, Sang‐Cheol</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4658-1093</orcidid></search><sort><creationdate>202103</creationdate><title>Excess mortality persists in patients with rheumatoid arthritis</title><author>Lee, Yeon‐Kyung ; Ahn, Ga Young ; Lee, Jiyoung ; Shin, Jung‐Min ; Lee, Tae‐Han ; Park, Dae Jin ; Song, Yeo‐Jin ; Kim, Mi Kyung ; Bae, Sang‐Cheol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3718-922ac5514a881700473443f7b6d7160f9eabde4a777931f6fe628cf7d31bb0e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Autoimmune diseases</topic><topic>Cardiovascular diseases</topic><topic>Cohort analysis</topic><topic>cohort studies</topic><topic>Death</topic><topic>Disease</topic><topic>Epidemiology</topic><topic>Erythrocyte sedimentation rate</topic><topic>Malignancy</topic><topic>Mortality</topic><topic>Respiratory diseases</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><topic>Sex ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Yeon‐Kyung</creatorcontrib><creatorcontrib>Ahn, Ga Young</creatorcontrib><creatorcontrib>Lee, Jiyoung</creatorcontrib><creatorcontrib>Shin, Jung‐Min</creatorcontrib><creatorcontrib>Lee, Tae‐Han</creatorcontrib><creatorcontrib>Park, Dae Jin</creatorcontrib><creatorcontrib>Song, Yeo‐Jin</creatorcontrib><creatorcontrib>Kim, Mi Kyung</creatorcontrib><creatorcontrib>Bae, Sang‐Cheol</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Yeon‐Kyung</au><au>Ahn, Ga Young</au><au>Lee, Jiyoung</au><au>Shin, Jung‐Min</au><au>Lee, Tae‐Han</au><au>Park, Dae Jin</au><au>Song, Yeo‐Jin</au><au>Kim, Mi Kyung</au><au>Bae, Sang‐Cheol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excess mortality persists in patients with rheumatoid arthritis</atitle><jtitle>International journal of rheumatic diseases</jtitle><addtitle>Int J Rheum Dis</addtitle><date>2021-03</date><risdate>2021</risdate><volume>24</volume><issue>3</issue><spage>364</spage><epage>372</epage><pages>364-372</pages><issn>1756-1841</issn><eissn>1756-185X</eissn><abstract>Objectives
To investigate the causes and risk of death in a large cohort of Korean patients with rheumatoid arthritis (RA).
Methods
Patients in the Hanyang BAE (Bae registry of Autoimmune diseases for Epidemiology) RA cohort who fulfilled the American College of Rheumatology criteria were analyzed. A total of 2355 patients were enrolled from October 2001 to December 2015. Mortality data were derived by linking with data from the Korean National Statistical Office. Standardized mortality ratio was estimated by dividing observed deaths by expected number of deaths in the general population.
Results
Over the observation period, 225 deaths were reported. Total age‐ and sex‐adjusted standardized mortality ratio was 1.65 (95% confidence interval 1.44‐1.87). The most common cause of death was malignancy (40 cases; 17.8%), followed by respiratory disease (38 cases; 16.9%) and cardiovascular disease (32 cases; 14.2%). Mortality rate and causes of death differed according to year and age of RA onset. Compared with survivors, individuals who died were more likely to be male, smokers, diagnosed with RA at an older age, and to have long disease duration, higher erythrocyte sedimentation rate and C‐reactive protein, higher rheumatoid factor positivity rate, more severe radiographic damage, and more comorbidities.
Conclusion
The mortality rate of patients with RA remains higher than that of the general population. Therefore, to improve the survival of patients with RA, attention should be paid to the management of comorbidities as well as to the RA itself.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33463890</pmid><doi>10.1111/1756-185X.14058</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4658-1093</orcidid></addata></record> |
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| subjects | Autoimmune diseases Cardiovascular diseases Cohort analysis cohort studies Death Disease Epidemiology Erythrocyte sedimentation rate Malignancy Mortality Respiratory diseases Rheumatoid arthritis Rheumatoid factor Sex ratio |
| title | Excess mortality persists in patients with rheumatoid arthritis |
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