Role of tryptophan metabolism in cancers and therapeutic implications

Tryptophan (Trp) metabolism is associated with diverse biological processes, including nerve conduction, inflammation, and the immune response. The majority of free Trp is broken down through the kynurenine (Kyn) pathway (KP), in which indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase...

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Veröffentlicht in:	Biochimie 2021-03, Vol.182, p.131-139
Hauptverfasser:	Liu, Xiao-han, Zhai, Xiao-yue
Format:	Artikel
Sprache:	eng
Schlagworte:	Indoleamine-2,3-dioxygenase (IDO) Kynurenine Tryptophan metabolism Tryptophan-2,3-dioxygenase (TDO)
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