Randomized p$p$‐values for multiple testing and their application in replicability analysis

We are concerned with testing replicability hypotheses for many endpoints simultaneously. This constitutes a multiple test problem with composite null hypotheses. Traditional p$p$‐values, which are computed under least favorable parameter configurations (LFCs), are over‐conservative in the case of c...

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Veröffentlicht in:	Biometrical journal 2022-02, Vol.64 (2), p.384-409
Hauptverfasser:	Hoang, Anh‐Tuan, Dickhaus, Thorsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer Simulation Genomics hazard ratio order Hypotheses Mathematical models Meta-analysis Models, Statistical Null hypothesis proportion of true null hypotheses Schweder–Spjøtvoll estimator Statistical analysis Statistical models
Online-Zugang:	Volltext
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