Association between dynapenic abdominal obesity and inflammatory profile in diabetic older community-dwelling patients with end-stage renal disease
Obesity and poor strength impose higher risk factor for end-stage renal disease (ESRD) patients. It is expected that the combination of both conditions might be critically associated with the inflammatory profile in this population, especially in community-dwelling elderly. So, diagnosis of dynapeni...
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| Veröffentlicht in: | Experimental gerontology 2021-04, Vol.146, p.111243-111243, Article 111243 |
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| creator | Corrêa, Hugo de Luca Rosa, Thiago dos Santos Dutra, Maurílio Tiradentes Sales, Marcelo Magalhães Noll, Matias Deus, Lysleine Alves Reis, Andrea Lucena de Araújo, Thaís Branquinho Neves, Rodrigo Vanerson Passos Gadelha, André Bonadias |
| description | Obesity and poor strength impose higher risk factor for end-stage renal disease (ESRD) patients. It is expected that the combination of both conditions might be critically associated with the inflammatory profile in this population, especially in community-dwelling elderly. So, diagnosis of dynapenic obesity and inflammation is an important tool in the management of chronic kidney disease patients at imminent risk of hospitalization.
To investigate the association between dynapenic abdominal obesity and inflammatory markers in community-swelling elderly with ESRD.
Two hundred and forty-seven community-dwelling older patients (66.74 ± 3.20 years; n = 150, 60.73%, males) undergoing maintenance phase hemodialysis volunteered for this study. The study sample was categorized into four groups according to handgrip strength and waist circumference as follows: control, dynapenia (low strength alone), abdominal obesity (high waist circumference alone), and dynapenic obesity (D/AO) (the combination of low strength and high waist circumference). Blood samples were collected for tumor necrosis factor alpha (TNF-α), interleukin (IL)- 6 and IL- 10. Results were considered significant at P |
| doi_str_mv | 10.1016/j.exger.2021.111243 |
| format | Article |
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To investigate the association between dynapenic abdominal obesity and inflammatory markers in community-swelling elderly with ESRD.
Two hundred and forty-seven community-dwelling older patients (66.74 ± 3.20 years; n = 150, 60.73%, males) undergoing maintenance phase hemodialysis volunteered for this study. The study sample was categorized into four groups according to handgrip strength and waist circumference as follows: control, dynapenia (low strength alone), abdominal obesity (high waist circumference alone), and dynapenic obesity (D/AO) (the combination of low strength and high waist circumference). Blood samples were collected for tumor necrosis factor alpha (TNF-α), interleukin (IL)- 6 and IL- 10. Results were considered significant at P < 0.05.
Proportions for control, abdominal obesity, dynapenic, and D/AO were 38.5%, 15.8%, 25.9%, and 19.8%, respectively. Higher concentrations of TNF-α were found in the D/AO group (P < 0.0001). This group also displayed lower levels of IL-10 (P < 0.0001). Further, the D/AO traits were strongly associated with TNF-α and IL-10 (P < 0.0001).
The closely relation between D/AO and inflammatory profile provides evidence that the pooled information of low muscle strength and abdominal obesity may be clinically relevant for the management of ESRD patients.
•D/AO is associated with inflammatory profile in older community-dwelling patients with end-stage renal disease.•D/AO assessment may be clinically relevant for the management of hemodialysis patients.•When in combination, traits of D/AO (dynapenia and obesity) provide worsening of the inflammatory profile.</description><identifier>ISSN: 0531-5565</identifier><identifier>EISSN: 1873-6815</identifier><identifier>DOI: 10.1016/j.exger.2021.111243</identifier><identifier>PMID: 33460716</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Chronic kidney disease ; Dynapenia ; Inflammatory profile ; Obesity</subject><ispartof>Experimental gerontology, 2021-04, Vol.146, p.111243-111243, Article 111243</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-66542f47061ef8cf968d3f9dc60f1689e292f16ce7ad8d5de3cfbf9537862b213</citedby><cites>FETCH-LOGICAL-c359t-66542f47061ef8cf968d3f9dc60f1689e292f16ce7ad8d5de3cfbf9537862b213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.exger.2021.111243$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33460716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Corrêa, Hugo de Luca</creatorcontrib><creatorcontrib>Rosa, Thiago dos Santos</creatorcontrib><creatorcontrib>Dutra, Maurílio Tiradentes</creatorcontrib><creatorcontrib>Sales, Marcelo Magalhães</creatorcontrib><creatorcontrib>Noll, Matias</creatorcontrib><creatorcontrib>Deus, Lysleine Alves</creatorcontrib><creatorcontrib>Reis, Andrea Lucena</creatorcontrib><creatorcontrib>de Araújo, Thaís Branquinho</creatorcontrib><creatorcontrib>Neves, Rodrigo Vanerson Passos</creatorcontrib><creatorcontrib>Gadelha, André Bonadias</creatorcontrib><title>Association between dynapenic abdominal obesity and inflammatory profile in diabetic older community-dwelling patients with end-stage renal disease</title><title>Experimental gerontology</title><addtitle>Exp Gerontol</addtitle><description>Obesity and poor strength impose higher risk factor for end-stage renal disease (ESRD) patients. It is expected that the combination of both conditions might be critically associated with the inflammatory profile in this population, especially in community-dwelling elderly. So, diagnosis of dynapenic obesity and inflammation is an important tool in the management of chronic kidney disease patients at imminent risk of hospitalization.
To investigate the association between dynapenic abdominal obesity and inflammatory markers in community-swelling elderly with ESRD.
Two hundred and forty-seven community-dwelling older patients (66.74 ± 3.20 years; n = 150, 60.73%, males) undergoing maintenance phase hemodialysis volunteered for this study. The study sample was categorized into four groups according to handgrip strength and waist circumference as follows: control, dynapenia (low strength alone), abdominal obesity (high waist circumference alone), and dynapenic obesity (D/AO) (the combination of low strength and high waist circumference). Blood samples were collected for tumor necrosis factor alpha (TNF-α), interleukin (IL)- 6 and IL- 10. Results were considered significant at P < 0.05.
Proportions for control, abdominal obesity, dynapenic, and D/AO were 38.5%, 15.8%, 25.9%, and 19.8%, respectively. Higher concentrations of TNF-α were found in the D/AO group (P < 0.0001). This group also displayed lower levels of IL-10 (P < 0.0001). Further, the D/AO traits were strongly associated with TNF-α and IL-10 (P < 0.0001).
The closely relation between D/AO and inflammatory profile provides evidence that the pooled information of low muscle strength and abdominal obesity may be clinically relevant for the management of ESRD patients.
•D/AO is associated with inflammatory profile in older community-dwelling patients with end-stage renal disease.•D/AO assessment may be clinically relevant for the management of hemodialysis patients.•When in combination, traits of D/AO (dynapenia and obesity) provide worsening of the inflammatory profile.</description><subject>Chronic kidney disease</subject><subject>Dynapenia</subject><subject>Inflammatory profile</subject><subject>Obesity</subject><issn>0531-5565</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kcuOEzEQRS0EYjKPL0BCXrLp4Efb3V6wGI14SSPNZlhbbrscHHXbwXbI5Dv4YRwysGRVVumeuq66CL2hZE0Jle-3a3jaQF4zwuiaUsp6_gKt6DjwTo5UvEQrIjjthJDiAl2WsiWESMbpa3TBeS_JQOUK_botJdlgakgRT1APABG7YzQ7iMFiM7m0hGhmnCYooR6xiQ6H6GezLKamfMS7nHyYoTWxC6aNaFiaHWRs07LsY4M6d4B5DnGDd80IYi34EOp3DNF1pZoN4AwnDxcKmALX6JU3c4Gb53qFvn36-Hj3pbt_-Pz17va-s1yo2kkpeub7gUgKfrReydFxr5yVxFM5KmCKtYeFwbjRCQfc-skrwYdRsolRfoXenee2FX7soVS9hGLbT02EtC-a9YMiXFGumpSfpTanUjJ4vcthMfmoKdGnNPRW_0lDn9LQ5zQa9fbZYD8t4P4xf8_fBB_OAmhr_gwNL7bdx4ILGWzVLoX_GvwGzw2gKw</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Corrêa, Hugo de Luca</creator><creator>Rosa, Thiago dos Santos</creator><creator>Dutra, Maurílio Tiradentes</creator><creator>Sales, Marcelo Magalhães</creator><creator>Noll, Matias</creator><creator>Deus, Lysleine Alves</creator><creator>Reis, Andrea Lucena</creator><creator>de Araújo, Thaís Branquinho</creator><creator>Neves, Rodrigo Vanerson Passos</creator><creator>Gadelha, André Bonadias</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202104</creationdate><title>Association between dynapenic abdominal obesity and inflammatory profile in diabetic older community-dwelling patients with end-stage renal disease</title><author>Corrêa, Hugo de Luca ; Rosa, Thiago dos Santos ; Dutra, Maurílio Tiradentes ; Sales, Marcelo Magalhães ; Noll, Matias ; Deus, Lysleine Alves ; Reis, Andrea Lucena ; de Araújo, Thaís Branquinho ; Neves, Rodrigo Vanerson Passos ; Gadelha, André Bonadias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-66542f47061ef8cf968d3f9dc60f1689e292f16ce7ad8d5de3cfbf9537862b213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chronic kidney disease</topic><topic>Dynapenia</topic><topic>Inflammatory profile</topic><topic>Obesity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Corrêa, Hugo de Luca</creatorcontrib><creatorcontrib>Rosa, Thiago dos Santos</creatorcontrib><creatorcontrib>Dutra, Maurílio Tiradentes</creatorcontrib><creatorcontrib>Sales, Marcelo Magalhães</creatorcontrib><creatorcontrib>Noll, Matias</creatorcontrib><creatorcontrib>Deus, Lysleine Alves</creatorcontrib><creatorcontrib>Reis, Andrea Lucena</creatorcontrib><creatorcontrib>de Araújo, Thaís Branquinho</creatorcontrib><creatorcontrib>Neves, Rodrigo Vanerson Passos</creatorcontrib><creatorcontrib>Gadelha, André Bonadias</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental gerontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corrêa, Hugo de Luca</au><au>Rosa, Thiago dos Santos</au><au>Dutra, Maurílio Tiradentes</au><au>Sales, Marcelo Magalhães</au><au>Noll, Matias</au><au>Deus, Lysleine Alves</au><au>Reis, Andrea Lucena</au><au>de Araújo, Thaís Branquinho</au><au>Neves, Rodrigo Vanerson Passos</au><au>Gadelha, André Bonadias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between dynapenic abdominal obesity and inflammatory profile in diabetic older community-dwelling patients with end-stage renal disease</atitle><jtitle>Experimental gerontology</jtitle><addtitle>Exp Gerontol</addtitle><date>2021-04</date><risdate>2021</risdate><volume>146</volume><spage>111243</spage><epage>111243</epage><pages>111243-111243</pages><artnum>111243</artnum><issn>0531-5565</issn><eissn>1873-6815</eissn><abstract>Obesity and poor strength impose higher risk factor for end-stage renal disease (ESRD) patients. It is expected that the combination of both conditions might be critically associated with the inflammatory profile in this population, especially in community-dwelling elderly. So, diagnosis of dynapenic obesity and inflammation is an important tool in the management of chronic kidney disease patients at imminent risk of hospitalization.
To investigate the association between dynapenic abdominal obesity and inflammatory markers in community-swelling elderly with ESRD.
Two hundred and forty-seven community-dwelling older patients (66.74 ± 3.20 years; n = 150, 60.73%, males) undergoing maintenance phase hemodialysis volunteered for this study. The study sample was categorized into four groups according to handgrip strength and waist circumference as follows: control, dynapenia (low strength alone), abdominal obesity (high waist circumference alone), and dynapenic obesity (D/AO) (the combination of low strength and high waist circumference). Blood samples were collected for tumor necrosis factor alpha (TNF-α), interleukin (IL)- 6 and IL- 10. Results were considered significant at P < 0.05.
Proportions for control, abdominal obesity, dynapenic, and D/AO were 38.5%, 15.8%, 25.9%, and 19.8%, respectively. Higher concentrations of TNF-α were found in the D/AO group (P < 0.0001). This group also displayed lower levels of IL-10 (P < 0.0001). Further, the D/AO traits were strongly associated with TNF-α and IL-10 (P < 0.0001).
The closely relation between D/AO and inflammatory profile provides evidence that the pooled information of low muscle strength and abdominal obesity may be clinically relevant for the management of ESRD patients.
•D/AO is associated with inflammatory profile in older community-dwelling patients with end-stage renal disease.•D/AO assessment may be clinically relevant for the management of hemodialysis patients.•When in combination, traits of D/AO (dynapenia and obesity) provide worsening of the inflammatory profile.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>33460716</pmid><doi>10.1016/j.exger.2021.111243</doi><tpages>1</tpages></addata></record> |
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| ispartof | Experimental gerontology, 2021-04, Vol.146, p.111243-111243, Article 111243 |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Chronic kidney disease Dynapenia Inflammatory profile Obesity |
| title | Association between dynapenic abdominal obesity and inflammatory profile in diabetic older community-dwelling patients with end-stage renal disease |
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