Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation

Purpose Resistance to androgen-deprivation therapies and progression to so-called castrate-resistant prostate cancer (CRPC) remain challenges in prostate cancer (PCa) management and treatment. Among other alterations, CRPC has been associated with metabolic reprogramming driven by androgens. Here, w...

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Veröffentlicht in:	Cellular oncology (Dordrecht) 2021-04, Vol.44 (2), p.385-403
Hauptverfasser:	Cardoso, Henrique J., Figueira, Marília I., Vaz, Cátia V., Carvalho, Tiago M. A., Brás, Luís A., Madureira, Patrícia A., Oliveira, Paulo J., Sardão, Vilma A., Socorro, Sílvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Biomedical and Life Sciences Biomedicine Cancer Research Caspase-3 Cell fate Cell migration Cell proliferation Cell viability Dihydrotestosterone Glutaminase Glutamine Glycolysis Lipid metabolism Metabolism Oncology Original Paper Pathology Prostate cancer
Online-Zugang:	Volltext
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