An Accelerated Wound‐Healing Surgical Suture Engineered with an Extracellular Matrix

A suture is a ubiquitous medical device to hold wounded tissues together and support the healing process after surgery. Surgical sutures, having incomplete biocompatibility, often cause unwanted infections or serious secondary trauma to soft or fragile tissue. In this research, UV/ozone (UVO) irradiation or polystyrene sulfonate acid (PSS) dip‐coating is used to achieve a fibronectin (FN)‐coated absorbable suture system, in which the negatively charged moieties produced on the suture cause fibronectin to change from a soluble plasma form into a fibrous form, mimicking the actions of cellular fibronectin upon binding. The fibrous fibronectin coated on the suture can be exploited as an engineered interface to improve cellular migration and adhesion in the region around the wounded tissue while preventing the binding of infectious bacteria, thereby facilitating wound healing. Furthermore, the FN‐coated suture is found to be associated with a lower friction between the suture and the wounded tissue, thus minimizing the occurrence of secondary wounds during surgery. It is believed that this surface modification can be universally applied to most kinds of sutures currently in use, implying that it may be a novel way to develop a highly effective and safer suture system for clinical applications. By adsorbing fibronectin (FN) onto existing commercial sutures, a novel surgical suture system is developed, accelerating wound healing. The engineered sutures improve cell migration and adhesion at the wounded tissues and prevent bacterial infection. This strategy can be universally applied to most kinds of sutures currently in use, providing a highly effective and safer suture system for clinical applications.