Hybrid Composite of Silver Nanoparticle–Porous Silicon Microparticles as an Image-Guided Localization Agent for Computed Tomography Scan of the Lungs
A hybrid composite of silver nanoparticles (AgNPs) and porous silicon microparticles (pSiMPs) was developed and applied for the computed tomography (CT) scanning of the lungs as an image-guided localization agent. We confirmed the grafting of AgNPs on oxidized pSiMPs template using various analytica...
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| Veröffentlicht in: | ACS biomaterials science & engineering 2020-08, Vol.6 (8), p.4390-4396 |
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| creator | Lee, Eun Mi Lee, Jiyeon Kim, Yejin Yi, Kyung Sik Cho, Janggeun Kim, Jaehoon An, Jong Min Lee, Dahae Kim, Sung Joon An, Eunkyung Hong, Yoo Jin Jo, Hyejung Lee, Seo Hyeon Jung, Yuna Choi, Chi-Hoon Kang, Jae Seung Hur, Jin Kim, Dokyoung |
| description | A hybrid composite of silver nanoparticles (AgNPs) and porous silicon microparticles (pSiMPs) was developed and applied for the computed tomography (CT) scanning of the lungs as an image-guided localization agent. We confirmed the grafting of AgNPs on oxidized pSiMPs template using various analytical equipment, including a scanning electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDS). The hybrid composite showed a high CT contrast intensity (>1000 HU) that enabled us to produce and view images of the lungs. In addition, it showed the ability to maintain a strong CT signal at the injected area of the rabbit’s lungs, up to an hour, without spreading. The lack of toxicity and immune response indicated that the composite could be fully utilized as a new image-guided localization agent of CT scans for lung cancer surgery. |
| doi_str_mv | 10.1021/acsbiomaterials.0c00611 |
| format | Article |
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The lack of toxicity and immune response indicated that the composite could be fully utilized as a new image-guided localization agent of CT scans for lung cancer surgery.</description><identifier>ISSN: 2373-9878</identifier><identifier>EISSN: 2373-9878</identifier><identifier>DOI: 10.1021/acsbiomaterials.0c00611</identifier><identifier>PMID: 33455188</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Lung - diagnostic imaging ; Metal Nanoparticles ; Porosity ; Rabbits ; Silicon ; Silver ; Tomography ; Tomography, X-Ray Computed</subject><ispartof>ACS biomaterials science & engineering, 2020-08, Vol.6 (8), p.4390-4396</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a357t-df86bbfd432caba230cefe11607f0d9133194441eba8439a59fd5dfca396846a3</citedby><cites>FETCH-LOGICAL-a357t-df86bbfd432caba230cefe11607f0d9133194441eba8439a59fd5dfca396846a3</cites><orcidid>0000-0002-7756-3560</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.0c00611$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsbiomaterials.0c00611$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2764,27075,27923,27924,56737,56787</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33455188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Eun Mi</creatorcontrib><creatorcontrib>Lee, Jiyeon</creatorcontrib><creatorcontrib>Kim, Yejin</creatorcontrib><creatorcontrib>Yi, Kyung Sik</creatorcontrib><creatorcontrib>Cho, Janggeun</creatorcontrib><creatorcontrib>Kim, Jaehoon</creatorcontrib><creatorcontrib>An, Jong Min</creatorcontrib><creatorcontrib>Lee, Dahae</creatorcontrib><creatorcontrib>Kim, Sung Joon</creatorcontrib><creatorcontrib>An, Eunkyung</creatorcontrib><creatorcontrib>Hong, Yoo Jin</creatorcontrib><creatorcontrib>Jo, Hyejung</creatorcontrib><creatorcontrib>Lee, Seo Hyeon</creatorcontrib><creatorcontrib>Jung, Yuna</creatorcontrib><creatorcontrib>Choi, Chi-Hoon</creatorcontrib><creatorcontrib>Kang, Jae Seung</creatorcontrib><creatorcontrib>Hur, Jin</creatorcontrib><creatorcontrib>Kim, Dokyoung</creatorcontrib><title>Hybrid Composite of Silver Nanoparticle–Porous Silicon Microparticles as an Image-Guided Localization Agent for Computed Tomography Scan of the Lungs</title><title>ACS biomaterials science & engineering</title><addtitle>ACS Biomater. Sci. Eng</addtitle><description>A hybrid composite of silver nanoparticles (AgNPs) and porous silicon microparticles (pSiMPs) was developed and applied for the computed tomography (CT) scanning of the lungs as an image-guided localization agent. We confirmed the grafting of AgNPs on oxidized pSiMPs template using various analytical equipment, including a scanning electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDS). The hybrid composite showed a high CT contrast intensity (>1000 HU) that enabled us to produce and view images of the lungs. In addition, it showed the ability to maintain a strong CT signal at the injected area of the rabbit’s lungs, up to an hour, without spreading. The lack of toxicity and immune response indicated that the composite could be fully utilized as a new image-guided localization agent of CT scans for lung cancer surgery.</description><subject>Animals</subject><subject>Lung - diagnostic imaging</subject><subject>Metal Nanoparticles</subject><subject>Porosity</subject><subject>Rabbits</subject><subject>Silicon</subject><subject>Silver</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed</subject><issn>2373-9878</issn><issn>2373-9878</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctu1DAUtRCIVkN_Abxkk2LHTuIsqxG0lYaH1LKObuzrqaskDrZTaVjxDyz4P74EDzNUiA2SpWvpvHR0CHnF2TlnJX8DOvbOj5AwOBjiOdOM1Zw_IaelaETRqkY9_et_Qs5ivGeMcaEqKeVzciKErCqu1Cn5cbXrgzN07cfZR5eQektv3PCAgX6Ayc8QktMD_vz2_ZMPfol70Gk_0fdOh0c4UshvotcjbLG4XJxBQzdew-C-QnKZfrHFKVHrw--oJWX81o9-G2C-29EbncU5Od0h3SzTNr4gz2zuhmfHuyKf3729XV8Vm4-X1-uLTQGialJhrKr73hopSg09lIJptMh5zRrLTMuF4G2uzLEHJUULVWtNZawG0dZK1iBW5PXBdw7-y4IxdaOLGocBJsxtu1I2qmkqma1WpDlQc-8YA9puDm6EsOs46_bDdP8M0x2HycqXx5ClH9E86v7MkAniQMgO3b1fwrSX_8_2FyqZpE8</recordid><startdate>20200810</startdate><enddate>20200810</enddate><creator>Lee, Eun Mi</creator><creator>Lee, Jiyeon</creator><creator>Kim, Yejin</creator><creator>Yi, Kyung Sik</creator><creator>Cho, Janggeun</creator><creator>Kim, Jaehoon</creator><creator>An, Jong Min</creator><creator>Lee, Dahae</creator><creator>Kim, Sung Joon</creator><creator>An, Eunkyung</creator><creator>Hong, Yoo Jin</creator><creator>Jo, Hyejung</creator><creator>Lee, Seo Hyeon</creator><creator>Jung, Yuna</creator><creator>Choi, Chi-Hoon</creator><creator>Kang, Jae Seung</creator><creator>Hur, Jin</creator><creator>Kim, Dokyoung</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7756-3560</orcidid></search><sort><creationdate>20200810</creationdate><title>Hybrid Composite of Silver Nanoparticle–Porous Silicon Microparticles as an Image-Guided Localization Agent for Computed Tomography Scan of the Lungs</title><author>Lee, Eun Mi ; Lee, Jiyeon ; Kim, Yejin ; Yi, Kyung Sik ; Cho, Janggeun ; Kim, Jaehoon ; An, Jong Min ; Lee, Dahae ; Kim, Sung Joon ; An, Eunkyung ; Hong, Yoo Jin ; Jo, Hyejung ; Lee, Seo Hyeon ; Jung, Yuna ; Choi, Chi-Hoon ; Kang, Jae Seung ; Hur, Jin ; Kim, Dokyoung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a357t-df86bbfd432caba230cefe11607f0d9133194441eba8439a59fd5dfca396846a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Lung - diagnostic imaging</topic><topic>Metal Nanoparticles</topic><topic>Porosity</topic><topic>Rabbits</topic><topic>Silicon</topic><topic>Silver</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed</topic><toplevel>online_resources</toplevel><creatorcontrib>Lee, Eun Mi</creatorcontrib><creatorcontrib>Lee, Jiyeon</creatorcontrib><creatorcontrib>Kim, Yejin</creatorcontrib><creatorcontrib>Yi, Kyung Sik</creatorcontrib><creatorcontrib>Cho, Janggeun</creatorcontrib><creatorcontrib>Kim, Jaehoon</creatorcontrib><creatorcontrib>An, Jong Min</creatorcontrib><creatorcontrib>Lee, Dahae</creatorcontrib><creatorcontrib>Kim, Sung Joon</creatorcontrib><creatorcontrib>An, Eunkyung</creatorcontrib><creatorcontrib>Hong, Yoo Jin</creatorcontrib><creatorcontrib>Jo, Hyejung</creatorcontrib><creatorcontrib>Lee, Seo Hyeon</creatorcontrib><creatorcontrib>Jung, Yuna</creatorcontrib><creatorcontrib>Choi, Chi-Hoon</creatorcontrib><creatorcontrib>Kang, Jae Seung</creatorcontrib><creatorcontrib>Hur, Jin</creatorcontrib><creatorcontrib>Kim, Dokyoung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS biomaterials science & engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Eun Mi</au><au>Lee, Jiyeon</au><au>Kim, Yejin</au><au>Yi, Kyung Sik</au><au>Cho, Janggeun</au><au>Kim, Jaehoon</au><au>An, Jong Min</au><au>Lee, Dahae</au><au>Kim, Sung Joon</au><au>An, Eunkyung</au><au>Hong, Yoo Jin</au><au>Jo, Hyejung</au><au>Lee, Seo Hyeon</au><au>Jung, Yuna</au><au>Choi, Chi-Hoon</au><au>Kang, Jae Seung</au><au>Hur, Jin</au><au>Kim, Dokyoung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hybrid Composite of Silver Nanoparticle–Porous Silicon Microparticles as an Image-Guided Localization Agent for Computed Tomography Scan of the Lungs</atitle><jtitle>ACS biomaterials science & engineering</jtitle><addtitle>ACS Biomater. Sci. Eng</addtitle><date>2020-08-10</date><risdate>2020</risdate><volume>6</volume><issue>8</issue><spage>4390</spage><epage>4396</epage><pages>4390-4396</pages><issn>2373-9878</issn><eissn>2373-9878</eissn><abstract>A hybrid composite of silver nanoparticles (AgNPs) and porous silicon microparticles (pSiMPs) was developed and applied for the computed tomography (CT) scanning of the lungs as an image-guided localization agent. We confirmed the grafting of AgNPs on oxidized pSiMPs template using various analytical equipment, including a scanning electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDS). The hybrid composite showed a high CT contrast intensity (>1000 HU) that enabled us to produce and view images of the lungs. In addition, it showed the ability to maintain a strong CT signal at the injected area of the rabbit’s lungs, up to an hour, without spreading. 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| subjects | Animals Lung - diagnostic imaging Metal Nanoparticles Porosity Rabbits Silicon Silver Tomography Tomography, X-Ray Computed |
| title | Hybrid Composite of Silver Nanoparticle–Porous Silicon Microparticles as an Image-Guided Localization Agent for Computed Tomography Scan of the Lungs |
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