Visualizing, quantifying, and manipulating mitochondrial DNA in vivo

Mitochondrial DNA (mtDNA) encodes proteins and RNAs that support the functions of mitochondria and thereby numerous physiological processes. Mutations of mtDNA can cause mitochondrial diseases and are implicated in aging. The mtDNA within cells is organized into nucleoids within the mitochondrial ma...

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Veröffentlicht in:	The Journal of biological chemistry 2020-12, Vol.295 (51), p.17588-17601
Hauptverfasser:	Prole, David L., Chinnery, Patrick F., Jones, Nick S.
Format:	Artikel
Sprache:	eng
Schlagworte:	aging gene editing microscopy mitochondria mitochondrial disease mitochondrial DNA (mtDNA) mitophagy
Online-Zugang:	Volltext
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