Polymerase γ efficiently replicates through many natural template barriers but stalls at the HSP1 quadruplex

Faithful replication of the mitochondrial genome is carried out by a set of key nuclear-encoded proteins. DNA polymerase γ is a core component of the mtDNA replisome and the only replicative DNA polymerase localized to mitochondria. The asynchronous mechanism of mtDNA replication predicts that the r...

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Veröffentlicht in:	The Journal of biological chemistry 2020-12, Vol.295 (51), p.17802-17815
Hauptverfasser:	Sullivan, Eric D., Longley, Matthew J., Copeland, William C.
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA polymerase γ DNA replication DNA structure G-quadruplex heavy-strand promoter mitochondrial DNA (mtDNA) mitochondrial DNA damage mtDNA deletion
Online-Zugang:	Volltext
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