Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia

Positive modulation of cAMP signalling by phosphodiesterase (PDE) inhibitors has recently been explored as a potential target for the reversal of cognitive and behavioural deficits implicating the corticoaccumbal circuit. Previous studies show that PDE type 1 isoform B (PDE1B) inhibition may improve...

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Veröffentlicht in:	Neuropharmacology 2021-03, Vol.186, p.108454-108454, Article 108454
Hauptverfasser:	Hayes, Jessica, Laursen, Bettina, Eneberg, Elin, Kehler, Jan, Rasmussen, Lars Kyhn, Langgard, Morten, Bastlund, Jesper F., Gerdjikov, Todor V.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-CSRTT Medial prefrontal cortex Nucleus accumbens Phencyclidine Phosphodiesterase type 1 (PDE1)
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