Association of Blood Pressure With the Progression of CKD: Findings From KNOW-CKD Study

Optimal blood pressure (BP) control is a major therapeutic strategy in the management of chronic kidney disease (CKD). We studied the association between BP and adverse kidney outcomes within a diverse cohort of Koreans with CKD. Prospective observational cohort study. 2,044 participants from the Korean Cohort Study for Outcomes in Patients With CKD (KNOW-CKD). Baseline and time-updated systolic BP (SBP) and diastolic BP (DBP). A composite kidney outcome of a≥50% decline in estimated glomerular filtration rate (eGFR) from the baseline value or incident kidney replacement therapy. Multivariate cause-specific hazards models and marginal structural models were fitted for baseline and time-updated BP, respectively. During 7,472 person-years of follow-up, the primary composite kidney outcome occurred in 473 participants (23.1%), an incidence rate of 63.3 per 1,000 patient-years. Compared with baseline SBP