Classification of endplate lesions in the lumbar spine and association with risk factors, biochemistry, and genetics
Purpose To detect the associations between the degree of the endplate (EP) lesions with the presence of risk factors, biochemical and genetic markers previously observed in low back pain (LBP) patients with EP defects in comparison with hernia/discopathy patients and healthy controls. Methods In thi...
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| Veröffentlicht in: | European spine journal 2021-08, Vol.30 (8), p.2231-2237 |
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| container_title | European spine journal |
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| creator | Colombini, Alessandra Galbusera, Fabio Cortese, Maria Cristina Gallazzi, Enrico Viganò, Marco Albano, Domenico Cauci, Sabina Sconfienza, Luca Maria Brayda-Bruno, Marco |
| description | Purpose
To detect the associations between the degree of the endplate (EP) lesions with the presence of risk factors, biochemical and genetic markers previously observed in low back pain (LBP) patients with EP defects in comparison with hernia/discopathy patients and healthy controls.
Methods
In this observational retrospective study, T2-weighted sagittal MRI images (
n
= 223 LBP patients) were scored for EP lesions by two independent observers. Total MRI score and number of affected levels (L1/L2–L5/S1) have been considered for the correlation with demographic, behavioral, clinical, biochemical (25(OH)D, CTx-I and CTx-II levels,
n
= 69 males) and
VDR
variables.
Results
Males showed higher BMI and total MRI score than females. Patients bearing
TT
compared to
tt VDR
genotypes showed significant higher total MRI scores. Among males (
n
= 125),
TT
,
bb
and
aa
genotypes showed increased total MRI scores. Higher total MRI score directly correlates with higher levels of CTx-I and CTx-II (
n
= 69 males).
Conclusions
The markers previously identified as associated with the presence of EP lesions have been confirmed as related to their severity and could be used to follow the pathology progression. |
| doi_str_mv | 10.1007/s00586-021-06719-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2478595330</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2560163112</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-4a291fc10890bd43b4d20b1e71bed8f680bbd789df3da1b0095e68833b6e384b3</originalsourceid><addsrcrecordid>eNp9kU1rFTEUhoMo9lr9Ay4k4MZFR0-SmUyylItfUHCj65CPM72pcyfXJEPpvzftVAUXrkJynufNgZeQlwzeMoDxXQEYlOyAsw7kyHTHHpEd6wXvQAv-mOxA99DdTc7Is1KuAdigQT4lZ0L0A9dc7kjdz7aUOEVva0wLTRPFJZxmW5HOWNpToXGh9dCu69HZTMspLkjtEmgTk4-bdxPrgeZYftDJ-ppyuaAuJn_AYyw1317cC1e4YI2-PCdPJjsXfPFwnpPvHz9823_uLr9--rJ_f9l5MQ616y3XbPIMlAYXeuH6wMExHJnDoCapwLkwKh0mESxzAHpAqZQQTqJQvRPn5M2We8rp54qlmraNx3m2C6a1GN6PatCDENDQ1_-g12nNS9vO8EECk4Ix3ii-UT6nUjJO5pTj0eZbw8DcdWK2TkzrxNx3YliTXj1Er-6I4Y_yu4QGiA0obbRcYf77939ifwHOOZgB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2560163112</pqid></control><display><type>article</type><title>Classification of endplate lesions in the lumbar spine and association with risk factors, biochemistry, and genetics</title><source>SpringerNature Journals</source><creator>Colombini, Alessandra ; Galbusera, Fabio ; Cortese, Maria Cristina ; Gallazzi, Enrico ; Viganò, Marco ; Albano, Domenico ; Cauci, Sabina ; Sconfienza, Luca Maria ; Brayda-Bruno, Marco</creator><creatorcontrib>Colombini, Alessandra ; Galbusera, Fabio ; Cortese, Maria Cristina ; Gallazzi, Enrico ; Viganò, Marco ; Albano, Domenico ; Cauci, Sabina ; Sconfienza, Luca Maria ; Brayda-Bruno, Marco</creatorcontrib><description>Purpose
To detect the associations between the degree of the endplate (EP) lesions with the presence of risk factors, biochemical and genetic markers previously observed in low back pain (LBP) patients with EP defects in comparison with hernia/discopathy patients and healthy controls.
Methods
In this observational retrospective study, T2-weighted sagittal MRI images (
n
= 223 LBP patients) were scored for EP lesions by two independent observers. Total MRI score and number of affected levels (L1/L2–L5/S1) have been considered for the correlation with demographic, behavioral, clinical, biochemical (25(OH)D, CTx-I and CTx-II levels,
n
= 69 males) and
VDR
variables.
Results
Males showed higher BMI and total MRI score than females. Patients bearing
TT
compared to
tt VDR
genotypes showed significant higher total MRI scores. Among males (
n
= 125),
TT
,
bb
and
aa
genotypes showed increased total MRI scores. Higher total MRI score directly correlates with higher levels of CTx-I and CTx-II (
n
= 69 males).
Conclusions
The markers previously identified as associated with the presence of EP lesions have been confirmed as related to their severity and could be used to follow the pathology progression.</description><identifier>ISSN: 0940-6719</identifier><identifier>EISSN: 1432-0932</identifier><identifier>DOI: 10.1007/s00586-021-06719-1</identifier><identifier>PMID: 33452926</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>25-Hydroxyvitamin D ; Arthritis ; Back pain ; Back surgery ; Biochemistry ; Body mass index ; Genetic markers ; Genotypes ; Hernia ; Lesions ; Low back pain ; Magnetic resonance imaging ; Males ; Medicine ; Medicine & Public Health ; Neurosurgery ; Original Article ; Pathology ; Patients ; Population ; Risk factors ; Scoliosis ; Spine (lumbar) ; Surgical Orthopedics ; Vertebrae ; Vitamin D</subject><ispartof>European spine journal, 2021-08, Vol.30 (8), p.2231-2237</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4a291fc10890bd43b4d20b1e71bed8f680bbd789df3da1b0095e68833b6e384b3</citedby><cites>FETCH-LOGICAL-c375t-4a291fc10890bd43b4d20b1e71bed8f680bbd789df3da1b0095e68833b6e384b3</cites><orcidid>0000-0002-1800-3424</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00586-021-06719-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00586-021-06719-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33452926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colombini, Alessandra</creatorcontrib><creatorcontrib>Galbusera, Fabio</creatorcontrib><creatorcontrib>Cortese, Maria Cristina</creatorcontrib><creatorcontrib>Gallazzi, Enrico</creatorcontrib><creatorcontrib>Viganò, Marco</creatorcontrib><creatorcontrib>Albano, Domenico</creatorcontrib><creatorcontrib>Cauci, Sabina</creatorcontrib><creatorcontrib>Sconfienza, Luca Maria</creatorcontrib><creatorcontrib>Brayda-Bruno, Marco</creatorcontrib><title>Classification of endplate lesions in the lumbar spine and association with risk factors, biochemistry, and genetics</title><title>European spine journal</title><addtitle>Eur Spine J</addtitle><addtitle>Eur Spine J</addtitle><description>Purpose
To detect the associations between the degree of the endplate (EP) lesions with the presence of risk factors, biochemical and genetic markers previously observed in low back pain (LBP) patients with EP defects in comparison with hernia/discopathy patients and healthy controls.
Methods
In this observational retrospective study, T2-weighted sagittal MRI images (
n
= 223 LBP patients) were scored for EP lesions by two independent observers. Total MRI score and number of affected levels (L1/L2–L5/S1) have been considered for the correlation with demographic, behavioral, clinical, biochemical (25(OH)D, CTx-I and CTx-II levels,
n
= 69 males) and
VDR
variables.
Results
Males showed higher BMI and total MRI score than females. Patients bearing
TT
compared to
tt VDR
genotypes showed significant higher total MRI scores. Among males (
n
= 125),
TT
,
bb
and
aa
genotypes showed increased total MRI scores. Higher total MRI score directly correlates with higher levels of CTx-I and CTx-II (
n
= 69 males).
Conclusions
The markers previously identified as associated with the presence of EP lesions have been confirmed as related to their severity and could be used to follow the pathology progression.</description><subject>25-Hydroxyvitamin D</subject><subject>Arthritis</subject><subject>Back pain</subject><subject>Back surgery</subject><subject>Biochemistry</subject><subject>Body mass index</subject><subject>Genetic markers</subject><subject>Genotypes</subject><subject>Hernia</subject><subject>Lesions</subject><subject>Low back pain</subject><subject>Magnetic resonance imaging</subject><subject>Males</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Patients</subject><subject>Population</subject><subject>Risk factors</subject><subject>Scoliosis</subject><subject>Spine (lumbar)</subject><subject>Surgical Orthopedics</subject><subject>Vertebrae</subject><subject>Vitamin D</subject><issn>0940-6719</issn><issn>1432-0932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1rFTEUhoMo9lr9Ay4k4MZFR0-SmUyylItfUHCj65CPM72pcyfXJEPpvzftVAUXrkJynufNgZeQlwzeMoDxXQEYlOyAsw7kyHTHHpEd6wXvQAv-mOxA99DdTc7Is1KuAdigQT4lZ0L0A9dc7kjdz7aUOEVva0wLTRPFJZxmW5HOWNpToXGh9dCu69HZTMspLkjtEmgTk4-bdxPrgeZYftDJ-ppyuaAuJn_AYyw1317cC1e4YI2-PCdPJjsXfPFwnpPvHz9823_uLr9--rJ_f9l5MQ616y3XbPIMlAYXeuH6wMExHJnDoCapwLkwKh0mESxzAHpAqZQQTqJQvRPn5M2We8rp54qlmraNx3m2C6a1GN6PatCDENDQ1_-g12nNS9vO8EECk4Ix3ii-UT6nUjJO5pTj0eZbw8DcdWK2TkzrxNx3YliTXj1Er-6I4Y_yu4QGiA0obbRcYf77939ifwHOOZgB</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Colombini, Alessandra</creator><creator>Galbusera, Fabio</creator><creator>Cortese, Maria Cristina</creator><creator>Gallazzi, Enrico</creator><creator>Viganò, Marco</creator><creator>Albano, Domenico</creator><creator>Cauci, Sabina</creator><creator>Sconfienza, Luca Maria</creator><creator>Brayda-Bruno, Marco</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1800-3424</orcidid></search><sort><creationdate>20210801</creationdate><title>Classification of endplate lesions in the lumbar spine and association with risk factors, biochemistry, and genetics</title><author>Colombini, Alessandra ; Galbusera, Fabio ; Cortese, Maria Cristina ; Gallazzi, Enrico ; Viganò, Marco ; Albano, Domenico ; Cauci, Sabina ; Sconfienza, Luca Maria ; Brayda-Bruno, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-4a291fc10890bd43b4d20b1e71bed8f680bbd789df3da1b0095e68833b6e384b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Arthritis</topic><topic>Back pain</topic><topic>Back surgery</topic><topic>Biochemistry</topic><topic>Body mass index</topic><topic>Genetic markers</topic><topic>Genotypes</topic><topic>Hernia</topic><topic>Lesions</topic><topic>Low back pain</topic><topic>Magnetic resonance imaging</topic><topic>Males</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Pathology</topic><topic>Patients</topic><topic>Population</topic><topic>Risk factors</topic><topic>Scoliosis</topic><topic>Spine (lumbar)</topic><topic>Surgical Orthopedics</topic><topic>Vertebrae</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colombini, Alessandra</creatorcontrib><creatorcontrib>Galbusera, Fabio</creatorcontrib><creatorcontrib>Cortese, Maria Cristina</creatorcontrib><creatorcontrib>Gallazzi, Enrico</creatorcontrib><creatorcontrib>Viganò, Marco</creatorcontrib><creatorcontrib>Albano, Domenico</creatorcontrib><creatorcontrib>Cauci, Sabina</creatorcontrib><creatorcontrib>Sconfienza, Luca Maria</creatorcontrib><creatorcontrib>Brayda-Bruno, Marco</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European spine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colombini, Alessandra</au><au>Galbusera, Fabio</au><au>Cortese, Maria Cristina</au><au>Gallazzi, Enrico</au><au>Viganò, Marco</au><au>Albano, Domenico</au><au>Cauci, Sabina</au><au>Sconfienza, Luca Maria</au><au>Brayda-Bruno, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Classification of endplate lesions in the lumbar spine and association with risk factors, biochemistry, and genetics</atitle><jtitle>European spine journal</jtitle><stitle>Eur Spine J</stitle><addtitle>Eur Spine J</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>30</volume><issue>8</issue><spage>2231</spage><epage>2237</epage><pages>2231-2237</pages><issn>0940-6719</issn><eissn>1432-0932</eissn><abstract>Purpose
To detect the associations between the degree of the endplate (EP) lesions with the presence of risk factors, biochemical and genetic markers previously observed in low back pain (LBP) patients with EP defects in comparison with hernia/discopathy patients and healthy controls.
Methods
In this observational retrospective study, T2-weighted sagittal MRI images (
n
= 223 LBP patients) were scored for EP lesions by two independent observers. Total MRI score and number of affected levels (L1/L2–L5/S1) have been considered for the correlation with demographic, behavioral, clinical, biochemical (25(OH)D, CTx-I and CTx-II levels,
n
= 69 males) and
VDR
variables.
Results
Males showed higher BMI and total MRI score than females. Patients bearing
TT
compared to
tt VDR
genotypes showed significant higher total MRI scores. Among males (
n
= 125),
TT
,
bb
and
aa
genotypes showed increased total MRI scores. Higher total MRI score directly correlates with higher levels of CTx-I and CTx-II (
n
= 69 males).
Conclusions
The markers previously identified as associated with the presence of EP lesions have been confirmed as related to their severity and could be used to follow the pathology progression.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33452926</pmid><doi>10.1007/s00586-021-06719-1</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1800-3424</orcidid></addata></record> |
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| ispartof | European spine journal, 2021-08, Vol.30 (8), p.2231-2237 |
| issn | 0940-6719 1432-0932 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2478595330 |
| source | SpringerNature Journals |
| subjects | 25-Hydroxyvitamin D Arthritis Back pain Back surgery Biochemistry Body mass index Genetic markers Genotypes Hernia Lesions Low back pain Magnetic resonance imaging Males Medicine Medicine & Public Health Neurosurgery Original Article Pathology Patients Population Risk factors Scoliosis Spine (lumbar) Surgical Orthopedics Vertebrae Vitamin D |
| title | Classification of endplate lesions in the lumbar spine and association with risk factors, biochemistry, and genetics |
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