Prediction of 10-year mortality using hs-CRP in Chinese people with hyperglycemia: Findings from the Da Qing diabetes prevention outcomes study
•CRP levels vary across ethnicities.•The association of CRP with mortality remains unclear in East Asians with T2DM.•hs-CRP predicted 10-year all-cause death in Chinese adults with hyperglycaemia.•The impact of low-grade inflammation on death in T2DM people should not be ignored. To examine whether...
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| Veröffentlicht in: | Diabetes research and clinical practice 2021-03, Vol.173, p.108668-108668, Article 108668 |
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| container_title | Diabetes research and clinical practice |
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| creator | Qian, Xin He, Siyao Wang, Jinping Gong, Qiuhong An, Yali Li, Hui Chen, Yanyan Li, Guangwei |
| description | •CRP levels vary across ethnicities.•The association of CRP with mortality remains unclear in East Asians with T2DM.•hs-CRP predicted 10-year all-cause death in Chinese adults with hyperglycaemia.•The impact of low-grade inflammation on death in T2DM people should not be ignored.
To examine whether high-sensitivity C-reactive protein (hs-CRP) can predict all-cause death in Chinese adults with hyperglycemia.
All the 237 diabetes and 49 prediabetes recruited in the study were evolved from the participants with impaired glucose tolerance in the original Da Qing Diabetes Study. Blood hs-CRP level was measured at 2006. Ten-year outcome of death was traced from 2006 to 2016. Cox model was used to analyse the association between hs-CRP level and the risk of all-cause death occurred over the subsequent 10 years.
During the follow-up, death occurred in 36 (37.9%) subjects in the highest hs-CRP tertile group (hs-CRP > 2.16 mg/L) and 19 (20.0%) in the lowest hs-CRP tertile group (hs-CRP |
| doi_str_mv | 10.1016/j.diabres.2021.108668 |
| format | Article |
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To examine whether high-sensitivity C-reactive protein (hs-CRP) can predict all-cause death in Chinese adults with hyperglycemia.
All the 237 diabetes and 49 prediabetes recruited in the study were evolved from the participants with impaired glucose tolerance in the original Da Qing Diabetes Study. Blood hs-CRP level was measured at 2006. Ten-year outcome of death was traced from 2006 to 2016. Cox model was used to analyse the association between hs-CRP level and the risk of all-cause death occurred over the subsequent 10 years.
During the follow-up, death occurred in 36 (37.9%) subjects in the highest hs-CRP tertile group (hs-CRP > 2.16 mg/L) and 19 (20.0%) in the lowest hs-CRP tertile group (hs-CRP < 0.82 mg/L, p < 0.05). The corresponding incidence of all-cause death (per 1,000 person-years) was 44.7 (95% CI 30.1–59.3) and 21.6 (95% CI 11.9–31.3) in the two groups respectively (p < 0.0001). The highest hs-CRP tertile was associated with the increased risk of all-cause death significantly (hazard ratio 1.88, 95% CI 1.07–3.32) after controlling for traditional risk factors.
Serum hs-CRP was predictive of 10-year all-cause death in Chinese adults with hyperglycemia, suggesting the impact of low-grade inflammation on mortality deserves more attention.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2021.108668</identifier><identifier>PMID: 33453295</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Aged ; All-cause mortality ; C-Reactive Protein - metabolism ; China ; Diabetes Mellitus - blood ; Diabetes Mellitus - mortality ; Diabetes Mellitus - prevention & control ; Female ; hs-CRP ; Humans ; Hyperglycemia ; Hyperglycemia - diagnosis ; Incidence ; Male ; Middle Aged ; Mortality ; Risk Factors ; Time Factors</subject><ispartof>Diabetes research and clinical practice, 2021-03, Vol.173, p.108668-108668, Article 108668</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3169-4b9377b4f5f832bb82c37d96470ce38171166e5a3bb4ee2626b315fb4c7b96433</citedby><cites>FETCH-LOGICAL-c3169-4b9377b4f5f832bb82c37d96470ce38171166e5a3bb4ee2626b315fb4c7b96433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168822721000218$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33453295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qian, Xin</creatorcontrib><creatorcontrib>He, Siyao</creatorcontrib><creatorcontrib>Wang, Jinping</creatorcontrib><creatorcontrib>Gong, Qiuhong</creatorcontrib><creatorcontrib>An, Yali</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Chen, Yanyan</creatorcontrib><creatorcontrib>Li, Guangwei</creatorcontrib><title>Prediction of 10-year mortality using hs-CRP in Chinese people with hyperglycemia: Findings from the Da Qing diabetes prevention outcomes study</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>•CRP levels vary across ethnicities.•The association of CRP with mortality remains unclear in East Asians with T2DM.•hs-CRP predicted 10-year all-cause death in Chinese adults with hyperglycaemia.•The impact of low-grade inflammation on death in T2DM people should not be ignored.
To examine whether high-sensitivity C-reactive protein (hs-CRP) can predict all-cause death in Chinese adults with hyperglycemia.
All the 237 diabetes and 49 prediabetes recruited in the study were evolved from the participants with impaired glucose tolerance in the original Da Qing Diabetes Study. Blood hs-CRP level was measured at 2006. Ten-year outcome of death was traced from 2006 to 2016. Cox model was used to analyse the association between hs-CRP level and the risk of all-cause death occurred over the subsequent 10 years.
During the follow-up, death occurred in 36 (37.9%) subjects in the highest hs-CRP tertile group (hs-CRP > 2.16 mg/L) and 19 (20.0%) in the lowest hs-CRP tertile group (hs-CRP < 0.82 mg/L, p < 0.05). The corresponding incidence of all-cause death (per 1,000 person-years) was 44.7 (95% CI 30.1–59.3) and 21.6 (95% CI 11.9–31.3) in the two groups respectively (p < 0.0001). The highest hs-CRP tertile was associated with the increased risk of all-cause death significantly (hazard ratio 1.88, 95% CI 1.07–3.32) after controlling for traditional risk factors.
Serum hs-CRP was predictive of 10-year all-cause death in Chinese adults with hyperglycemia, suggesting the impact of low-grade inflammation on mortality deserves more attention.</description><subject>Adult</subject><subject>Aged</subject><subject>All-cause mortality</subject><subject>C-Reactive Protein - metabolism</subject><subject>China</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - mortality</subject><subject>Diabetes Mellitus - prevention & control</subject><subject>Female</subject><subject>hs-CRP</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - diagnosis</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Risk Factors</subject><subject>Time Factors</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi0EotvCI4B85JLFfxLbywWhhRakSrQVnK3YmTReJXGwnaI8Ba-Mlyy99jSj0e-bz54PoTeUbCmh4v1h27jaBIhbRhjNMyWEeoY2VElWKMbkc7TJnPrXn6HzGA-EEMHL6iU647lwtqs26M9NgMbZ5PyIfYspKRaoAx58SHXv0oLn6MZ73MVif3eD3Yj3nRshAp7ATz3g3y51uFsmCPf9YmFw9Qd86cYmiyJugx9w6gB_rvHtcc3xyZAg4inAA4yr65ysH_IsprlZXqEXbd1HeH2qF-jn5Zcf-6_F9ferb_tP14XlVOyK0uy4lKZsq1ZxZoxilstmJ0pJLHBFJaVCQFVzY0oAJpgwnFatKa00meL8Ar1b907B_5ohJj24aKHv6xH8HDUrpapURUuZ0WpFbfAxBmj1FNxQh0VToo9Z6IM-ZaGPWeg1i6x7e7KYzQDNo-r_8TPwcQUgf_TBQdDROhhtDiSATbrx7gmLvyqrnjc</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Qian, Xin</creator><creator>He, Siyao</creator><creator>Wang, Jinping</creator><creator>Gong, Qiuhong</creator><creator>An, Yali</creator><creator>Li, Hui</creator><creator>Chen, Yanyan</creator><creator>Li, Guangwei</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210301</creationdate><title>Prediction of 10-year mortality using hs-CRP in Chinese people with hyperglycemia: Findings from the Da Qing diabetes prevention outcomes study</title><author>Qian, Xin ; He, Siyao ; Wang, Jinping ; Gong, Qiuhong ; An, Yali ; Li, Hui ; Chen, Yanyan ; Li, Guangwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3169-4b9377b4f5f832bb82c37d96470ce38171166e5a3bb4ee2626b315fb4c7b96433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>All-cause mortality</topic><topic>C-Reactive Protein - metabolism</topic><topic>China</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - mortality</topic><topic>Diabetes Mellitus - prevention & control</topic><topic>Female</topic><topic>hs-CRP</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - diagnosis</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Risk Factors</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qian, Xin</creatorcontrib><creatorcontrib>He, Siyao</creatorcontrib><creatorcontrib>Wang, Jinping</creatorcontrib><creatorcontrib>Gong, Qiuhong</creatorcontrib><creatorcontrib>An, Yali</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Chen, Yanyan</creatorcontrib><creatorcontrib>Li, Guangwei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qian, Xin</au><au>He, Siyao</au><au>Wang, Jinping</au><au>Gong, Qiuhong</au><au>An, Yali</au><au>Li, Hui</au><au>Chen, Yanyan</au><au>Li, Guangwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of 10-year mortality using hs-CRP in Chinese people with hyperglycemia: Findings from the Da Qing diabetes prevention outcomes study</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>173</volume><spage>108668</spage><epage>108668</epage><pages>108668-108668</pages><artnum>108668</artnum><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>•CRP levels vary across ethnicities.•The association of CRP with mortality remains unclear in East Asians with T2DM.•hs-CRP predicted 10-year all-cause death in Chinese adults with hyperglycaemia.•The impact of low-grade inflammation on death in T2DM people should not be ignored.
To examine whether high-sensitivity C-reactive protein (hs-CRP) can predict all-cause death in Chinese adults with hyperglycemia.
All the 237 diabetes and 49 prediabetes recruited in the study were evolved from the participants with impaired glucose tolerance in the original Da Qing Diabetes Study. Blood hs-CRP level was measured at 2006. Ten-year outcome of death was traced from 2006 to 2016. Cox model was used to analyse the association between hs-CRP level and the risk of all-cause death occurred over the subsequent 10 years.
During the follow-up, death occurred in 36 (37.9%) subjects in the highest hs-CRP tertile group (hs-CRP > 2.16 mg/L) and 19 (20.0%) in the lowest hs-CRP tertile group (hs-CRP < 0.82 mg/L, p < 0.05). The corresponding incidence of all-cause death (per 1,000 person-years) was 44.7 (95% CI 30.1–59.3) and 21.6 (95% CI 11.9–31.3) in the two groups respectively (p < 0.0001). The highest hs-CRP tertile was associated with the increased risk of all-cause death significantly (hazard ratio 1.88, 95% CI 1.07–3.32) after controlling for traditional risk factors.
Serum hs-CRP was predictive of 10-year all-cause death in Chinese adults with hyperglycemia, suggesting the impact of low-grade inflammation on mortality deserves more attention.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>33453295</pmid><doi>10.1016/j.diabres.2021.108668</doi><tpages>1</tpages></addata></record> |
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| subjects | Adult Aged All-cause mortality C-Reactive Protein - metabolism China Diabetes Mellitus - blood Diabetes Mellitus - mortality Diabetes Mellitus - prevention & control Female hs-CRP Humans Hyperglycemia Hyperglycemia - diagnosis Incidence Male Middle Aged Mortality Risk Factors Time Factors |
| title | Prediction of 10-year mortality using hs-CRP in Chinese people with hyperglycemia: Findings from the Da Qing diabetes prevention outcomes study |
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