Biodegradable Zn−3Mg−0.7Mg2Si composite fabricated by high-pressure solidification for bone implant applications
Zinc (Zn)-based alloys have been considered potential biodegradable materials for medical applications due to their good biodegradability and biocompatibility. However, the insufficient mechanical properties of pure Zn do not meet the requirements of biodegradable implants. In this study, we have de...
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| Veröffentlicht in: | Acta biomaterialia 2021-03, Vol.123, p.407-417 |
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| creator | Tong, Xian Cai, Wenhao Lin, Jixing Wang, Kun Jin, Lufan Shi, Zimu Zhang, Dechuang Lin, Jianguo Li, Yuncang Dargusch, Matthew Wen, Cuie |
| description | Zinc (Zn)-based alloys have been considered potential biodegradable materials for medical applications due to their good biodegradability and biocompatibility. However, the insufficient mechanical properties of pure Zn do not meet the requirements of biodegradable implants. In this study, we have developed a biodegradable Zn−3Mg−0.7Mg2Si composite fabricated by high-pressure solidification. Microstructural characterization revealed that the high-pressure solidified (HPS) composite exhibited uniformly distributed fine MgZn2 granules in an α-Zn matrix. Comprehensive tests indicated that the HPS composite exhibited exceptionally high compression properties including a compressive yield strength of 406.2 MPa, an ultimate compressive strength of 1181.2 MPa, and plastic deformation up to 60% strain without cracking or fracturing. Potentiodynamic polarization tests revealed that the HPS composite showed a corrosion potential of −0.930 V, a corrosion current density of 3.5 μA/cm2, and a corrosion rate of 46.2 μm/y. Immersion tests revealed that the degradation rate of the HPS composite after immersion in Hanks’ solution for 1 month and 3 months was 42.8 μm/y and 37.8 μm/y, respectively. Furthermore, an extract of the HPS composite exhibited good cytocompatibility compared with as-cast (AC) pure Zn and an AC composite at a concentration of ≤25%. These results suggest that the HPS Zn−3Mg−0.7Mg2Si composite can be anticipated as a promising biodegradable material for orthopedic applications.
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| doi_str_mv | 10.1016/j.actbio.2020.12.059 |
| format | Article |
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[Display omitted]</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2020.12.059</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Biocompatibility ; Biodegradability ; Biodegradable materials ; Biodegradable metal ; Biodegradation ; Compression ; Compression tests ; Compressive properties ; Compressive strength ; Corrosion ; Corrosion currents ; Corrosion potential ; Corrosion rate ; Cracking (fracturing) ; Friction and wear ; High-pressure solidification ; Immersion ; Immersion tests (corrosion) ; In vitro biocompatibility ; Mechanical properties ; Medical materials ; Orthopedics ; Plastic deformation ; Pressure ; Solidification ; Stress concentration ; Surgical implants ; Transplants & implants ; Zinc ; Zn-based composite</subject><ispartof>Acta biomaterialia, 2021-03, Vol.123, p.407-417</ispartof><rights>2021</rights><rights>Copyright Elsevier BV Mar 15, 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-22c4f88efdf961e3758be93c1b43d367f7109c41055b03e4d6c96b5b62b385803</citedby><cites>FETCH-LOGICAL-c367t-22c4f88efdf961e3758be93c1b43d367f7109c41055b03e4d6c96b5b62b385803</cites><orcidid>0000-0002-3626-3238 ; 0000-0001-8008-3536 ; 0000-0003-4336-5811</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.actbio.2020.12.059$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids></links><search><creatorcontrib>Tong, Xian</creatorcontrib><creatorcontrib>Cai, Wenhao</creatorcontrib><creatorcontrib>Lin, Jixing</creatorcontrib><creatorcontrib>Wang, Kun</creatorcontrib><creatorcontrib>Jin, Lufan</creatorcontrib><creatorcontrib>Shi, Zimu</creatorcontrib><creatorcontrib>Zhang, Dechuang</creatorcontrib><creatorcontrib>Lin, Jianguo</creatorcontrib><creatorcontrib>Li, Yuncang</creatorcontrib><creatorcontrib>Dargusch, Matthew</creatorcontrib><creatorcontrib>Wen, Cuie</creatorcontrib><title>Biodegradable Zn−3Mg−0.7Mg2Si composite fabricated by high-pressure solidification for bone implant applications</title><title>Acta biomaterialia</title><description>Zinc (Zn)-based alloys have been considered potential biodegradable materials for medical applications due to their good biodegradability and biocompatibility. However, the insufficient mechanical properties of pure Zn do not meet the requirements of biodegradable implants. In this study, we have developed a biodegradable Zn−3Mg−0.7Mg2Si composite fabricated by high-pressure solidification. Microstructural characterization revealed that the high-pressure solidified (HPS) composite exhibited uniformly distributed fine MgZn2 granules in an α-Zn matrix. Comprehensive tests indicated that the HPS composite exhibited exceptionally high compression properties including a compressive yield strength of 406.2 MPa, an ultimate compressive strength of 1181.2 MPa, and plastic deformation up to 60% strain without cracking or fracturing. Potentiodynamic polarization tests revealed that the HPS composite showed a corrosion potential of −0.930 V, a corrosion current density of 3.5 μA/cm2, and a corrosion rate of 46.2 μm/y. Immersion tests revealed that the degradation rate of the HPS composite after immersion in Hanks’ solution for 1 month and 3 months was 42.8 μm/y and 37.8 μm/y, respectively. Furthermore, an extract of the HPS composite exhibited good cytocompatibility compared with as-cast (AC) pure Zn and an AC composite at a concentration of ≤25%. These results suggest that the HPS Zn−3Mg−0.7Mg2Si composite can be anticipated as a promising biodegradable material for orthopedic applications.
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However, the insufficient mechanical properties of pure Zn do not meet the requirements of biodegradable implants. In this study, we have developed a biodegradable Zn−3Mg−0.7Mg2Si composite fabricated by high-pressure solidification. Microstructural characterization revealed that the high-pressure solidified (HPS) composite exhibited uniformly distributed fine MgZn2 granules in an α-Zn matrix. Comprehensive tests indicated that the HPS composite exhibited exceptionally high compression properties including a compressive yield strength of 406.2 MPa, an ultimate compressive strength of 1181.2 MPa, and plastic deformation up to 60% strain without cracking or fracturing. Potentiodynamic polarization tests revealed that the HPS composite showed a corrosion potential of −0.930 V, a corrosion current density of 3.5 μA/cm2, and a corrosion rate of 46.2 μm/y. Immersion tests revealed that the degradation rate of the HPS composite after immersion in Hanks’ solution for 1 month and 3 months was 42.8 μm/y and 37.8 μm/y, respectively. Furthermore, an extract of the HPS composite exhibited good cytocompatibility compared with as-cast (AC) pure Zn and an AC composite at a concentration of ≤25%. These results suggest that the HPS Zn−3Mg−0.7Mg2Si composite can be anticipated as a promising biodegradable material for orthopedic applications.
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| identifier | ISSN: 1742-7061 |
| ispartof | Acta biomaterialia, 2021-03, Vol.123, p.407-417 |
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| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Biocompatibility Biodegradability Biodegradable materials Biodegradable metal Biodegradation Compression Compression tests Compressive properties Compressive strength Corrosion Corrosion currents Corrosion potential Corrosion rate Cracking (fracturing) Friction and wear High-pressure solidification Immersion Immersion tests (corrosion) In vitro biocompatibility Mechanical properties Medical materials Orthopedics Plastic deformation Pressure Solidification Stress concentration Surgical implants Transplants & implants Zinc Zn-based composite |
| title | Biodegradable Zn−3Mg−0.7Mg2Si composite fabricated by high-pressure solidification for bone implant applications |
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