Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment
Objectives: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI). Methods: Hypertension, diabetes, dyslipidemia, and obesity were diagnosed based on self-report an...
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| Veröffentlicht in: | Dementia and Geriatric Cognitive Disorders Extra 2020-09, Vol.10 (3), p.154-162 |
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| creator | Vintimilla, Raul Balasubramanian, Kishore Hall, James Johnson, Leigh O’Bryant, Sid |
| description | Objectives: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI). Methods: Hypertension, diabetes, dyslipidemia, and obesity were diagnosed based on self-report and/or standardized procedures. Cognitive function was measured with MMSE, Logical Memory I and II, Trail A & B, FAS, animal naming, and digit span tests. Independent samples t tests and two-way ANOVAs were conducted for analyses, adjusting for relevant covariates. We studied 100 Mexican Americans (65 female) with MCI, ages 50–86, from a longitudinal study of cognitive aging conducted at the University of North Texas Health Science Center. Results: A difference between subjects with and without obesity and memory scores was shown by t tests. Two-way ANOVAs detected an association between the coexistence of hypertension and diabetes with language measures, diabetes and dyslipidemia with executive function, and diabetes and obesity with memory and language measures. Conclusions: This study provides additional evidence about the link between cardiovascular risk factors and cognitive dysfunction in MCI subjects, and also demonstrated that comorbid risk factors increased the degree of cognitive deficit in many areas, which may indicate a higher risk of developing dementia. |
| doi_str_mv | 10.1159/000511103 |
| format | Article |
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Methods: Hypertension, diabetes, dyslipidemia, and obesity were diagnosed based on self-report and/or standardized procedures. Cognitive function was measured with MMSE, Logical Memory I and II, Trail A & B, FAS, animal naming, and digit span tests. Independent samples t tests and two-way ANOVAs were conducted for analyses, adjusting for relevant covariates. We studied 100 Mexican Americans (65 female) with MCI, ages 50–86, from a longitudinal study of cognitive aging conducted at the University of North Texas Health Science Center. Results: A difference between subjects with and without obesity and memory scores was shown by t tests. Two-way ANOVAs detected an association between the coexistence of hypertension and diabetes with language measures, diabetes and dyslipidemia with executive function, and diabetes and obesity with memory and language measures. Conclusions: This study provides additional evidence about the link between cardiovascular risk factors and cognitive dysfunction in MCI subjects, and also demonstrated that comorbid risk factors increased the degree of cognitive deficit in many areas, which may indicate a higher risk of developing dementia.</description><identifier>ISSN: 1664-5464</identifier><identifier>EISSN: 1664-5464</identifier><identifier>DOI: 10.1159/000511103</identifier><identifier>PMID: 33442392</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Age ; Alzheimer's disease ; Between-subjects design ; Blood pressure ; Cardiovascular diseases ; cardiovascular risk factors ; Cholesterol ; Cognition & reasoning ; Cognition disorders ; Cognitive ability ; Dementia ; Demographics ; Diabetes ; Education ; Health aspects ; Hispanic Americans ; Hypertension ; Medical diagnosis ; Memory ; Metabolic disorders ; mexican american ; Mexican Americans ; mild cognitive impairment ; Neuropsychology ; Obesity ; Older people ; Psychological aspects ; Research Article ; Risk factors ; Statistics ; Triglycerides</subject><ispartof>Dementia and Geriatric Cognitive Disorders Extra, 2020-09, Vol.10 (3), p.154-162</ispartof><rights>2020 The Author(s) Published by S. Karger AG, Basel</rights><rights>Copyright © 2020 by S. Karger AG, Basel.</rights><rights>COPYRIGHT 2020 S. Karger AG</rights><rights>Copyright © 2020 by S. Karger AG, Basel 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-f4e626d4d43aa90ec114299cfe6e778055c3172c05caea0c58d7cc29ba8ca08c3</citedby><cites>FETCH-LOGICAL-c585t-f4e626d4d43aa90ec114299cfe6e778055c3172c05caea0c58d7cc29ba8ca08c3</cites><orcidid>0000-0002-4176-0001</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772868/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772868/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27612,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33442392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vintimilla, Raul</creatorcontrib><creatorcontrib>Balasubramanian, Kishore</creatorcontrib><creatorcontrib>Hall, James</creatorcontrib><creatorcontrib>Johnson, Leigh</creatorcontrib><creatorcontrib>O’Bryant, Sid</creatorcontrib><title>Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment</title><title>Dementia and Geriatric Cognitive Disorders Extra</title><addtitle>Dement Geriatr Cogn Disord Extra</addtitle><description>Objectives: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI). 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Dementia and Geriatric Cognitive Disorders Extra</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vintimilla, Raul</au><au>Balasubramanian, Kishore</au><au>Hall, James</au><au>Johnson, Leigh</au><au>O’Bryant, Sid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment</atitle><jtitle>Dementia and Geriatric Cognitive Disorders Extra</jtitle><addtitle>Dement Geriatr Cogn Disord Extra</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>10</volume><issue>3</issue><spage>154</spage><epage>162</epage><pages>154-162</pages><issn>1664-5464</issn><eissn>1664-5464</eissn><abstract>Objectives: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI). 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| subjects | Age Alzheimer's disease Between-subjects design Blood pressure Cardiovascular diseases cardiovascular risk factors Cholesterol Cognition & reasoning Cognition disorders Cognitive ability Dementia Demographics Diabetes Education Health aspects Hispanic Americans Hypertension Medical diagnosis Memory Metabolic disorders mexican american Mexican Americans mild cognitive impairment Neuropsychology Obesity Older people Psychological aspects Research Article Risk factors Statistics Triglycerides |
| title | Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment |
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