Effects of resistance training on muscle strength, insulin-like growth factor-1, and insulin-like growth factor–binding protein-3 in healthy elderly subjects: a systematic review and meta-analysis of randomized controlled trials
Background Findings regarding the effects of resistance training (RT) on muscle strength, serum level of IGF-1, and its binding proteins are contradictory. To resolve this contradiction, we performed a systematic review and meta-analysis to investigate the effects of RT on muscle strength, the level...
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| Veröffentlicht in: | Hormones (Athens, Greece) Greece), 2021-06, Vol.20 (2), p.247-257 |
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| creator | Amiri, Niloufar Fathei, Mehrdad Mosaferi Ziaaldini, Mohammad |
| description | Background
Findings regarding the effects of resistance training (RT) on muscle strength, serum level of IGF-1, and its binding proteins are contradictory. To resolve this contradiction, we performed a systematic review and meta-analysis to investigate the effects of RT on muscle strength, the levels of serum IGF-1, and IGF-binding protein-3 in the elderly and aged.
Materials and methods
The PubMed, CINAHL, Medline, Google Scholar, and Scopus databases and reference lists of included studies were systematically searched to identify randomized controlled trials (RCTs) comparing subjects who underwent RT and control individuals up to May 15, 2020. This study was performed following the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. We identified and analyzed 11 eligible trials in this meta-analysis.
Results
Pooled data displayed an overall significant elevation in IGF-1 (mean difference (MD): 17.34 ng/ml; 95% confidence interval (CI): 7.23, 27.46) and in muscle strength in leg press (SMD: 0.82; 95% CI: 0.30, 1.34) and bench press (SMD: 0.82; 95% CI: 0.42, 1.23) following RT. By contrast, the pooled estimate showed a non-significant elevation in IGFBP-3 (MD: 0.13 ng/ml; 95% CI: − 39.39, 39.65). Subgroup analysis revealed that the elevation in serum IGF-1 levels after RT was significant only in women (MD: 19.30 ng/ml); moreover, it increased after intervention durations of both > 12 weeks (MD: 21.98 ng/ml) and of ≤ 12 weeks (MD: 15.31 ng/ml).
Conclusion
RT was associated with elevated muscle strength. Moreover, RT was correlated with increased serum levels of IGF-1 among women and among those who received the training for ≤ 12 weeks or > 12 weeks. Further studies are required to elucidate the mechanisms underlying the impact of RT on IGF-1, IGFBP-3, and muscle strength. |
| doi_str_mv | 10.1007/s42000-020-00250-6 |
| format | Article |
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Findings regarding the effects of resistance training (RT) on muscle strength, serum level of IGF-1, and its binding proteins are contradictory. To resolve this contradiction, we performed a systematic review and meta-analysis to investigate the effects of RT on muscle strength, the levels of serum IGF-1, and IGF-binding protein-3 in the elderly and aged.
Materials and methods
The PubMed, CINAHL, Medline, Google Scholar, and Scopus databases and reference lists of included studies were systematically searched to identify randomized controlled trials (RCTs) comparing subjects who underwent RT and control individuals up to May 15, 2020. This study was performed following the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. We identified and analyzed 11 eligible trials in this meta-analysis.
Results
Pooled data displayed an overall significant elevation in IGF-1 (mean difference (MD): 17.34 ng/ml; 95% confidence interval (CI): 7.23, 27.46) and in muscle strength in leg press (SMD: 0.82; 95% CI: 0.30, 1.34) and bench press (SMD: 0.82; 95% CI: 0.42, 1.23) following RT. By contrast, the pooled estimate showed a non-significant elevation in IGFBP-3 (MD: 0.13 ng/ml; 95% CI: − 39.39, 39.65). Subgroup analysis revealed that the elevation in serum IGF-1 levels after RT was significant only in women (MD: 19.30 ng/ml); moreover, it increased after intervention durations of both > 12 weeks (MD: 21.98 ng/ml) and of ≤ 12 weeks (MD: 15.31 ng/ml).
Conclusion
RT was associated with elevated muscle strength. Moreover, RT was correlated with increased serum levels of IGF-1 among women and among those who received the training for ≤ 12 weeks or > 12 weeks. Further studies are required to elucidate the mechanisms underlying the impact of RT on IGF-1, IGFBP-3, and muscle strength.</description><identifier>ISSN: 1109-3099</identifier><identifier>EISSN: 2520-8721</identifier><identifier>DOI: 10.1007/s42000-020-00250-6</identifier><identifier>PMID: 33442864</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Endocrinology ; Female ; Humans ; Insulin-Like Growth Factor Binding Protein 3 ; Insulin-Like Growth Factor I - metabolism ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Muscle Strength ; Randomized Controlled Trials as Topic ; Resistance Training ; Review Article</subject><ispartof>Hormones (Athens, Greece), 2021-06, Vol.20 (2), p.247-257</ispartof><rights>Hellenic Endocrine Society 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-38b19f11683bc5747079dbf66f0eefaff9a11c6e4531de1541503cea03ed528c3</citedby><cites>FETCH-LOGICAL-c347t-38b19f11683bc5747079dbf66f0eefaff9a11c6e4531de1541503cea03ed528c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s42000-020-00250-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s42000-020-00250-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33442864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amiri, Niloufar</creatorcontrib><creatorcontrib>Fathei, Mehrdad</creatorcontrib><creatorcontrib>Mosaferi Ziaaldini, Mohammad</creatorcontrib><title>Effects of resistance training on muscle strength, insulin-like growth factor-1, and insulin-like growth factor–binding protein-3 in healthy elderly subjects: a systematic review and meta-analysis of randomized controlled trials</title><title>Hormones (Athens, Greece)</title><addtitle>Hormones</addtitle><addtitle>Hormones (Athens)</addtitle><description>Background
Findings regarding the effects of resistance training (RT) on muscle strength, serum level of IGF-1, and its binding proteins are contradictory. To resolve this contradiction, we performed a systematic review and meta-analysis to investigate the effects of RT on muscle strength, the levels of serum IGF-1, and IGF-binding protein-3 in the elderly and aged.
Materials and methods
The PubMed, CINAHL, Medline, Google Scholar, and Scopus databases and reference lists of included studies were systematically searched to identify randomized controlled trials (RCTs) comparing subjects who underwent RT and control individuals up to May 15, 2020. This study was performed following the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. We identified and analyzed 11 eligible trials in this meta-analysis.
Results
Pooled data displayed an overall significant elevation in IGF-1 (mean difference (MD): 17.34 ng/ml; 95% confidence interval (CI): 7.23, 27.46) and in muscle strength in leg press (SMD: 0.82; 95% CI: 0.30, 1.34) and bench press (SMD: 0.82; 95% CI: 0.42, 1.23) following RT. By contrast, the pooled estimate showed a non-significant elevation in IGFBP-3 (MD: 0.13 ng/ml; 95% CI: − 39.39, 39.65). Subgroup analysis revealed that the elevation in serum IGF-1 levels after RT was significant only in women (MD: 19.30 ng/ml); moreover, it increased after intervention durations of both > 12 weeks (MD: 21.98 ng/ml) and of ≤ 12 weeks (MD: 15.31 ng/ml).
Conclusion
RT was associated with elevated muscle strength. Moreover, RT was correlated with increased serum levels of IGF-1 among women and among those who received the training for ≤ 12 weeks or > 12 weeks. Further studies are required to elucidate the mechanisms underlying the impact of RT on IGF-1, IGFBP-3, and muscle strength.</description><subject>Aged</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor Binding Protein 3</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Muscle Strength</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Resistance Training</subject><subject>Review Article</subject><issn>1109-3099</issn><issn>2520-8721</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kbtuFDEUhkcIRJbAC1AglxQZ8G1udCgKFykSDdSWx3O868VjBx8P0VDxDrwhBc-BdzdQprCOL9_5_dt_VT1n9BWjtHuNklNKa8rLoLyhdfug2vCmLPuOs4fVhjE61IIOw1n1BHFPadsMPXtcnQkhJe9buan-XFkLJiOJliRAh1kHAyQn7YILWxIDmRc0HgjmBGGbdxfEBVy8C7V3X4FsU7zNO2K1yTHV7ILoMN1D_P75a3RhOkjfpJihQKLgZAfa591KwE-Q_EpwGfcHX2-IJrhihllnZ4rF7w5uj3fMkHWtg_ZrcX20X3bj7H7AREwMOUXvyzQnpz0-rR7ZUuDZXT2vvry7-nz5ob7-9P7j5dvr2gjZ5Vr0IxssY20vRtN0sqPdMI22bS0FsNraQTNmWpCNYBOwRrKGCgOaCpga3htxXr086ZbHfVsAs5odGvBeB4gLKi67noq2kbyg_ISaFBETWHWT3KzTqhhVh3zVKV9V8lXHfFVbml7c6S_jDNP_ln-BFkCcACxHYQtJ7eOSyi_hfbJ_AaMruAs</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Amiri, Niloufar</creator><creator>Fathei, Mehrdad</creator><creator>Mosaferi Ziaaldini, Mohammad</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210601</creationdate><title>Effects of resistance training on muscle strength, insulin-like growth factor-1, and insulin-like growth factor–binding protein-3 in healthy elderly subjects: a systematic review and meta-analysis of randomized controlled trials</title><author>Amiri, Niloufar ; Fathei, Mehrdad ; Mosaferi Ziaaldini, Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-38b19f11683bc5747079dbf66f0eefaff9a11c6e4531de1541503cea03ed528c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor Binding Protein 3</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Muscle Strength</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Resistance Training</topic><topic>Review Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amiri, Niloufar</creatorcontrib><creatorcontrib>Fathei, Mehrdad</creatorcontrib><creatorcontrib>Mosaferi Ziaaldini, Mohammad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormones (Athens, Greece)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amiri, Niloufar</au><au>Fathei, Mehrdad</au><au>Mosaferi Ziaaldini, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of resistance training on muscle strength, insulin-like growth factor-1, and insulin-like growth factor–binding protein-3 in healthy elderly subjects: a systematic review and meta-analysis of randomized controlled trials</atitle><jtitle>Hormones (Athens, Greece)</jtitle><stitle>Hormones</stitle><addtitle>Hormones (Athens)</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>20</volume><issue>2</issue><spage>247</spage><epage>257</epage><pages>247-257</pages><issn>1109-3099</issn><eissn>2520-8721</eissn><abstract>Background
Findings regarding the effects of resistance training (RT) on muscle strength, serum level of IGF-1, and its binding proteins are contradictory. To resolve this contradiction, we performed a systematic review and meta-analysis to investigate the effects of RT on muscle strength, the levels of serum IGF-1, and IGF-binding protein-3 in the elderly and aged.
Materials and methods
The PubMed, CINAHL, Medline, Google Scholar, and Scopus databases and reference lists of included studies were systematically searched to identify randomized controlled trials (RCTs) comparing subjects who underwent RT and control individuals up to May 15, 2020. This study was performed following the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. We identified and analyzed 11 eligible trials in this meta-analysis.
Results
Pooled data displayed an overall significant elevation in IGF-1 (mean difference (MD): 17.34 ng/ml; 95% confidence interval (CI): 7.23, 27.46) and in muscle strength in leg press (SMD: 0.82; 95% CI: 0.30, 1.34) and bench press (SMD: 0.82; 95% CI: 0.42, 1.23) following RT. By contrast, the pooled estimate showed a non-significant elevation in IGFBP-3 (MD: 0.13 ng/ml; 95% CI: − 39.39, 39.65). Subgroup analysis revealed that the elevation in serum IGF-1 levels after RT was significant only in women (MD: 19.30 ng/ml); moreover, it increased after intervention durations of both > 12 weeks (MD: 21.98 ng/ml) and of ≤ 12 weeks (MD: 15.31 ng/ml).
Conclusion
RT was associated with elevated muscle strength. Moreover, RT was correlated with increased serum levels of IGF-1 among women and among those who received the training for ≤ 12 weeks or > 12 weeks. Further studies are required to elucidate the mechanisms underlying the impact of RT on IGF-1, IGFBP-3, and muscle strength.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33442864</pmid><doi>10.1007/s42000-020-00250-6</doi><tpages>11</tpages></addata></record> |
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| subjects | Aged Endocrinology Female Humans Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor I - metabolism Medicine Medicine & Public Health Metabolic Diseases Muscle Strength Randomized Controlled Trials as Topic Resistance Training Review Article |
| title | Effects of resistance training on muscle strength, insulin-like growth factor-1, and insulin-like growth factor–binding protein-3 in healthy elderly subjects: a systematic review and meta-analysis of randomized controlled trials |
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