Magnetic resonance spectroscopy reveals mitochondrial dysfunction in amyotrophic lateral sclerosis

Mitochondrial dysfunction is postulated to be central to amyotrophic lateral sclerosis (ALS) pathophysiology. Evidence comes primarily from disease models and conclusive data to support bioenergetic dysfunction in vivo in patients is currently lacking. This study is the first to assess mitochondrial...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2020-12, Vol.143 (12), p.3603-3618
Hauptverfasser:	Sassani, Matilde, Alix, James J, McDermott, Christopher J, Baster, Kathleen, Hoggard, Nigel, Wild, Jim M, Mortiboys, Heather J, Shaw, Pamela J, Wilkinson, Iain D, Jenkins, Thomas M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Aged Amyotrophic Lateral Sclerosis - metabolism Brain Chemistry Cross-Sectional Studies Energy Metabolism Female Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged Mitochondria - chemistry Mitochondrial Diseases - metabolism Motor Neurons - metabolism Motor Neurons - pathology Muscle Contraction Muscle Strength Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Oxidative Phosphorylation Phosphocreatine - metabolism Walking
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