Clinical features associated with drooling in Parkinson’s disease
Introduction Drooling is characterized by an excessive pooling of saliva in the oral cavity. The exact pathophysiological mechanism of drooling in Parkinson’s disease (PD) is not yet fully understood. Objective To identify the relationship between drooling and other clinical features in people diagn...
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| Veröffentlicht in: | Neurological sciences 2021-03, Vol.42 (3), p.895-903 |
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| creator | Nascimento, David |
| description | Introduction
Drooling is characterized by an excessive pooling of saliva in the oral cavity. The exact pathophysiological mechanism of drooling in Parkinson’s disease (PD) is not yet fully understood.
Objective
To identify the relationship between drooling and other clinical features in people diagnosed with PD.
Method
Research on the topic was carried out on the PubMed and ScienceDirect electronic databases. Articles published between March 2015 and March 2020 were selected. Search terms and inclusion and exclusion criteria were previously defined. The articles included met those requirements.
Results
Sixteen articles were included for analysis. The prevalence of drooling varies between 9.26 and 70% and can occur at any stage of the disease. Higher prevalence of drooling is related to disease duration, disease severity, older age, male, levodopa equivalent dose, hypomimia, dysphagia, dysarthria, cognition, sleep, non-dominant tremor, motor fluctuations, bradykinesia, more symmetric pattern, gastrointestinal and urinary problems, sexual dysfunction, obstipation, and orthostatic hypotension. However, it is not related to hallucinations, rapid eye movement sleep behavior disorder, akinetic-rigid PD, mixed, nor dyskinesias.
Conclusion
Drooling is not caused by a single factor; it is influenced and related to several clinical features. Some clinical factors participate in the onset of drooling while others are concomitant. |
| doi_str_mv | 10.1007/s10072-020-05005-0 |
| format | Article |
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Drooling is characterized by an excessive pooling of saliva in the oral cavity. The exact pathophysiological mechanism of drooling in Parkinson’s disease (PD) is not yet fully understood.
Objective
To identify the relationship between drooling and other clinical features in people diagnosed with PD.
Method
Research on the topic was carried out on the PubMed and ScienceDirect electronic databases. Articles published between March 2015 and March 2020 were selected. Search terms and inclusion and exclusion criteria were previously defined. The articles included met those requirements.
Results
Sixteen articles were included for analysis. The prevalence of drooling varies between 9.26 and 70% and can occur at any stage of the disease. Higher prevalence of drooling is related to disease duration, disease severity, older age, male, levodopa equivalent dose, hypomimia, dysphagia, dysarthria, cognition, sleep, non-dominant tremor, motor fluctuations, bradykinesia, more symmetric pattern, gastrointestinal and urinary problems, sexual dysfunction, obstipation, and orthostatic hypotension. However, it is not related to hallucinations, rapid eye movement sleep behavior disorder, akinetic-rigid PD, mixed, nor dyskinesias.
Conclusion
Drooling is not caused by a single factor; it is influenced and related to several clinical features. Some clinical factors participate in the onset of drooling while others are concomitant.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-020-05005-0</identifier><identifier>PMID: 33443673</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Cognition ; Dysphagia ; Hallucinations ; Humans ; Hypokinesia ; Hypotension ; Levodopa ; Male ; Medicine ; Medicine & Public Health ; Movement disorders ; Neurodegenerative diseases ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Oral cavity ; Parkinson Disease - complications ; Parkinson Disease - epidemiology ; Parkinson's disease ; Psychiatry ; REM sleep ; REM Sleep Behavior Disorder ; Review Article ; Saliva ; Sialorrhea - epidemiology ; Sialorrhea - etiology ; Sleep disorders ; Tremor</subject><ispartof>Neurological sciences, 2021-03, Vol.42 (3), p.895-903</ispartof><rights>Fondazione Società Italiana di Neurologia 2021</rights><rights>Fondazione Società Italiana di Neurologia 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-70221bc0b5b5478fa95c8b6955263c42e91198c0002201a7fe7ef0239e85c5203</citedby><cites>FETCH-LOGICAL-c375t-70221bc0b5b5478fa95c8b6955263c42e91198c0002201a7fe7ef0239e85c5203</cites><orcidid>0000-0002-6931-4660</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10072-020-05005-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10072-020-05005-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33443673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nascimento, David</creatorcontrib><title>Clinical features associated with drooling in Parkinson’s disease</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>Introduction
Drooling is characterized by an excessive pooling of saliva in the oral cavity. The exact pathophysiological mechanism of drooling in Parkinson’s disease (PD) is not yet fully understood.
Objective
To identify the relationship between drooling and other clinical features in people diagnosed with PD.
Method
Research on the topic was carried out on the PubMed and ScienceDirect electronic databases. Articles published between March 2015 and March 2020 were selected. Search terms and inclusion and exclusion criteria were previously defined. The articles included met those requirements.
Results
Sixteen articles were included for analysis. The prevalence of drooling varies between 9.26 and 70% and can occur at any stage of the disease. Higher prevalence of drooling is related to disease duration, disease severity, older age, male, levodopa equivalent dose, hypomimia, dysphagia, dysarthria, cognition, sleep, non-dominant tremor, motor fluctuations, bradykinesia, more symmetric pattern, gastrointestinal and urinary problems, sexual dysfunction, obstipation, and orthostatic hypotension. However, it is not related to hallucinations, rapid eye movement sleep behavior disorder, akinetic-rigid PD, mixed, nor dyskinesias.
Conclusion
Drooling is not caused by a single factor; it is influenced and related to several clinical features. Some clinical factors participate in the onset of drooling while others are concomitant.</description><subject>Aged</subject><subject>Cognition</subject><subject>Dysphagia</subject><subject>Hallucinations</subject><subject>Humans</subject><subject>Hypokinesia</subject><subject>Hypotension</subject><subject>Levodopa</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Oral cavity</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson's disease</subject><subject>Psychiatry</subject><subject>REM sleep</subject><subject>REM Sleep Behavior Disorder</subject><subject>Review Article</subject><subject>Saliva</subject><subject>Sialorrhea - epidemiology</subject><subject>Sialorrhea - etiology</subject><subject>Sleep disorders</subject><subject>Tremor</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kL1OwzAURi0EoqXwAgwoEgtL4NqO42REFX9SJRhgthzHKS5pUnwTITZeg9fjSXBJAYmBxbbk4-9-PoQcUjilAPIM1yuLgUEMAkDEsEXGVOQQ80Rm25szzWQyInuICwCgCeW7ZMR5kvBU8jGZTmvXOKPrqLK6673FSCO2xunOltGL6x6j0rdtgOaRa6I77Z9cg23z8faOUenQarT7ZKfSNdqDzT4hD5cX99PreHZ7dTM9n8WGS9HFEhijhYFCFCL0q3QuTFakuRAs5SZhNqc0z0xoyRhQLSsrbQWM5zYTRjDgE3Iy5K58-9xb7NTSobF1rRvb9qhYSAUePp0G9PgPumh734R2gcokTTlnWaDYQBnfInpbqZV3S-1fFQW1lqsGxSooVl-K1brF0Sa6L5a2_Hny7TQAfAAwXDVz639n_xP7CREShSY</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Nascimento, David</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6931-4660</orcidid></search><sort><creationdate>20210301</creationdate><title>Clinical features associated with drooling in Parkinson’s disease</title><author>Nascimento, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-70221bc0b5b5478fa95c8b6955263c42e91198c0002201a7fe7ef0239e85c5203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Cognition</topic><topic>Dysphagia</topic><topic>Hallucinations</topic><topic>Humans</topic><topic>Hypokinesia</topic><topic>Hypotension</topic><topic>Levodopa</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Oral cavity</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson's disease</topic><topic>Psychiatry</topic><topic>REM sleep</topic><topic>REM Sleep Behavior Disorder</topic><topic>Review Article</topic><topic>Saliva</topic><topic>Sialorrhea - epidemiology</topic><topic>Sialorrhea - etiology</topic><topic>Sleep disorders</topic><topic>Tremor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nascimento, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nascimento, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical features associated with drooling in Parkinson’s disease</atitle><jtitle>Neurological sciences</jtitle><stitle>Neurol Sci</stitle><addtitle>Neurol Sci</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>42</volume><issue>3</issue><spage>895</spage><epage>903</epage><pages>895-903</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><abstract>Introduction
Drooling is characterized by an excessive pooling of saliva in the oral cavity. The exact pathophysiological mechanism of drooling in Parkinson’s disease (PD) is not yet fully understood.
Objective
To identify the relationship between drooling and other clinical features in people diagnosed with PD.
Method
Research on the topic was carried out on the PubMed and ScienceDirect electronic databases. Articles published between March 2015 and March 2020 were selected. Search terms and inclusion and exclusion criteria were previously defined. The articles included met those requirements.
Results
Sixteen articles were included for analysis. The prevalence of drooling varies between 9.26 and 70% and can occur at any stage of the disease. Higher prevalence of drooling is related to disease duration, disease severity, older age, male, levodopa equivalent dose, hypomimia, dysphagia, dysarthria, cognition, sleep, non-dominant tremor, motor fluctuations, bradykinesia, more symmetric pattern, gastrointestinal and urinary problems, sexual dysfunction, obstipation, and orthostatic hypotension. However, it is not related to hallucinations, rapid eye movement sleep behavior disorder, akinetic-rigid PD, mixed, nor dyskinesias.
Conclusion
Drooling is not caused by a single factor; it is influenced and related to several clinical features. Some clinical factors participate in the onset of drooling while others are concomitant.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33443673</pmid><doi>10.1007/s10072-020-05005-0</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6931-4660</orcidid></addata></record> |
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| ispartof | Neurological sciences, 2021-03, Vol.42 (3), p.895-903 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Cognition Dysphagia Hallucinations Humans Hypokinesia Hypotension Levodopa Male Medicine Medicine & Public Health Movement disorders Neurodegenerative diseases Neurology Neuroradiology Neurosciences Neurosurgery Oral cavity Parkinson Disease - complications Parkinson Disease - epidemiology Parkinson's disease Psychiatry REM sleep REM Sleep Behavior Disorder Review Article Saliva Sialorrhea - epidemiology Sialorrhea - etiology Sleep disorders Tremor |
| title | Clinical features associated with drooling in Parkinson’s disease |
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