Liver Fat Quantification by Ultrasound in Children: A Prospective Study

Liver Fat Quantification by Ultrasound in Children: A Prospective Study

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children in certain regions and is rising in prevalence with increasing obesity. Accurate noninvasive imaging methods for diagnosing and quantifying liver fat are needed to guide NAFLD management. To evalua...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of roentgenology (1976) 2021-10, Vol.217 (4), p.996-1006
Hauptverfasser: D'Hondt, Aurélie, Rubesova, Erika, Xie, Hua, Shamdasani, Vijay, Barth, Richard A
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1006
container_issue 4
container_start_page 996
container_title American journal of roentgenology (1976)
container_volume 217
creator D'Hondt, Aurélie
Rubesova, Erika
Xie, Hua
Shamdasani, Vijay
Barth, Richard A
description Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children in certain regions and is rising in prevalence with increasing obesity. Accurate noninvasive imaging methods for diagnosing and quantifying liver fat are needed to guide NAFLD management. To evaluate four ultrasound technologies for quantitative assessment of liver fat content in children, using MRI proton density fat fraction (PDFF) as reference standard. This prospective study enrolled children who underwent clinical abdominal MRI without general anesthesia between November 2018 and July 2019. Patients underwent investigational liver ultrasound within a day of 1.5 or 3T MRI. Acquired ultrasound radiofrequency data were processed offline to compute acoustic attenuation coefficient, hepatorenal index (HRI), Nakagami parameter, and shear wave elastography (SWE) parameters (elasticity, viscosity and dispersion). Ultrasound parameters were compared to MRI PDFF obtained using a multi-echo sequence. A second observer independently performed offline attenuation coefficient and HRI measurements in all patients. A total of 48 patients were enrolled: 22 girls, 26 boys; mean age 13 years (range, 7-17 years); mean body mass index 22.25 kg/m2 (range, 14.5-48.1 kg/m2). A total of 21% (10/48) had steatosis (PDFF >5%). PDFF was correlated with attenuation coefficient (r=0.76, 95% CI 0.60-0.86, p
doi_str_mv 10.2214/AJR.20.24874
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2477515234</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2477515234</sourcerecordid><originalsourceid>FETCH-LOGICAL-c291t-ffe99cff45c57fccebe95f6502c266dda3951c6e3557bc5190a4e4dca53d86903</originalsourceid><addsrcrecordid>eNo9kDtPwzAURi0EoqWwMSOPDKT4GcdsVdUWUCWeldgixw9hlCbFdpD670nVwnS_4dxP9x4ALjEaE4LZ7eTxdUz6zArBjsAQc5ZnFDN8DIaI5jgrEP0YgLMYvxBCopDiFAwoZbRgXAzBYul_bIBzleBLp5rkndcq-baB1Rau6hRUbLvGQN_A6aevTbDNHZzA59DGjdWpX4ZvqTPbc3DiVB3txWGOwGo-e5_eZ8unxcN0ssw0kThlzlkptXOMay6c1raykrucI6JJnhujqORY55ZyLirNsUSKWWa04tQUuUR0BK73vZvQfnc2pnLto7Z1rRrbdrEkTAiOOekfHIGbPar7Y2OwrtwEv1ZhW2JU7tSVvbqS9HmnrsevDs1dtbbmH_5zRX8BicJpPw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2477515234</pqid></control><display><type>article</type><title>Liver Fat Quantification by Ultrasound in Children: A Prospective Study</title><source>American Roentgen Ray Society</source><source>Alma/SFX Local Collection</source><creator>D'Hondt, Aurélie ; Rubesova, Erika ; Xie, Hua ; Shamdasani, Vijay ; Barth, Richard A</creator><creatorcontrib>D'Hondt, Aurélie ; Rubesova, Erika ; Xie, Hua ; Shamdasani, Vijay ; Barth, Richard A</creatorcontrib><description>Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children in certain regions and is rising in prevalence with increasing obesity. Accurate noninvasive imaging methods for diagnosing and quantifying liver fat are needed to guide NAFLD management. To evaluate four ultrasound technologies for quantitative assessment of liver fat content in children, using MRI proton density fat fraction (PDFF) as reference standard. This prospective study enrolled children who underwent clinical abdominal MRI without general anesthesia between November 2018 and July 2019. Patients underwent investigational liver ultrasound within a day of 1.5 or 3T MRI. Acquired ultrasound radiofrequency data were processed offline to compute acoustic attenuation coefficient, hepatorenal index (HRI), Nakagami parameter, and shear wave elastography (SWE) parameters (elasticity, viscosity and dispersion). Ultrasound parameters were compared to MRI PDFF obtained using a multi-echo sequence. A second observer independently performed offline attenuation coefficient and HRI measurements in all patients. A total of 48 patients were enrolled: 22 girls, 26 boys; mean age 13 years (range, 7-17 years); mean body mass index 22.25 kg/m2 (range, 14.5-48.1 kg/m2). A total of 21% (10/48) had steatosis (PDFF &gt;5%). PDFF was correlated with attenuation coefficient (r=0.76, 95% CI 0.60-0.86, p&lt;.001), HRI (r=0.84, 95% CI 0.74-0.91, p&lt;.001), and Nakagami parameter (r=0.55, 95% CI, 0.32-0.72, p&lt;.001), but not SWE parameters (r=0.05-0.25; p&gt;.05). In patients with no, mild, moderate, and severe steatosis based on PDFF, mean±SD attenuation coefficient was 0.48±0.08, 0.54±0.03, 0.57±0.04, and 0.86±0.07 dB/cm/MHz, and mean±SD HRI was 1.28±0.30, 1.59±0.23, 2.25±0.04, and 3.06±0.49. For attenuation coefficient, threshold of 0.54 dB/cm/MHz achieved sensitivity 80% and specificity 82% for steatosis, and of 0.60 dB/cm/MHz achieved sensitivity 80% and specificity 98% for moderate steatosis. For HRI, threshold of 1.48 achieved sensitivity 90% and specificity 76% for steatosis, and of 2.11 achieved sensitivity 100% and specificity 100% for moderate steatosis. Inter-observer concordance coefficient was 0.92 for attenuation coefficient and 0.91 for HRI. Attenuation coefficient and HRI accurately detected and quantified liver fat in this small sample of children. Quantitative ultrasound parameters may guide NAFLD diagnosis and management in children.</description><identifier>ISSN: 0361-803X</identifier><identifier>EISSN: 1546-3141</identifier><identifier>DOI: 10.2214/AJR.20.24874</identifier><identifier>PMID: 33438457</identifier><language>eng</language><publisher>United States</publisher><ispartof>American journal of roentgenology (1976), 2021-10, Vol.217 (4), p.996-1006</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c291t-ffe99cff45c57fccebe95f6502c266dda3951c6e3557bc5190a4e4dca53d86903</citedby><cites>FETCH-LOGICAL-c291t-ffe99cff45c57fccebe95f6502c266dda3951c6e3557bc5190a4e4dca53d86903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4106,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33438457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D'Hondt, Aurélie</creatorcontrib><creatorcontrib>Rubesova, Erika</creatorcontrib><creatorcontrib>Xie, Hua</creatorcontrib><creatorcontrib>Shamdasani, Vijay</creatorcontrib><creatorcontrib>Barth, Richard A</creatorcontrib><title>Liver Fat Quantification by Ultrasound in Children: A Prospective Study</title><title>American journal of roentgenology (1976)</title><addtitle>AJR Am J Roentgenol</addtitle><description>Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children in certain regions and is rising in prevalence with increasing obesity. Accurate noninvasive imaging methods for diagnosing and quantifying liver fat are needed to guide NAFLD management. To evaluate four ultrasound technologies for quantitative assessment of liver fat content in children, using MRI proton density fat fraction (PDFF) as reference standard. This prospective study enrolled children who underwent clinical abdominal MRI without general anesthesia between November 2018 and July 2019. Patients underwent investigational liver ultrasound within a day of 1.5 or 3T MRI. Acquired ultrasound radiofrequency data were processed offline to compute acoustic attenuation coefficient, hepatorenal index (HRI), Nakagami parameter, and shear wave elastography (SWE) parameters (elasticity, viscosity and dispersion). Ultrasound parameters were compared to MRI PDFF obtained using a multi-echo sequence. A second observer independently performed offline attenuation coefficient and HRI measurements in all patients. A total of 48 patients were enrolled: 22 girls, 26 boys; mean age 13 years (range, 7-17 years); mean body mass index 22.25 kg/m2 (range, 14.5-48.1 kg/m2). A total of 21% (10/48) had steatosis (PDFF &gt;5%). PDFF was correlated with attenuation coefficient (r=0.76, 95% CI 0.60-0.86, p&lt;.001), HRI (r=0.84, 95% CI 0.74-0.91, p&lt;.001), and Nakagami parameter (r=0.55, 95% CI, 0.32-0.72, p&lt;.001), but not SWE parameters (r=0.05-0.25; p&gt;.05). In patients with no, mild, moderate, and severe steatosis based on PDFF, mean±SD attenuation coefficient was 0.48±0.08, 0.54±0.03, 0.57±0.04, and 0.86±0.07 dB/cm/MHz, and mean±SD HRI was 1.28±0.30, 1.59±0.23, 2.25±0.04, and 3.06±0.49. For attenuation coefficient, threshold of 0.54 dB/cm/MHz achieved sensitivity 80% and specificity 82% for steatosis, and of 0.60 dB/cm/MHz achieved sensitivity 80% and specificity 98% for moderate steatosis. For HRI, threshold of 1.48 achieved sensitivity 90% and specificity 76% for steatosis, and of 2.11 achieved sensitivity 100% and specificity 100% for moderate steatosis. Inter-observer concordance coefficient was 0.92 for attenuation coefficient and 0.91 for HRI. Attenuation coefficient and HRI accurately detected and quantified liver fat in this small sample of children. Quantitative ultrasound parameters may guide NAFLD diagnosis and management in children.</description><issn>0361-803X</issn><issn>1546-3141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNo9kDtPwzAURi0EoqWwMSOPDKT4GcdsVdUWUCWeldgixw9hlCbFdpD670nVwnS_4dxP9x4ALjEaE4LZ7eTxdUz6zArBjsAQc5ZnFDN8DIaI5jgrEP0YgLMYvxBCopDiFAwoZbRgXAzBYul_bIBzleBLp5rkndcq-baB1Rau6hRUbLvGQN_A6aevTbDNHZzA59DGjdWpX4ZvqTPbc3DiVB3txWGOwGo-e5_eZ8unxcN0ssw0kThlzlkptXOMay6c1raykrucI6JJnhujqORY55ZyLirNsUSKWWa04tQUuUR0BK73vZvQfnc2pnLto7Z1rRrbdrEkTAiOOekfHIGbPar7Y2OwrtwEv1ZhW2JU7tSVvbqS9HmnrsevDs1dtbbmH_5zRX8BicJpPw</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>D'Hondt, Aurélie</creator><creator>Rubesova, Erika</creator><creator>Xie, Hua</creator><creator>Shamdasani, Vijay</creator><creator>Barth, Richard A</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20211001</creationdate><title>Liver Fat Quantification by Ultrasound in Children: A Prospective Study</title><author>D'Hondt, Aurélie ; Rubesova, Erika ; Xie, Hua ; Shamdasani, Vijay ; Barth, Richard A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c291t-ffe99cff45c57fccebe95f6502c266dda3951c6e3557bc5190a4e4dca53d86903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D'Hondt, Aurélie</creatorcontrib><creatorcontrib>Rubesova, Erika</creatorcontrib><creatorcontrib>Xie, Hua</creatorcontrib><creatorcontrib>Shamdasani, Vijay</creatorcontrib><creatorcontrib>Barth, Richard A</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of roentgenology (1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D'Hondt, Aurélie</au><au>Rubesova, Erika</au><au>Xie, Hua</au><au>Shamdasani, Vijay</au><au>Barth, Richard A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liver Fat Quantification by Ultrasound in Children: A Prospective Study</atitle><jtitle>American journal of roentgenology (1976)</jtitle><addtitle>AJR Am J Roentgenol</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>217</volume><issue>4</issue><spage>996</spage><epage>1006</epage><pages>996-1006</pages><issn>0361-803X</issn><eissn>1546-3141</eissn><abstract>Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children in certain regions and is rising in prevalence with increasing obesity. Accurate noninvasive imaging methods for diagnosing and quantifying liver fat are needed to guide NAFLD management. To evaluate four ultrasound technologies for quantitative assessment of liver fat content in children, using MRI proton density fat fraction (PDFF) as reference standard. This prospective study enrolled children who underwent clinical abdominal MRI without general anesthesia between November 2018 and July 2019. Patients underwent investigational liver ultrasound within a day of 1.5 or 3T MRI. Acquired ultrasound radiofrequency data were processed offline to compute acoustic attenuation coefficient, hepatorenal index (HRI), Nakagami parameter, and shear wave elastography (SWE) parameters (elasticity, viscosity and dispersion). Ultrasound parameters were compared to MRI PDFF obtained using a multi-echo sequence. A second observer independently performed offline attenuation coefficient and HRI measurements in all patients. A total of 48 patients were enrolled: 22 girls, 26 boys; mean age 13 years (range, 7-17 years); mean body mass index 22.25 kg/m2 (range, 14.5-48.1 kg/m2). A total of 21% (10/48) had steatosis (PDFF &gt;5%). PDFF was correlated with attenuation coefficient (r=0.76, 95% CI 0.60-0.86, p&lt;.001), HRI (r=0.84, 95% CI 0.74-0.91, p&lt;.001), and Nakagami parameter (r=0.55, 95% CI, 0.32-0.72, p&lt;.001), but not SWE parameters (r=0.05-0.25; p&gt;.05). In patients with no, mild, moderate, and severe steatosis based on PDFF, mean±SD attenuation coefficient was 0.48±0.08, 0.54±0.03, 0.57±0.04, and 0.86±0.07 dB/cm/MHz, and mean±SD HRI was 1.28±0.30, 1.59±0.23, 2.25±0.04, and 3.06±0.49. For attenuation coefficient, threshold of 0.54 dB/cm/MHz achieved sensitivity 80% and specificity 82% for steatosis, and of 0.60 dB/cm/MHz achieved sensitivity 80% and specificity 98% for moderate steatosis. For HRI, threshold of 1.48 achieved sensitivity 90% and specificity 76% for steatosis, and of 2.11 achieved sensitivity 100% and specificity 100% for moderate steatosis. Inter-observer concordance coefficient was 0.92 for attenuation coefficient and 0.91 for HRI. Attenuation coefficient and HRI accurately detected and quantified liver fat in this small sample of children. Quantitative ultrasound parameters may guide NAFLD diagnosis and management in children.</abstract><cop>United States</cop><pmid>33438457</pmid><doi>10.2214/AJR.20.24874</doi><tpages>11</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0361-803X
ispartof American journal of roentgenology (1976), 2021-10, Vol.217 (4), p.996-1006
issn 0361-803X
1546-3141
language eng
recordid cdi_proquest_miscellaneous_2477515234
source American Roentgen Ray Society; Alma/SFX Local Collection
title Liver Fat Quantification by Ultrasound in Children: A Prospective Study
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T20%3A54%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Liver%20Fat%20Quantification%20by%20Ultrasound%20in%20Children:%20A%20Prospective%20Study&rft.jtitle=American%20journal%20of%20roentgenology%20(1976)&rft.au=D'Hondt,%20Aur%C3%A9lie&rft.date=2021-10-01&rft.volume=217&rft.issue=4&rft.spage=996&rft.epage=1006&rft.pages=996-1006&rft.issn=0361-803X&rft.eissn=1546-3141&rft_id=info:doi/10.2214/AJR.20.24874&rft_dat=%3Cproquest_cross%3E2477515234%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2477515234&rft_id=info:pmid/33438457&rfr_iscdi=true