Engineered Phage Endolysin Eliminates Gardnerella Biofilm without Damaging Beneficial Bacteria in Bacterial Vaginosis Ex Vivo

Bacterial vaginosis is characterized by an imbalance of the vaginal microbiome and a characteristic biofilm formed on the vaginal epithelium, which is initiated and dominated by Gardnerella bacteria, and is frequently refractory to antibiotic treatment. We investigated endolysins of the type 1,4-bet...

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Veröffentlicht in:	Pathogens (Basel) 2021-01, Vol.10 (1), p.54, Article 54
Hauptverfasser:	Landlinger, Christine, Tisakova, Lenka, Oberbauer, Vera, Schwebs, Timo, Muhammad, Abbas, Latka, Agnieszka, Van Simaey, Leen, Vaneechoutte, Mario, Guschin, Alexander, Resch, Gregory, Swidsinski, Sonja, Swidsinski, Alexander, Corsini, Lorenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	antimicrobial resistance bacterial vaginosis endolysin Gardnerella biofilm genus-specificity Life Sciences & Biomedicine Microbiology prophage Science & Technology
Online-Zugang:	Volltext
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