IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor

CD8 + T cell exhaustion dampens antitumor immunity. Although several transcription factors have been identified that regulate T cell exhaustion, the molecular mechanisms by which CD8 + T cells are triggered to enter an exhausted state remain unclear. Here, we show that interleukin-2 (IL-2) acts as a...

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Veröffentlicht in:	Nature immunology 2021-03, Vol.22 (3), p.358-369
Hauptverfasser:	Liu, Yuying, Zhou, Nannan, Zhou, Li, Wang, Jing, Zhou, Yabo, Zhang, Tianzhen, Fang, Yi, Deng, Jinwei, Gao, Yunfeng, Liang, Xiaoyu, Lv, Jiadi, Wang, Zhenfeng, Xie, Jing, Xue, Yuanbo, Zhang, Huafeng, Ma, Jingwei, Tang, Ke, Fang, Yiliang, Cheng, Feiran, Zhang, Chengjuan, Dong, Bing, Zhao, Yuzhou, Yuan, Peng, Gao, Quanli, Zhang, Haizeng, Xiao-Feng Qin, F., Huang, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxytryptophan - metabolism 631/250/1619/554/1834/1269 631/250/580 Animal models Animals Antibodies, Neutralizing - pharmacology Antineoplastic Agents - pharmacology Antitumor activity Basic Helix-Loop-Helix Transcription Factors - deficiency Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biomedical and Life Sciences Biomedicine CD8 antigen CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Gene Expression Regulation, Neoplastic HCT116 Cells HEK293 Cells Humans Immunology Infectious Diseases Interleukin 2 Interleukin-2 - antagonists & inhibitors Interleukin-2 - genetics Interleukin-2 - metabolism Jurkat Cells Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - drug effects Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism MCF-7 Cells Melanoma, Experimental - drug therapy Melanoma, Experimental - immunology Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Microenvironments Molecular modelling Neoplasms - drug therapy Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology NIH 3T3 Cells Nuclear transport Receptors, Aryl Hydrocarbon - deficiency Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Signal Transduction Stat5 protein Transcription factors Translocation Tryptophan Tryptophan hydroxylase Tryptophan Hydroxylase - metabolism Tumor Microenvironment Tumors Xenograft Model Antitumor Assays
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