MicroRNA-199-3p up-regulation enhances chondrocyte proliferation and inhibits apoptosis in knee osteoarthritis via DNMT3A repression

Aim Studies have pivoted on the position of microRNAs (miRNAs) in knee osteoarthritis (KOA) but not the more specific function of miR-199-3p. Thus, this study is to uncover the mechanism of miR-199-3p in KOA. Methods Rats KOA models were established by modified Hulth method. miR-199-3p expression wa...

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Veröffentlicht in:	Inflammation research 2021-02, Vol.70 (2), p.171-182
Hauptverfasser:	Gu, Wenqi, Shi, Zhongmin, Song, Guoxun, Zhang, Hongtao
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Allergology Animal models Animals Apoptosis Arthritis Binding sites Bioinformatics Biomedical and Life Sciences Biomedical materials Biomedicine Cartilage Cartilage - metabolism Cartilage - pathology Cartilage diseases Cell Proliferation Cells, Cultured Chondrocytes Cytokines - blood Cytokines - genetics Deoxyribonucleic acid Dermatology DNA DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA methyltransferase DNA Methyltransferase 3A Down-Regulation Female Immunology Inflammation Inflammatory response Inhibitors Knee Knee Joint - metabolism Knee Joint - pathology Male MicroRNAs miRNA mRNA Neurology Original Research Paper Osteoarthritis Osteoarthritis, Knee - blood Osteoarthritis, Knee - genetics Osteoarthritis, Knee - metabolism Osteoarthritis, Knee - pathology Pharmacology/Toxicology Rats Rats, Sprague-Dawley Reporter gene Rheumatology RNA, Messenger - blood siRNA Up-Regulation
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